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1059 Spatial analysis of tumor infiltrating lymphocyte populations in syngeneic mouse tumor models after treatment with IL-12 (mWTX-330) and IL-2 (WTX-124) INDUKINETM molecules

Journal for immunotherapy of cancer, 2023-11, Vol.11 (Suppl 1), p.A1166-A1166

2023

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1058 Optimal antitumor immunity triggered by WTX-124, a clinical stage conditionally activated INDUKINETM molecule that releases fully potent IL-2 in the tumor microenvironment

Journal for immunotherapy of cancer, 2023-11, Vol.11 (Suppl 1), p.A1165-A1165

2023

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1074 PK/RO modeling of WTX-124, a tumor-activated IL-2 prodrug, highlights the potential for a substantially improved therapeutic index compared to other IL-2 molecules

Journal for immunotherapy of cancer, 2023-11, Vol.11 (Suppl 1), p.A1183-A1183

2023

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1075 Development of WTX-712, a conditionally active IL-21 INDUKINETM molecule for the treatment of cancer

Journal for immunotherapy of cancer, 2023-11, Vol.11 (Suppl 1), p.A1184-A1184

2023

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252 The combination of ACT and INDUKINE therapy leads to improved antitumor immunity in solid tumors

Journal for immunotherapy of cancer, 2023-11, Vol.11 (Suppl 1), p.A291-A291

2023

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The Discovery of Potent Antitumor Agent C11-Deoxypsymberin/irciniastatin A: Total Synthesis and Biology of Advanced Psymberin Analogs

Organic letters, 2009-02, Vol.11 (4), p.867-870

2009

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Characterization of ASP8374, a fully-human, antagonistic anti-TIGIT monoclonal antibody

Cancer treatment and research communications, 2021, Vol.28, p.100433-100433, Article 100433

2021

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Human Semaphorin K1 Is Glycosylphosphatidylinositol-linked and Defines a New Subfamily of Viral-related Semaphorins

The Journal of biological chemistry, 1998-08, Vol.273 (35), p.22428-22434

1998

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Abstract 1723: WTX-124 is an IL-2 pro-drug conditionally activated in tumors and able to induce complete regressions in mouse tumor models

Cancer research (Chicago, Ill.), 2021-07, Vol.81 (13_Supplement), p.1723-1723

2021

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Abstract 2727: The discovery and characterization of PTZ-201, a fully-human, high affinity, antagonistic anti-TIGIT monoclonal antibody

Cancer research (Chicago, Ill.), 2018-07, Vol.78 (13_Supplement), p.2727-2727

2018

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SCH529074, a Small Molecule Activator of Mutant p53, Which Binds p53 DNA Binding Domain (DBD), Restores Growth-suppressive Function to Mutant p53 and Interrupts HDM2-mediated Ubiquitination of Wild Type p53

The Journal of biological chemistry, 2010-04, Vol.285 (14), p.10198-10212

2010

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Discovery of a Conditionally Activated IL-2 that Promotes Antitumor Immunity and Induces Tumor Regression

Cancer immunology research, 2022-05, Vol.10 (5), p.581-596

2022

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mWTX-330, an IL-12 INDUKINE Molecule, Activates and Reshapes Tumor-Infiltrating CD8+ T and NK Cells to Generate Antitumor Immunity

Cancer immunology research, 2023-07, Vol.11 (7), p.962-977

2023

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Abstract 1829: Generation of IL-21 INDUKINETM molecules for the treatment of cancer

Cancer research (Chicago, Ill.), 2023-04, Vol.83 (7_Supplement), p.1829-1829

2023

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Abstract 1817: WTX-613, (JZP898) a selectively activated IFNα INDUKINE™ molecule, reprograms the tumor microenvironment and generates robust anti-tumor immunity as a monotherapy and in combination with checkpoint inhibitors

Cancer research (Chicago, Ill.), 2023-04, Vol.83 (7_Supplement), p.1817-1817

2023

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Abstract 2054: WTX-124 is a novel IL-2 pro-drug that is conditionally activated in tumors and drives anti-tumor immunity by activating tumor infiltrating CD8+ T cells

Cancer research (Chicago, Ill.), 2022-06, Vol.82 (12_Supplement), p.2054-2054

2022

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Evaluating TBK1 as a therapeutic target in cancers with activated IRF3

Molecular cancer research, 2014-07, Vol.12 (7), p.1055-1066

2014

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Abstract 2055: WTX-330 is a conditionally activated IL-12 prodrug that fundamentally reprograms tumor infiltrating CD8+ T cells and drives tumor regression

Cancer research (Chicago, Ill.), 2022-06, Vol.82 (12_Supplement), p.2055-2055

2022

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Detection of Src homology 3-binding proteins, including paxillin, in normal and v-Src-transformed Balb/c 3T3 cells

The Journal of biological chemistry, 1993-07, Vol.268 (20), p.14956-14963

1993

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Identification of Src, Fyn, and Lyn SH3-binding proteins: implications for a function of SH3 domains

Molecular and Cellular Biology, 1994-07, Vol.14 (7), p.4509-4521

1994

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Solution Structure of the SH3 Domain of Src and Identification of its Ligand-Binding Site

Science (American Association for the Advancement of Science), 1992-12, Vol.258 (5088), p.1665-1668

1992

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Synthesis of seco-psymberin/irciniastatin A: the discovery of a novel PhI(OAc) 2 mediated cascade cyclization reaction

Tetrahedron letters, 2008-05, Vol.49 (22), p.3592-3595

2008

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Effects of SH2 and SH3 deletions on the functional activities of wild-type and transforming variants of c-Src

Molecular and Cellular Biology, 1992-04, Vol.12 (4), p.1835-1845

1992

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Discovery of Novel 3,3-Disubstituted Piperidines as Orally Bioavailable, Potent, and Efficacious HDM2-p53 Inhibitors

ACS medicinal chemistry letters, 2016-03, Vol.7 (3), p.324-329

2016

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ChemInform Abstract: New Applications of PhI(OAc)2 in Synthesis: Total Synthesis and SAR Development of Potent Antitumor Natural Product Psymberin/Irciniastatin A

ChemInform, 2010-01, Vol.41 (4), p.no-no

2010

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1059 Spatial analysis of tumor infiltrating lymphocyte populations in syngeneic mouse tumor models after treatment with IL-12 (mWTX-330) and IL-2 (WTX-124) INDUKINETM molecules

1058 Optimal antitumor immunity triggered by WTX-124, a clinical stage conditionally activated INDUKINETM molecule that releases fully potent IL-2 in the tumor microenvironment

1074 PK/RO modeling of WTX-124, a tumor-activated IL-2 prodrug, highlights the potential for a substantially improved therapeutic index compared to other IL-2 molecules

1075 Development of WTX-712, a conditionally active IL-21 INDUKINETM molecule for the treatment of cancer

252 The combination of ACT and INDUKINE therapy leads to improved antitumor immunity in solid tumors

The Discovery of Potent Antitumor Agent C11-Deoxypsymberin/irciniastatin A: Total Synthesis and Biology of Advanced Psymberin Analogs

Characterization of ASP8374, a fully-human, antagonistic anti-TIGIT monoclonal antibody

Human Semaphorin K1 Is Glycosylphosphatidylinositol-linked and Defines a New Subfamily of Viral-related Semaphorins

Abstract 1723: WTX-124 is an IL-2 pro-drug conditionally activated in tumors and able to induce complete regressions in mouse tumor models

Abstract 2727: The discovery and characterization of PTZ-201, a fully-human, high affinity, antagonistic anti-TIGIT monoclonal antibody

SCH529074, a Small Molecule Activator of Mutant p53, Which Binds p53 DNA Binding Domain (DBD), Restores Growth-suppressive Function to Mutant p53 and Interrupts HDM2-mediated Ubiquitination of Wild Type p53

Discovery of a Conditionally Activated IL-2 that Promotes Antitumor Immunity and Induces Tumor Regression

mWTX-330, an IL-12 INDUKINE Molecule, Activates and Reshapes Tumor-Infiltrating CD8+ T and NK Cells to Generate Antitumor Immunity

Abstract 1829: Generation of IL-21 INDUKINETM molecules for the treatment of cancer

Abstract 1817: WTX-613, (JZP898) a selectively activated IFNα INDUKINE™ molecule, reprograms the tumor microenvironment and generates robust anti-tumor immunity as a monotherapy and in combination with checkpoint inhibitors

Abstract 2054: WTX-124 is a novel IL-2 pro-drug that is conditionally activated in tumors and drives anti-tumor immunity by activating tumor infiltrating CD8+ T cells

Evaluating TBK1 as a therapeutic target in cancers with activated IRF3

Abstract 2055: WTX-330 is a conditionally activated IL-12 prodrug that fundamentally reprograms tumor infiltrating CD8+ T cells and drives tumor regression

Detection of Src homology 3-binding proteins, including paxillin, in normal and v-Src-transformed Balb/c 3T3 cells

Identification of Src, Fyn, and Lyn SH3-binding proteins: implications for a function of SH3 domains

Solution Structure of the SH3 Domain of Src and Identification of its Ligand-Binding Site

Synthesis of seco-psymberin/irciniastatin A: the discovery of a novel PhI(OAc) 2 mediated cascade cyclization reaction

Effects of SH2 and SH3 deletions on the functional activities of wild-type and transforming variants of c-Src

Discovery of Novel 3,3-Disubstituted Piperidines as Orally Bioavailable, Potent, and Efficacious HDM2-p53 Inhibitors

ChemInform Abstract: New Applications of PhI(OAc)2 in Synthesis: Total Synthesis and SAR Development of Potent Antitumor Natural Product Psymberin/Irciniastatin A

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