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In vitro and in vivo evaluation of dihydropyrimidinone C-5 amides as potent and selective alpha(1A) receptor antagonists for the treatment of benign prostatic hyperplasia

Journal of medicinal chemistry, 2000-07, Vol.43 (14), p.2703-2718

2000

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Cardiac Electrophysiologic and Inotropic Actions of New and Potent Methanesulfonanilide Class III Antiarrhythmic Agents in Anesthetized Dogs

Journal of cardiovascular pharmacology, 1991-11, Vol.18 (5), p.687-695

1991

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Suppression of Lethal Ischemic Ventricular Arrhythmias by the Class III Agent E4031 in a Canine Model of Previous Myocardial Infarction

Journal of cardiovascular pharmacology, 1990-05, Vol.15 (5), p.764-775

1990

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Effects of New and Potent Methanesulfonanilide Class III Antiarrhythmic Agents on Myocardial Refractoriness and Contractility in Isolated Cardiac Muscle

Journal of cardiovascular pharmacology, 1991-09, Vol.18 (3), p.406-414

1991

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Discovery and initial structure–Activity relationships of trisubstituted ureas as thrombin receptor (PAR-1) antagonists

Bioorganic & medicinal chemistry letters, 2001-10, Vol.11 (20), p.2691-2696

2001

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The total synthesis of avermectin A1a

Journal of the American Chemical Society, 1989-04, Vol.111 (8), p.2967-2980

1989

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The synthesis of dihydrofurano[2,3-b]thiopyrans, thiepins and thiophenes

Tetrahedron letters, 1989, Vol.30 (48), p.6607-6610

1989

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A short radiosynthesis of 6-[C3H3]-dorzolamide at very high specific activity and optical purity

Journal of labelled compounds & radiopharmaceuticals, 1996-11, Vol.38 (11), p.963-970

1996

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Total synthesis of (.+-.)-gnididione and (.+-.)-isognididione

Journal of organic chemistry, 1990, Vol.55 (1), p.202-209

1990

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Total synthesis of zincophorin

Journal of the American Chemical Society, 1988-06, Vol.110 (13), p.4368-4378

1988

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An Improved Procedure for the Cyanation of Aryl Triflates: A Convenient Synthesis of 6-Cyano-1,2,3,4-Tetrahydroisoquinoline

Synthetic communications, 1995-10, Vol.25 (20), p.3255-3261

1995

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The total synthesis of the aglycon of avermectin A1a

Journal of the American Chemical Society, 1987-12, Vol.109 (26), p.8117-8119

1987

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A facile three-step synthesis of 1,2-amino alcohols using the Ellman homochiral tert-butylsulfinamide

Tetrahedron letters, 2001-03, Vol.42 (11), p.2051-2054

2001

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Discovery and Evaluation of Potent P 1 Aryl Heterocycle-Based Thrombin Inhibitors

Journal of medicinal chemistry, 2004-06, Vol.47 (12), p.2995-3008

2004

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The total synthesis of avermectin A1a. New protocols for the synthesis of novel 2-deoxypyranose systems and their axial glycosides

Journal of the American Chemical Society, 1987-12, Vol.109 (26), p.8119-8120

1987

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9-Hydroxyazafluorenes and Their Use in Thrombin Inhibitors

Journal of medicinal chemistry, 2005-04, Vol.48 (7), p.2282-2293

2005

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Preparation and trapping of 3-lithium-O-lithiophenoxide

Tetrahedron letters, 1993-03, Vol.34 (13), p.2043-2046

1993

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Synthesis and Evaluation of Imidazole Acetic Acid Inhibitors of Activated Thrombin-Activatable Fibrinolysis Inhibitor as Novel Antithrombotics

Journal of medicinal chemistry, 2003-12, Vol.46 (25), p.5294-5297

2003

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Antiarrhythmic efficacy of selective blockade of the cardiac slowly activating delayed rectifier current, I(Ks), in canine models of malignant ischemic ventricular arrhythmia

Circulation (New York, N.Y.), 1999-11, Vol.100 (18), p.1917-1922

1999

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Potent thrombin inhibitors via a 20-membered ring olefin metathesis macrocyclization

Tetrahedron letters, 2003-03, Vol.44 (11), p.2401-2404

2003

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The synthesis of dihydrothieno[2,3-b]thiophenes by a metal-halogen exchange initiated intramolecular acylation

Tetrahedron letters, 1991-02, Vol.32 (6), p.721-724

1991

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The total synthesis of zincophorin

Journal of the American Chemical Society, 1987-03, Vol.109 (5), p.1572-1574

1987

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A systematic degradation of zincophorin: a stereoselective synthesis of the C17-C25 fragment

Journal of organic chemistry, 1986-12, Vol.51 (25), p.5032-5036

1986

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Design and Synthesis of Potent, Selective, and Orally Bioavailable Tetrasubstituted Imidazole Inhibitors of p38 Mitogen-Activated Protein Kinase

In vitro and in vivo evaluation of dihydropyrimidinone C-5 amides as potent and selective alpha(1A) receptor antagonists for the treatment of benign prostatic hyperplasia

Cardiac Electrophysiologic and Inotropic Actions of New and Potent Methanesulfonanilide Class III Antiarrhythmic Agents in Anesthetized Dogs

Suppression of Lethal Ischemic Ventricular Arrhythmias by the Class III Agent E4031 in a Canine Model of Previous Myocardial Infarction

Effects of New and Potent Methanesulfonanilide Class III Antiarrhythmic Agents on Myocardial Refractoriness and Contractility in Isolated Cardiac Muscle

Discovery and initial structure–Activity relationships of trisubstituted ureas as thrombin receptor (PAR-1) antagonists

The total synthesis of avermectin A1a

The synthesis of dihydrofurano[2,3-b]thiopyrans, thiepins and thiophenes

A short radiosynthesis of 6-[C3H3]-dorzolamide at very high specific activity and optical purity

Total synthesis of (.+-.)-gnididione and (.+-.)-isognididione

Total synthesis of zincophorin

An Improved Procedure for the Cyanation of Aryl Triflates: A Convenient Synthesis of 6-Cyano-1,2,3,4-Tetrahydroisoquinoline

The total synthesis of the aglycon of avermectin A1a

A facile three-step synthesis of 1,2-amino alcohols using the Ellman homochiral tert-butylsulfinamide

Discovery and Evaluation of Potent P 1 Aryl Heterocycle-Based Thrombin Inhibitors

Class III Antiarrhythmic Activity in Vivo by Selective Blockade of the Slowly Activating Cardiac Delayed Rectifier Potassium Current IKs by (R)-2-(2,4- Trifluoromethyl)-N-[2-oxo-5-phenyl- 1-(2,2,2-trifluoroethyl)-2,3-dihydro- 1H-benzo[e][1,4]diazepin-3-yl]acetamide

The total synthesis of avermectin A1a. New protocols for the synthesis of novel 2-deoxypyranose systems and their axial glycosides

9-Hydroxyazafluorenes and Their Use in Thrombin Inhibitors

Preparation and trapping of 3-lithium-O-lithiophenoxide

Synthesis and Evaluation of Imidazole Acetic Acid Inhibitors of Activated Thrombin-Activatable Fibrinolysis Inhibitor as Novel Antithrombotics

Antiarrhythmic efficacy of selective blockade of the cardiac slowly activating delayed rectifier current, I(Ks), in canine models of malignant ischemic ventricular arrhythmia

Potent thrombin inhibitors via a 20-membered ring olefin metathesis macrocyclization

The synthesis of dihydrothieno[2,3-b]thiophenes by a metal-halogen exchange initiated intramolecular acylation

The total synthesis of zincophorin

A systematic degradation of zincophorin: a stereoselective synthesis of the C17-C25 fragment

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