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RPRD1A and RPRD1B are human RNA polymerase II C-terminal domain scaffolds for Ser5 dephosphorylation

Nature structural & molecular biology, 2014-08, Vol.21 (8), p.686-695

2014

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High throughput methods of assessing protein stability and aggregation

Molecular bioSystems, 2009-01, Vol.5 (3), p.217-223

2009

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Application of high-throughput isothermal denaturation to assess protein stability and screen for ligands

Journal of biomolecular screening, 2008-06, Vol.13 (5), p.337-342

2008

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(R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells

Proceedings of the National Academy of Sciences - PNAS, 2014-09, Vol.111 (35), p.12853-12858

2014

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Phosphorylation-independent dual-site binding of the FHA domain of KIF13 mediates phosphoinositide transport via centaurin α1

Proceedings of the National Academy of Sciences - PNAS, 2010-11, Vol.107 (47), p.20346-20351

2010

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Screening for ligands using a generic and high-throughput light-scattering-based assay

Journal of biomolecular screening, 2006-12, Vol.11 (8), p.940-948

2006

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Screening for Inhibitors of Low-Affinity Epigenetic Peptide-Protein Interactions: An AlphaScreen™-Based Assay for Antagonists of Methyl-Lysine Binding Proteins

Journal of biomolecular screening, 2010-01, Vol.15 (1), p.62-71

2010

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Assessing the Stability of Membrane Proteins to Detect Ligand Binding Using Differential Static Light Scattering

Journal of biomolecular screening, 2010-03, Vol.15 (3), p.314-320

2010

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Crystal Structures of Apo Centaurin Alpha1 and its Complex With Phosphatidylinositol 3,4,5-triphosphate

Alzheimer's & dementia, 2010-07, Vol.6 (4), p.e57-e57

2010

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The nuclear matrix is a thermolabile cellular structure

Cell stress & chaperones, 2001-04, Vol.6 (2), p.136-147

2001

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Destabilization of the Ca2+-ATPase of Sarcoplasmic Reticulum by Thiol-Specific, Heat Shock Inducers Results in Thermal Denaturation at 37 °C

Biochemistry (Easton), 1997-09, Vol.36 (36), p.11002-11011

1997

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Phosphorylation-independent dual-site binding of the FHA domain of KIF13 mediates phosphoinositide transport via centaurin [alpha]1

Proceedings of the National Academy of Sciences - PNAS, 2011-11, Vol.107 ((47) ; 11, 2010)

2011

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Phosphorylation-independent dual-site binding of the FHA domain of KIF13 mediates phosphoinositide transport via centaurin [alpha]1

Proceedings of the National Academy of Sciences - PNAS, 2010-11, Vol.107 (47), p.20346

2010

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P4‐119: Crystal Structures of Apo Centaurin Alpha1 and its Complex With Phosphatidylinositol 3,4,5‐triphosphate

Alzheimer's & dementia, 2010-07, Vol.6 (4S_Part_21), p.e57-e57

2010

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Phosphorylation-independent dual-site binding of the FHA domain of KIF13 mediates phosphoinositide transport via centaurin alpha1

Proceedings of the National Academy of Sciences - PNAS, 2010-11, Vol.107 (47), p.20346

2010

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Destabilization and Denaturation of Cellular Protein by Glutathione Depletion

Cell stress & chaperones, 1997-09, Vol.2 (3), p.191-198

1997

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Destabilization of the Ca 2+ -ATPase of Sarcoplasmic Reticulum by Thiol-Specific, Heat Shock Inducers Results in Thermal Denaturation at 37 °C

Biochemistry (Easton), 1997-09, Vol.36 (36), p.11002-11011

1997

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Structure of the catalytic domain of EZH2 reveals conformational plasticity in cofactor and substrate binding sites and explains oncogenic mutations

PloS one, 2013-12, Vol.8 (12), p.e83737

2013

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Thermal denaturation assays in chemical biology

Assay and drug development technologies, 2012-04, Vol.10 (2), p.128-136

2012

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A cellular chemical probe targeting the chromodomains of Polycomb repressive complex 1

Nature chemical biology, 2016-03, Vol.12 (3), p.180-187

2016

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Discovery of a Potent, Selective, and Cell-Active Dual Inhibitor of Protein Arginine Methyltransferase 4 and Protein Arginine Methyltransferase 6

Journal of medicinal chemistry, 2016-10, Vol.59 (19), p.9124-9139

2016

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Conformational dynamics of the TTD–PHD histone reader module of the UHRF1 epigenetic regulator reveals multiple histone-binding states, allosteric regulation, and druggability

The Journal of biological chemistry, 2017-12, Vol.292 (51), p.20947-20959

2017

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Structure-Based Optimization of a Small Molecule Antagonist of the Interaction Between WD Repeat-Containing Protein 5 (WDR5) and Mixed-Lineage Leukemia 1 (MLL1)

Journal of medicinal chemistry, 2016-03, Vol.59 (6), p.2478-2496

2016

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Discovery of a 2,4-Diamino-7-aminoalkoxyquinazoline as a Potent and Selective Inhibitor of Histone Lysine Methyltransferase G9a

Journal of medicinal chemistry, 2009-12, Vol.52 (24), p.7950-7953

2009

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RPRD1A and RPRD1B are human RNA polymerase II C-terminal domain scaffolds for Ser5 dephosphorylation

High throughput methods of assessing protein stability and aggregation

Application of high-throughput isothermal denaturation to assess protein stability and screen for ligands

(R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells

Phosphorylation-independent dual-site binding of the FHA domain of KIF13 mediates phosphoinositide transport via centaurin α1

Screening for ligands using a generic and high-throughput light-scattering-based assay

Screening for Inhibitors of Low-Affinity Epigenetic Peptide-Protein Interactions: An AlphaScreen™-Based Assay for Antagonists of Methyl-Lysine Binding Proteins

Assessing the Stability of Membrane Proteins to Detect Ligand Binding Using Differential Static Light Scattering

Crystal Structures of Apo Centaurin Alpha1 and its Complex With Phosphatidylinositol 3,4,5-triphosphate

The nuclear matrix is a thermolabile cellular structure

Destabilization of the Ca2+-ATPase of Sarcoplasmic Reticulum by Thiol-Specific, Heat Shock Inducers Results in Thermal Denaturation at 37 °C

Phosphorylation-independent dual-site binding of the FHA domain of KIF13 mediates phosphoinositide transport via centaurin [alpha]1

Phosphorylation-independent dual-site binding of the FHA domain of KIF13 mediates phosphoinositide transport via centaurin [alpha]1

P4‐119: Crystal Structures of Apo Centaurin Alpha1 and its Complex With Phosphatidylinositol 3,4,5‐triphosphate

Phosphorylation-independent dual-site binding of the FHA domain of KIF13 mediates phosphoinositide transport via centaurin alpha1

Destabilization and Denaturation of Cellular Protein by Glutathione Depletion

Destabilization of the Ca 2+ -ATPase of Sarcoplasmic Reticulum by Thiol-Specific, Heat Shock Inducers Results in Thermal Denaturation at 37 °C

The EED protein-protein interaction inhibitor A-395 inactivates the PRC2 complex

Structure of the catalytic domain of EZH2 reveals conformational plasticity in cofactor and substrate binding sites and explains oncogenic mutations

Thermal denaturation assays in chemical biology

A cellular chemical probe targeting the chromodomains of Polycomb repressive complex 1

Discovery of a Potent, Selective, and Cell-Active Dual Inhibitor of Protein Arginine Methyltransferase 4 and Protein Arginine Methyltransferase 6

Conformational dynamics of the TTD–PHD histone reader module of the UHRF1 epigenetic regulator reveals multiple histone-binding states, allosteric regulation, and druggability

Structure-Based Optimization of a Small Molecule Antagonist of the Interaction Between WD Repeat-Containing Protein 5 (WDR5) and Mixed-Lineage Leukemia 1 (MLL1)

Discovery of a 2,4-Diamino-7-aminoalkoxyquinazoline as a Potent and Selective Inhibitor of Histone Lysine Methyltransferase G9a

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