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Novel Chimeric Histone Deacetylase Inhibitors: A Series of Lapatinib Hybrides as Potent Inhibitors of Epidermal Growth Factor Receptor (EGFR), Human Epidermal Growth Factor Receptor 2 (HER2), and Histone Deacetylase Activity

Journal of medicinal chemistry, 2010-12, Vol.53 (24), p.8546-8555

2010

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HDAC3 Activity is Essential for Human Leukemic Cell Growth and the Expression of β-catenin, MYC, and WT1

Cancers, 2019-09, Vol.11 (10), p.1436

2019

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Drugging the HDAC6–HSP90 interplay in malignant cells

Trends in pharmacological sciences (Regular ed.), 2014-10, Vol.35 (10), p.501-509

2014

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Chimerically designed HDAC- and tyrosine kinase inhibitors. A series of erlotinib hybrids as dual-selective inhibitors of EGFR, HER2 and histone deacetylases

MedChemComm, 2012-07, Vol.3 (7), p.829

2012

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Generation and Assessment of Fusions Between HDACi and TKi

Methods in molecular biology (Clifton, N.J.), 2017, Vol.1510, p.405

2017

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Inhibition of FLT3 and PDGFR tyrosine kinase activity by bis(benzo[ b]furan-2-yl)methanones

Bioorganic & medicinal chemistry, 2007-03, Vol.15 (5), p.2187-2197

2007

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Design and biological evaluation of tetrahydro-β-carboline derivatives as highly potent histone deacetylase 6 (HDAC6) inhibitors

European journal of medicinal chemistry, 2018-05, Vol.152, p.329-357

2018

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Biological and structural investigation of tetrahydro-β-carboline-based selective HDAC6 inhibitors with improved stability

European journal of medicinal chemistry, 2024-10, Vol.276, p.116676, Article 116676

2024

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Enantioselective synthesis and biological investigation of tetrahydro‐β‐carboline‐based HDAC6 inhibitors with improved solubility

Archiv der Pharmazie (Weinheim), 2019-06, Vol.352 (6), p.e1900026-n/a

2019

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Potential Antipsoriatic Agents: Lapacho Compounds as Potent Inhibitors of HaCaT Cell Growth

Journal of natural products (Washington, D.C.), 1999-08, Vol.62 (8), p.1134-1136

1999

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Marbostat-100 Defines a New Class of Potent and Selective Antiinflammatory and Antirheumatic Histone Deacetylase 6 Inhibitors

Journal of medicinal chemistry, 2018-04, Vol.61 (8), p.3454-3477

2018

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Identification of a highly efficient dual type I/II FMS-like tyrosine kinase inhibitor that disrupts the growth of leukemic cells

Cell chemical biology, 2022-03, Vol.29 (3), p.398-411.e4

2022

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HSP90 is necessary for the ACK1-dependent phosphorylation of STAT1 and STAT3

Cellular signalling, 2017-11, Vol.39, p.9-17

2017

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Class I histone deacetylases regulate p53/NF-κB crosstalk in cancer cells

Cellular signalling, 2017-01, Vol.29, p.218-225

2017

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A novel Cereblon E3 ligase modulator with antitumor activity in gastrointestinal cancer

Bioorganic chemistry, 2022-02, Vol.119, p.105505, Article 105505

2022

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A series of novel aryl-methanone derivatives as inhibitors of FMS-like tyrosine kinase 3 (FLT3) in FLT3-ITD-positive acute myeloid leukemia

European journal of medicinal chemistry, 2020-05, Vol.193, p.112232, Article 112232

2020

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Inhibitors of class I HDACs and of FLT3 combine synergistically against leukemia cells with mutant FLT3

Archives of toxicology, 2022-01, Vol.96 (1), p.177-193

2022

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Design of Chimeric Histone Deacetylase- and Tyrosine Kinase-Inhibitors: A Series of Imatinib Hybrides as Potent Inhibitors of Wild-Type and Mutant BCR-ABL, PDGF-Rβ, and Histone Deacetylases

Journal of medicinal chemistry, 2009-04, Vol.52 (8), p.2265-2279

2009

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Corrigendum to “A novel Cereblon E3 ligase modulator with antitumor activity in gastrointestinal cancer” [Bioorgan. Chem. 119 (2022) 105505]

Bioorganic chemistry, 2024-05, Vol.146, p.107248-107248, Article 107248

2024

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Analysis of the interplay between all-trans retinoic acid and histone deacetylase inhibitors in leukemic cells

Archives of toxicology, 2017-05, Vol.91 (5), p.2191-2208

2017

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3-Bromo-4-(1H-3-indolyl)-2,5-dihydro-1H-2,5-pyrroledione derivatives as new lead compounds for antibacterially active substances

European journal of medicinal chemistry, 2006-02, Vol.41 (2), p.176-191

2006

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Human platelet lysate as validated replacement for animal serum to assess chemosensitivity

ALTEX, alternatives to animal experimentation, 2019-01, Vol.36 (2), p.277-288

2019

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2-Aroylindoles and 2-Aroylbenzofurans with N-Hydroxyacrylamide Substructures as a Novel Series of Rationally Designed Histone Deacetylase Inhibitors

Journal of medicinal chemistry, 2007-09, Vol.50 (18), p.4405-4418

2007

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2-Arylamino-4-Amino-5-Aroylthiazoles. “One-Pot” Synthesis and Biological Evaluation of a New Class of Inhibitors of Tubulin Polymerization

Journal of medicinal chemistry, 2009-09, Vol.52 (17), p.5551-5555

2009

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Novel inhibitors of epidermal growth factor receptor: (4-(Arylamino)-7H-pyrrolo[2,3-d]pyrimidin-6-yl)(1H-indol-2-yl)methanones and (1H-indol-2-yl)(4-(phenylamino)thieno[2,3-d]pyrimidin-6-yl)methanones

Bioorganic & medicinal chemistry, 2012-01, Vol.20 (1), p.125-136

2012

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Novel Chimeric Histone Deacetylase Inhibitors: A Series of Lapatinib Hybrides as Potent Inhibitors of Epidermal Growth Factor Receptor (EGFR), Human Epidermal Growth Factor Receptor 2 (HER2), and Histone Deacetylase Activity

HDAC3 Activity is Essential for Human Leukemic Cell Growth and the Expression of β-catenin, MYC, and WT1

Drugging the HDAC6–HSP90 interplay in malignant cells

Chimerically designed HDAC- and tyrosine kinase inhibitors. A series of erlotinib hybrids as dual-selective inhibitors of EGFR, HER2 and histone deacetylases

Generation and Assessment of Fusions Between HDACi and TKi

Inhibition of FLT3 and PDGFR tyrosine kinase activity by bis(benzo[ b]furan-2-yl)methanones

Design and biological evaluation of tetrahydro-β-carboline derivatives as highly potent histone deacetylase 6 (HDAC6) inhibitors

Biological and structural investigation of tetrahydro-β-carboline-based selective HDAC6 inhibitors with improved stability

Enantioselective synthesis and biological investigation of tetrahydro‐β‐carboline‐based HDAC6 inhibitors with improved solubility

Potential Antipsoriatic Agents: Lapacho Compounds as Potent Inhibitors of HaCaT Cell Growth

Marbostat-100 Defines a New Class of Potent and Selective Antiinflammatory and Antirheumatic Histone Deacetylase 6 Inhibitors

Identification of a highly efficient dual type I/II FMS-like tyrosine kinase inhibitor that disrupts the growth of leukemic cells

HSP90 is necessary for the ACK1-dependent phosphorylation of STAT1 and STAT3

Class I histone deacetylases regulate p53/NF-κB crosstalk in cancer cells

A novel Cereblon E3 ligase modulator with antitumor activity in gastrointestinal cancer

A series of novel aryl-methanone derivatives as inhibitors of FMS-like tyrosine kinase 3 (FLT3) in FLT3-ITD-positive acute myeloid leukemia

Inhibitors of class I HDACs and of FLT3 combine synergistically against leukemia cells with mutant FLT3

Design of Chimeric Histone Deacetylase- and Tyrosine Kinase-Inhibitors: A Series of Imatinib Hybrides as Potent Inhibitors of Wild-Type and Mutant BCR-ABL, PDGF-Rβ, and Histone Deacetylases

Corrigendum to “A novel Cereblon E3 ligase modulator with antitumor activity in gastrointestinal cancer” [Bioorgan. Chem. 119 (2022) 105505]

Analysis of the interplay between all-trans retinoic acid and histone deacetylase inhibitors in leukemic cells

3-Bromo-4-(1H-3-indolyl)-2,5-dihydro-1H-2,5-pyrroledione derivatives as new lead compounds for antibacterially active substances

Human platelet lysate as validated replacement for animal serum to assess chemosensitivity

2-Aroylindoles and 2-Aroylbenzofurans with N-Hydroxyacrylamide Substructures as a Novel Series of Rationally Designed Histone Deacetylase Inhibitors

2-Arylamino-4-Amino-5-Aroylthiazoles. “One-Pot” Synthesis and Biological Evaluation of a New Class of Inhibitors of Tubulin Polymerization

Novel inhibitors of epidermal growth factor receptor: (4-(Arylamino)-7H-pyrrolo[2,3-d]pyrimidin-6-yl)(1H-indol-2-yl)methanones and (1H-indol-2-yl)(4-(phenylamino)thieno[2,3-d]pyrimidin-6-yl)methanones

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