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Hepatoselectivity of statins: Design and synthesis of 4-sulfamoyl pyrroles as HMG-CoA reductase inhibitors

Bioorganic & medicinal chemistry, 2008-02, Vol.18 (3), p.1151-1156

2008

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Design and synthesis of hepatoselective, pyrrole-based HMG-CoA reductase inhibitors

Bioorganic & medicinal chemistry letters, 2007-08, Vol.17 (16), p.4538-4544

2007

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CI-1011 lowers lipoprotein(a) and plasma cholesterol concentrations in chow-fed cynomolgus monkeys

Atherosclerosis, 1998, Vol.136 (1), p.79-87

1998

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Development, validation, and interlaboratory comparison of an HMG-CoA reductase inhibition assay for quantitation of atorvastatin in plasma matrices

Therapeutic drug monitoring, 1998-02, Vol.20 (1), p.41-49

1998

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Discovery of novel hepatoselective HMG-CoA reductase inhibitors for treating hypercholesterolemia: A bench-to-bedside case study on tissue selective drug distribution

Bioorganic & medicinal chemistry letters, 2011-05, Vol.21 (9), p.2725-2731

2011

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Discovery of pyrrole-based hepatoselective ligands as potent inhibitors of HMG-CoA reductase

Bioorganic & medicinal chemistry, 2007-08, Vol.15 (16), p.5576-5589

2007

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Design and synthesis of novel, conformationally restricted HMG-CoA reductase inhibitors

Bioorganic & medicinal chemistry letters, 2007-08, Vol.17 (16), p.4531-4537

2007

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Pyrazole inhibitors of HMG-CoA reductase: An attempt to dramatically reduce synthetic complexity through minimal analog re-design

Bioorganic & medicinal chemistry letters, 2007-10, Vol.17 (20), p.5567-5572

2007

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Attenuation of plasma low density lipoprotein cholesterol by select 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors in mice devoid of low density lipoprotein receptors

Journal of lipid research, 1997-12, Vol.38 (12), p.2502-2515

1997

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Pyrazole inhibitors of ΗΜΓ-CoA reductase : An attempt to dramatically reduce synthetic complexity through minimal analog re-design

Bioorganic & medicinal chemistry letters, 2007, Vol.17 (20), p.5567-5572

2007

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Expression of apolipoprotein[a] and plasminogen mRNAs in cynomolgus monkey liver and extrahepatic tissues

Journal of lipid research, 1996-09, Vol.37 (9), p.2029-2040

1996

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Retinoids Inhibit Primary Cynomolgus Monkey Hepatocyte Lipoprotein(a) Levels

Biochemical and biophysical research communications, 1997-09, Vol.238 (1), p.48-52

1997

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Increased urinary excretion of glycosphingolipids in familial hypercholesterolemia

Journal of lipid research, 1982-05, Vol.23 (4), p.513-522

1982

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Alterations in Cell Surface Glycosphingolipids and other Lipid Classes of Fibroblasts in Familial Hypercholesterolemia

Proceedings of the National Academy of Sciences - PNAS, 1976-12, Vol.73 (12), p.4339-4343

1976

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Effects of Tunicamycin on the Cell‐Surface Binding, Internalization and Degradation of Low‐Density Lipoproteins in Human Fibroblasts

European journal of biochemistry, 1981-12, Vol.120 (3), p.435-441

1981

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Hepatoselectivity of statins: Design and synthesis of 4-sulfamoyl pyrroles as HMG-CoA reductase inhibitors

Design and synthesis of hepatoselective, pyrrole-based HMG-CoA reductase inhibitors

CI-1011 lowers lipoprotein(a) and plasma cholesterol concentrations in chow-fed cynomolgus monkeys

Substituted Pyrazoles as Hepatoselective HMG-CoA Reductase Inhibitors: Discovery of (3R,5R)-7-[2-(4-Fluoro-phenyl)-4-isopropyl-5-(4-methyl-benzylcarbamoyl)-2H-pyrazol-3-yl]-3,5-dihydroxyheptanoic Acid (PF-3052334) as a Candidate for the Treatment of Hypercholesterolemia

Development, validation, and interlaboratory comparison of an HMG-CoA reductase inhibition assay for quantitation of atorvastatin in plasma matrices

Discovery of novel hepatoselective HMG-CoA reductase inhibitors for treating hypercholesterolemia: A bench-to-bedside case study on tissue selective drug distribution

Discovery of pyrrole-based hepatoselective ligands as potent inhibitors of HMG-CoA reductase

Design and synthesis of novel, conformationally restricted HMG-CoA reductase inhibitors

Pyrazole inhibitors of HMG-CoA reductase: An attempt to dramatically reduce synthetic complexity through minimal analog re-design

Attenuation of plasma low density lipoprotein cholesterol by select 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors in mice devoid of low density lipoprotein receptors

Pyrazole inhibitors of ΗΜΓ-CoA reductase : An attempt to dramatically reduce synthetic complexity through minimal analog re-design

Expression of apolipoprotein[a] and plasminogen mRNAs in cynomolgus monkey liver and extrahepatic tissues

Retinoids Inhibit Primary Cynomolgus Monkey Hepatocyte Lipoprotein(a) Levels

Increased urinary excretion of glycosphingolipids in familial hypercholesterolemia

Alterations in Cell Surface Glycosphingolipids and other Lipid Classes of Fibroblasts in Familial Hypercholesterolemia

Effects of Tunicamycin on the Cell‐Surface Binding, Internalization and Degradation of Low‐Density Lipoproteins in Human Fibroblasts

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