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Pathophysiological Role of Vascular Smooth Muscle Alkaline Phosphatase in Medial Artery Calcification

Journal of bone and mineral research, 2015-05, Vol.30 (5), p.824-836

2015

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Mechanism of Action and Structure-Activity Relationships of Tetracyclic Small Molecules Acting as Universal Positive Allosteric Modulators of the Cholecystokinin Receptor

Membranes (Basel), 2023-01, Vol.13 (2), p.150

2023

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Screening for positive allosteric modulators of cholecystokinin type 1 receptor potentially useful for management of obesity

SLAS discovery, 2022-10, Vol.27 (7), p.384-394

2022

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Ebselen inhibits QSOX1 enzymatic activity and suppresses invasion of pancreatic and renal cancer cell lines

Oncotarget, 2015-07, Vol.6 (21), p.18418-18428

2015

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Discovery of a Positive Allosteric Modulator of Cholecystokinin Action at CCK1R in Normal and Elevated Cholesterol

Frontiers in endocrinology (Lausanne), 2021-12, Vol.12, p.789957

2021

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Structure-activity relationships of thiadiazole agonists of the human secretin receptor

SLAS discovery, 2024-09, Vol.29 (6), p.100176-100176, Article 100176

2024

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TR-FRET-based high-throughput screening assay for identification of UBC13 inhibitors

Journal of biomolecular screening, 2012-02, Vol.17 (2), p.163-176

2012

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Discovery of small molecule positive allosteric modulators of the secretin receptor

Biochemical pharmacology, 2021-03, Vol.185, p.114451-114451, Article 114451

2021

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Engineering a leucine zipper-TRAIL homotrimer with improved cytotoxicity in tumor cells

Molecular cancer therapeutics, 2009-06, Vol.8 (6), p.1515-1525

2009

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High-throughput screening of tissue-nonspecific alkaline phosphatase for identification of effectors with diverse modes of action

Nature protocols, 2010-08, Vol.5 (8), p.1431-1439

2010

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Time-Resolved Fluorescence Assays

Methods in molecular biology (Clifton, N.J.), 2016-01, Vol.1439, p.131

2016

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Discovery and Validation of a Series of Aryl Sulfonamides as Selective Inhibitors of Tissue-Nonspecific Alkaline Phosphatase (TNAP)

Journal of medicinal chemistry, 2009-11, Vol.52 (21), p.6919-6925

2009

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Development of a Testing Funnel for Identification of Small-Molecule Modulators Targeting Secretin Receptors

SLAS discovery, 2021-01, Vol.26 (1), p.1-16

2021

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High-throughput screening for protein tyrosine phosphatase activity modulators

Methods in molecular biology (Clifton, N.J.), 2013, Vol.1053, p.223

2013

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Catalytic Acid−Base Groups in Yeast Pyruvate Decarboxylase. 2. Insights into the Specific Roles of D28 and E477 from the Rates and Stereospecificity of Formation of Carboligase Side Products

Biochemistry (Easton), 2001-06, Vol.40 (25), p.7369-7381

2001

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Structural and Kinetic Analysis of Catalysis by a Thiamin Diphosphate-Dependent Enzyme, Benzoylformate Decarboxylase

Biochemistry (Easton), 2003-02, Vol.42 (7), p.1820-1830

2003

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New Model for Activation of Yeast Pyruvate Decarboxylase by Substrate Consistent with the Alternating Sites Mechanism: Demonstration of the Existence of Two Active Forms of the Enzyme

Biochemistry (Easton), 2002-03, Vol.41 (12), p.3952-3967

2002

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Catalytic Acid−Base Groups in Yeast Pyruvate Decarboxylase. 1. Site-Directed Mutagenesis and Steady-State Kinetic Studies on the Enzyme with the D28A, H114F, H115F, and E477Q Substitutions

Biochemistry (Easton), 2001-06, Vol.40 (25), p.7355-7368

2001

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Phosphatase high-throughput screening assay design and selection

Methods in molecular biology (Clifton, N.J.), 2013, Vol.1053, p.7

Sergienko, Eduard A

2013

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Catalytic Acid−Base Groups in Yeast Pyruvate Decarboxylase. 3. A Steady-State Kinetic Model Consistent with the Behavior of both Wild-Type and Variant Enzymes at All Relevant pH Values

Biochemistry (Easton), 2001-06, Vol.40 (25), p.7382-7403

2001

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Spectroscopic Detection of Transient Thiamin Diphosphate-Bound Intermediates on Benzoylformate Decarboxylase

Biochemistry (Easton), 2000-11, Vol.39 (45), p.13862-13869

2000

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Yeast Pyruvate Decarboxylase Tetramers Can Dissociate into Dimers along Two Interfaces. Hybrids of Low-Activity D28A (or D28N) and E477Q Variants, with Substitution of Adjacent Active Center Acidic Groups from Different Subunits, Display Restored Activity

Biochemistry (Easton), 2002-05, Vol.41 (19), p.6164-6169

2002

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A method for direct assessment of tissue-nonspecific alkaline phosphatase (TNAP) inhibitors in blood samples

Methods in molecular biology (Clifton, N.J.), 2013, Vol.1053, p.103

2013

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Modulators of intestinal alkaline phosphatase

Methods in molecular biology (Clifton, N.J.), 2013, Vol.1053, p.135

2013

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New activity assays for ENPP1 with physiological substrates ATP and ADP

Methods in molecular biology (Clifton, N.J.), 2013, Vol.1053, p.145

2013

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Pathophysiological Role of Vascular Smooth Muscle Alkaline Phosphatase in Medial Artery Calcification

Mechanism of Action and Structure-Activity Relationships of Tetracyclic Small Molecules Acting as Universal Positive Allosteric Modulators of the Cholecystokinin Receptor

Screening for positive allosteric modulators of cholecystokinin type 1 receptor potentially useful for management of obesity

Ebselen inhibits QSOX1 enzymatic activity and suppresses invasion of pancreatic and renal cancer cell lines

Discovery of a Positive Allosteric Modulator of Cholecystokinin Action at CCK1R in Normal and Elevated Cholesterol

Structure-activity relationships of thiadiazole agonists of the human secretin receptor

TR-FRET-based high-throughput screening assay for identification of UBC13 inhibitors

Discovery of small molecule positive allosteric modulators of the secretin receptor

Engineering a leucine zipper-TRAIL homotrimer with improved cytotoxicity in tumor cells

High-throughput screening of tissue-nonspecific alkaline phosphatase for identification of effectors with diverse modes of action

Time-Resolved Fluorescence Assays

Discovery and Validation of a Series of Aryl Sulfonamides as Selective Inhibitors of Tissue-Nonspecific Alkaline Phosphatase (TNAP)

Development of a Testing Funnel for Identification of Small-Molecule Modulators Targeting Secretin Receptors

High-throughput screening for protein tyrosine phosphatase activity modulators

Catalytic Acid−Base Groups in Yeast Pyruvate Decarboxylase. 2. Insights into the Specific Roles of D28 and E477 from the Rates and Stereospecificity of Formation of Carboligase Side Products

Structural and Kinetic Analysis of Catalysis by a Thiamin Diphosphate-Dependent Enzyme, Benzoylformate Decarboxylase

New Model for Activation of Yeast Pyruvate Decarboxylase by Substrate Consistent with the Alternating Sites Mechanism: Demonstration of the Existence of Two Active Forms of the Enzyme

Catalytic Acid−Base Groups in Yeast Pyruvate Decarboxylase. 1. Site-Directed Mutagenesis and Steady-State Kinetic Studies on the Enzyme with the D28A, H114F, H115F, and E477Q Substitutions

Phosphatase high-throughput screening assay design and selection

Catalytic Acid−Base Groups in Yeast Pyruvate Decarboxylase. 3. A Steady-State Kinetic Model Consistent with the Behavior of both Wild-Type and Variant Enzymes at All Relevant pH Values

Spectroscopic Detection of Transient Thiamin Diphosphate-Bound Intermediates on Benzoylformate Decarboxylase

Yeast Pyruvate Decarboxylase Tetramers Can Dissociate into Dimers along Two Interfaces. Hybrids of Low-Activity D28A (or D28N) and E477Q Variants, with Substitution of Adjacent Active Center Acidic Groups from Different Subunits, Display Restored Activity

A method for direct assessment of tissue-nonspecific alkaline phosphatase (TNAP) inhibitors in blood samples

Modulators of intestinal alkaline phosphatase

New activity assays for ENPP1 with physiological substrates ATP and ADP

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