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Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics

Oncogene, 2010-02, Vol.29 (5), p.625-634

Semenza, G L

2010

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Cancer–stromal cell interactions mediated by hypoxia-inducible factors promote angiogenesis, lymphangiogenesis, and metastasis

Oncogene, 2013-08, Vol.32 (35), p.4057-4063

Semenza, G L

2013

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Regulation of metabolism by hypoxia-inducible factor 1

Cold Spring Harbor Symposia on Quantitative Biology, 2011, Vol.76, p.347-353

Semenza, G L

2011

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HIF-1 inhibitors for cancer therapy: from gene expression to drug discovery

Current pharmaceutical design, 2009-11, Vol.15 (33), p.3839-3843

Semenza, G L

2009

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Targeting HIF-1 for cancer therapy

Nature reviews. Cancer, 2003-10, Vol.3 (10), p.721-732

Semenza, Gregg L

2003

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Evaluation of HIF-1 inhibitors as anticancer agents

Drug discovery today, 2007-10, Vol.12 (19), p.853-859

Semenza, Gregg L.

2007

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HIF-1 and mechanisms of hypoxia sensing

Current Opinion in Cell Biology, 2001-04, Vol.13 (2), p.167-171

Semenza, Gregg L

2001

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HIF-1: mediator of physiological and pathophysiological responses to hypoxia

Journal of applied physiology (1985), 2000-04, Vol.88 (4), p.1474-1480

Semenza, Gregg L

2000

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HIF-1 and human disease: one highly involved factor

Genes & development, 2000-08, Vol.14 (16), p.1983-1991

Semenza, G L

2000

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HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs

Oncogene, 2012-04, Vol.31 (14), p.1757-1770

2012

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REGULATION OF MAMMALIAN O2 HOMEOSTASIS BY HYPOXIA-INDUCIBLE FACTOR 1

Annual review of cell and developmental biology, 1999, Vol.15 (1), p.551-578

Semenza, Gregg L

1999

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Expression of hypoxia-inducible factor 1: mechanisms and consequences

Biochemical pharmacology, 2000, Vol.59 (1), p.47-53

Semenza, Gregg L

2000

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FIH-1: a novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity

Genes & development, 2001-10, Vol.15 (20), p.2675-2686

2001

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Retraction Note: HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs

Oncogene, 2023-07, Vol.42 (28), p.2234-2234

2023

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Hypoxia-inducible factor 1: oxygen homeostasis and disease pathophysiology

Trends in Molecular Medicine, 2001-08, Vol.7 (8), p.345-350

Semenza, Gregg L.

2001

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Modulation of hypoxia-inducible factor 1α expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells : Implications for tumor angiogenesis and therapeutics

Cancer research (Chicago, Ill.), 2000-03, Vol.60 (6), p.1541-1545

2000

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Hypoxia-inducible factor 1: Control of oxygen homeostasis in health and disease

Pediatric research, 2001-05, Vol.49 (5), p.614-617

SEMENZA, Gregg L

2001

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Correction: HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs

Oncogene, 2021-02, Vol.40 (8), p.1552-1553

2021

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Up-regulation of gene expression by hypoxia is mediated predominantly by hypoxia-inducible factor 1 (HIF-1)

The Journal of pathology, 2005-07, Vol.206 (3), p.291-304

2005

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Oxygen sensing in the body

Progress in biophysics and molecular biology, 2006-07, Vol.91 (3), p.249-286

2006

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SAG ROC2 RBX2 is a HIF-1 target gene that promotes HIF-1α ubiquitination and degradation

Oncogene, 2008-02, Vol.27 (10), p.1404-1411

2008

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HIF-1: using two hands to flip the angiogenic switch

Cancer and metastasis reviews, 2000, Vol.19 (1-2), p.59-65

Semenza, G L

2000

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Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension

American Journal of Physiology: Cell Physiology, 1996-10, Vol.271 (4), p.C1172-C1180

1996

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Targeting Stat3 blocks both HIF-1 and VEGF expression induced by multiple oncogenic growth signaling pathways

Oncogene, 2005-08, Vol.24 (36), p.5552-5560

2005

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Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1

Molecular and Cellular Biology, 1996-09, Vol.16 (9), p.4604-4613

1996

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Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics

Cancer–stromal cell interactions mediated by hypoxia-inducible factors promote angiogenesis, lymphangiogenesis, and metastasis

Regulation of metabolism by hypoxia-inducible factor 1

HIF-1 inhibitors for cancer therapy: from gene expression to drug discovery

Targeting HIF-1 for cancer therapy

Evaluation of HIF-1 inhibitors as anticancer agents

HIF-1 and mechanisms of hypoxia sensing

HIF-1: mediator of physiological and pathophysiological responses to hypoxia

HIF-1 and human disease: one highly involved factor

HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs

REGULATION OF MAMMALIAN O2 HOMEOSTASIS BY HYPOXIA-INDUCIBLE FACTOR 1

Expression of hypoxia-inducible factor 1: mechanisms and consequences

FIH-1: a novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity

Retraction Note: HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs

Hypoxia-inducible factor 1: oxygen homeostasis and disease pathophysiology

Modulation of hypoxia-inducible factor 1α expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells : Implications for tumor angiogenesis and therapeutics

Hypoxia-inducible factor 1: Control of oxygen homeostasis in health and disease

Correction: HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs

Up-regulation of gene expression by hypoxia is mediated predominantly by hypoxia-inducible factor 1 (HIF-1)

Oxygen sensing in the body

SAG ROC2 RBX2 is a HIF-1 target gene that promotes HIF-1α ubiquitination and degradation

HIF-1: using two hands to flip the angiogenic switch

Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension

Targeting Stat3 blocks both HIF-1 and VEGF expression induced by multiple oncogenic growth signaling pathways

Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1

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