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Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics

Oncogene, 2010-02, Vol.29 (5), p.625-634

SEMENZA, G. L

2010

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Cancer-stromal cell interactions mediated by hypoxia-inducible factors promote angiogenesis, lymphangiogenesis, and metastasis

Oncogene, 2013-08, Vol.32 (35), p.4057-4063

Semenza, G L

2013

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Regulation of metabolism by hypoxia-inducible factor 1

Cold Spring Harbor Symposia on Quantitative Biology, 2011, Vol.76, p.347-353

Semenza, G L

2011

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HIF-1 and mechanisms of hypoxia sensing

Current Opinion in Cell Biology, 2001-04, Vol.13 (2), p.167-171

Semenza, Gregg L

2001

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Targeting HIF-1 for cancer therapy

Nature reviews. Cancer, 2003-10, Vol.3 (10), p.721-732

Semenza, Gregg L

2003

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HIF-1 and human disease: one highly involved factor

Genes & development, 2000-08, Vol.14 (16), p.1983-1991

Semenza, G L

2000

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HIF-1: mediator of physiological and pathophysiological responses to hypoxia

Journal of applied physiology (1985), 2000-04, Vol.88 (4), p.1474-1480

Semenza, Gregg L

2000

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HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs

Oncogene, 2012-04, Vol.31 (14), p.1757-1770

2012

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Expression of hypoxia-inducible factor 1: mechanisms and consequences

Biochemical pharmacology, 2000, Vol.59 (1), p.47-53

Semenza, Gregg L

2000

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Retraction Note: HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs

Oncogene, 2023-07, Vol.42 (28), p.2234-2234

2023

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FIH-1: a novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity

Genes & development, 2001-10, Vol.15 (20), p.2675-2686

2001

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Correction: HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs

Oncogene, 2021-02, Vol.40 (8), p.1552-1553

2021

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HIF-1 inhibitors for cancer therapy: from gene expression to drug discovery

Current pharmaceutical design, 2009-11, Vol.15 (33), p.3839

Semenza, G L

2009

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SAG ROC2 RBX2 is a HIF-1 target gene that promotes HIF-1α ubiquitination and degradation

Oncogene, 2008-02, Vol.27 (10), p.1404-1411

2008

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Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension

American Journal of Physiology: Cell Physiology, 1996-10, Vol.271 (4), p.C1172-C1180

1996

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Modulation of hypoxia-inducible factor 1α expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells : Implications for tumor angiogenesis and therapeutics

Cancer research (Chicago, Ill.), 2000-03, Vol.60 (6), p.1541-1545

2000

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Up-regulation of gene expression by hypoxia is mediated predominantly by hypoxia-inducible factor 1 (HIF-1)

The Journal of pathology, 2005-07, Vol.206 (3), p.291-304

2005

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Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1

Molecular and Cellular Biology, 1996-09, Vol.16 (9), p.4604-4613

1996

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HIF-1: using two hands to flip the angiogenic switch

Cancer and metastasis reviews, 2000, Vol.19 (1-2), p.59-65

Semenza, G L

2000

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REGULATION OF MAMMALIAN O2 HOMEOSTASIS BY HYPOXIA-INDUCIBLE FACTOR 1

Annual review of cell and developmental biology, 1999, Vol.15 (1), p.551-578

Semenza, Gregg L

1999

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A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation

Molecular and Cellular Biology, 1992-12, Vol.12 (12), p.5447-5454

1992

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Desferrioxamine Induces Erythropoietin Gene Expression and Hypoxia-Inducible Factor 1 DNA-Binding Activity: Implications for Models of Hypoxia Signal Transduction

Blood, 1993-12, Vol.82 (12), p.3610-3615

1993

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Reciprocal positive regulation of hypoxia-inducible factor 1α and insulin-like growth factor 2

Cancer research (Chicago, Ill.), 1999-08, Vol.59 (16), p.3915-3918

1999

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V-SRC induces expression of hypoxia-inducible factor 1 (HIF-1) and transcription of genes encoding vascular endothelial growth factor and enolase 1: Involvement of HIF-1 in tumor progression

Cancer research (Chicago, Ill.), 1997-12, Vol.57 (23), p.5328-5335

1997

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General Involvement of Hypoxia-Inducible Factor 1 in Transcriptional Response to Hypoxia

Proceedings of the National Academy of Sciences - PNAS, 1993-05, Vol.90 (9), p.4304-4308

1993

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Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics

Cancer-stromal cell interactions mediated by hypoxia-inducible factors promote angiogenesis, lymphangiogenesis, and metastasis

Regulation of metabolism by hypoxia-inducible factor 1

HIF-1 and mechanisms of hypoxia sensing

Targeting HIF-1 for cancer therapy

HIF-1 and human disease: one highly involved factor

HIF-1: mediator of physiological and pathophysiological responses to hypoxia

HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs

Expression of hypoxia-inducible factor 1: mechanisms and consequences

Retraction Note: HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs

FIH-1: a novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity

Correction: HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs

HIF-1 inhibitors for cancer therapy: from gene expression to drug discovery

SAG ROC2 RBX2 is a HIF-1 target gene that promotes HIF-1α ubiquitination and degradation

Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension

Modulation of hypoxia-inducible factor 1α expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells : Implications for tumor angiogenesis and therapeutics

Up-regulation of gene expression by hypoxia is mediated predominantly by hypoxia-inducible factor 1 (HIF-1)

Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1

HIF-1: using two hands to flip the angiogenic switch

REGULATION OF MAMMALIAN O2 HOMEOSTASIS BY HYPOXIA-INDUCIBLE FACTOR 1

A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation

Desferrioxamine Induces Erythropoietin Gene Expression and Hypoxia-Inducible Factor 1 DNA-Binding Activity: Implications for Models of Hypoxia Signal Transduction

Reciprocal positive regulation of hypoxia-inducible factor 1α and insulin-like growth factor 2

V-SRC induces expression of hypoxia-inducible factor 1 (HIF-1) and transcription of genes encoding vascular endothelial growth factor and enolase 1: Involvement of HIF-1 in tumor progression

General Involvement of Hypoxia-Inducible Factor 1 in Transcriptional Response to Hypoxia

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