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Inhibition of miR-146a Expression and Regulation of Endotoxin Tolerance by Rhesus Theta-Defensin-1

Mediators of inflammation, 2023-04, Vol.2023, p.8387330-8

2023

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An ADAM10 Exosite Inhibitor Is Efficacious in an In Vivo Collagen-Induced Arthritis Model

Pharmaceuticals (Basel, Switzerland), 2024-01, Vol.17 (1), p.87

2024

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Antimicrobial Peptides from Human Platelets

Infection and Immunity, 2002-12, Vol.70 (12), p.6524-6533

2002

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Criterion for Amino Acid Composition of Defensins and Antimicrobial Peptides Based on Geometry of Membrane Destabilization

Journal of the American Chemical Society, 2011-05, Vol.133 (17), p.6720-6727

2011

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A host-directed macrocyclic peptide therapeutic for MDR gram negative bacterial infections

Scientific reports, 2021-12, Vol.11 (1), p.23447-23447, Article 23447

2021

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Rhesus macaque theta defensins suppress inflammatory cytokines and enhance survival in mouse models of bacteremic sepsis

PloS one, 2012-12, Vol.7 (12), p.e51337

2012

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Rhesus Theta-Defensin Prevents Death in a Mouse Model of Severe Acute Respiratory Syndrome Coronavirus Pulmonary Disease

Journal of Virology, 2009-11, Vol.83 (21), p.11385-11390

2009

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Suppression and resolution of autoimmune arthritis by rhesus θ-defensin-1, an immunomodulatory macrocyclic peptide

PloS one, 2017-11, Vol.12 (11), p.e0187868

2017

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Isolation, Synthesis, and Antimicrobial Activities of Naturally Occurring θ-Defensin Isoforms from Baboon Leukocytes

Infection and Immunity, 2008-12, Vol.76 (12), p.5883-5891

2008

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Cyclic and acyclic defensins inhibit human immunodeficiency virus type-1 replication by different mechanisms

PloS one, 2010-03, Vol.5 (3), p.e9737

2010

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Mammalian defensins in the antimicrobial immune response

Nature immunology, 2005-06, Vol.6 (6), p.551-557

2005

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Host Defense Peptides as Templates for Antifungal Drug Development

Journal of fungi (Basel), 2020-10, Vol.6 (4), p.241

2020

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Microbicidal Properties and Cytocidal Selectivity of Rhesus Macaque Theta Defensins

Antimicrobial Agents and Chemotherapy, 2008-03, Vol.52 (3), p.944-953

2008

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θ-Defensins: Cyclic Peptides with Endless Potential

The Journal of biological chemistry, 2012-08, Vol.287 (32), p.27014-27019

2012

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Rhesus macaque θ-defensin isoforms: expression, antimicrobial activities, and demonstration of a prominent role in neutrophil granule microbicidal activities

Journal of leukocyte biology, 2011-02, Vol.89 (2), p.283-290

2011

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High fidelity processing and activation of the human α-defensin HNP1 precursor by neutrophil elastase and proteinase 3

PloS one, 2012-03, Vol.7 (3), p.e32469-e32469

2012

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Anti-Inflammatory Effects of RTD-1 in a Murine Model of Chronic Pseudomonas aeruginosa Lung Infection: Inhibition of NF-κB, Inflammasome Gene Expression, and Pro-IL-1β Biosynthesis

Antibiotics (Basel), 2021-08, Vol.10 (9), p.1043

2021

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Killing of staphylococci by θ-defensins involves membrane impairment and activation of autolytic enzymes

Antibiotics (Basel), 2014-11, Vol.3 (4), p.617-631

2014

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Preclinical Pharmacokinetics and Safety of Intravenous RTD-1

Antimicrobial agents and chemotherapy, 2022-03, Vol.66 (3), p.e0212521-e0212521

2022

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Fungicidal Potency and Mechanisms of θ-Defensins against Multidrug-Resistant Candida Species

Antimicrobial agents and chemotherapy, 2018-06, Vol.62 (6)

2018

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Essential role of IFN-γ in T cell-associated intestinal inflammation

JCI insight, 2018-09, Vol.3 (18)

2018

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Structure, function, and membrane integration of defensins

Current opinion in structural biology, 1995-08, Vol.5 (4), p.521-527

1995

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Anti-HIV-1 activity of indolicidin, an antimicrobial peptide from neutrophils

Journal of leukocyte biology, 1998-01, Vol.63 (1), p.94-100

1998

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Macrocyclic θ-defensins suppress tumor necrosis factor-α (TNF-α) shedding by inhibition of TNF-α–converting enzyme

The Journal of biological chemistry, 2018-02, Vol.293 (8), p.2725-2734

2018

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Rhesus macaque θ‐defensin RTD‐1 inhibits proinflammatory cytokine secretion and gene expression by inhibiting the activation of NF‐κB and MAPK pathways

Journal of leukocyte biology, 2015-12, Vol.98 (6), p.1061-1070

2015

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Inhibition of miR-146a Expression and Regulation of Endotoxin Tolerance by Rhesus Theta-Defensin-1

An ADAM10 Exosite Inhibitor Is Efficacious in an In Vivo Collagen-Induced Arthritis Model

Antimicrobial Peptides from Human Platelets

Criterion for Amino Acid Composition of Defensins and Antimicrobial Peptides Based on Geometry of Membrane Destabilization

A host-directed macrocyclic peptide therapeutic for MDR gram negative bacterial infections

Rhesus macaque theta defensins suppress inflammatory cytokines and enhance survival in mouse models of bacteremic sepsis

Rhesus Theta-Defensin Prevents Death in a Mouse Model of Severe Acute Respiratory Syndrome Coronavirus Pulmonary Disease

Suppression and resolution of autoimmune arthritis by rhesus θ-defensin-1, an immunomodulatory macrocyclic peptide

Isolation, Synthesis, and Antimicrobial Activities of Naturally Occurring θ-Defensin Isoforms from Baboon Leukocytes

Cyclic and acyclic defensins inhibit human immunodeficiency virus type-1 replication by different mechanisms

Mammalian defensins in the antimicrobial immune response

Host Defense Peptides as Templates for Antifungal Drug Development

Microbicidal Properties and Cytocidal Selectivity of Rhesus Macaque Theta Defensins

θ-Defensins: Cyclic Peptides with Endless Potential

Rhesus macaque θ-defensin isoforms: expression, antimicrobial activities, and demonstration of a prominent role in neutrophil granule microbicidal activities

High fidelity processing and activation of the human α-defensin HNP1 precursor by neutrophil elastase and proteinase 3

Anti-Inflammatory Effects of RTD-1 in a Murine Model of Chronic Pseudomonas aeruginosa Lung Infection: Inhibition of NF-κB, Inflammasome Gene Expression, and Pro-IL-1β Biosynthesis

Killing of staphylococci by θ-defensins involves membrane impairment and activation of autolytic enzymes

Preclinical Pharmacokinetics and Safety of Intravenous RTD-1

Fungicidal Potency and Mechanisms of θ-Defensins against Multidrug-Resistant Candida Species

Essential role of IFN-γ in T cell-associated intestinal inflammation

Structure, function, and membrane integration of defensins

Anti-HIV-1 activity of indolicidin, an antimicrobial peptide from neutrophils

Macrocyclic θ-defensins suppress tumor necrosis factor-α (TNF-α) shedding by inhibition of TNF-α–converting enzyme

Rhesus macaque θ‐defensin RTD‐1 inhibits proinflammatory cytokine secretion and gene expression by inhibiting the activation of NF‐κB and MAPK pathways

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