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The biology and therapeutic targeting of the proprotein convertases

Nature reviews. Drug discovery, 2012-05, Vol.11 (5), p.367-383

2012

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The PCSK9 discovery, an inactive protease with varied functions in hypercholesterolemia, viral infections, and cancer

Journal of lipid research, 2021-01, Vol.62, p.100130-100130, Article 100130

Seidah, Nabil G.

2021

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Proprotein convertase subtilisin/kexin type 9 (PCSK9) can mediate degradation of the low density lipoprotein receptor-related protein 1 (LRP-1)

PloS one, 2013-05, Vol.8 (5), p.e64145-e64145

2013

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New developments in proprotein convertase subtilisin-kexin 9's biology and clinical implications

Current opinion in lipidology, 2016-06, Vol.27 (3), p.274-281

Seidah, Nabil G

2016

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Proprotein convertase subtilisin kexin 9 (PCSK9) inhibitors in the treatment of hypercholesterolemia and other pathologies

Current pharmaceutical design, 2013-05, Vol.19 (17), p.3161

Seidah, Nabil G

2013

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The Proprotein Convertases in Hypercholesterolemia and Cardiovascular Diseases: Emphasis on Proprotein Convertase Subtilisin/Kexin 9

Pharmacological reviews, 2017-01, Vol.69 (1), p.33-52

2017

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What lies ahead for the proprotein convertases?

Annals of the New York Academy of Sciences, 2011-03, Vol.1220 (1), p.149-161

Seidah, Nabil G.

2011

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Transcriptome Analysis Reveals Nonfoamy Rather Than Foamy Plaque Macrophages Are Proinflammatory in Atherosclerotic Murine Models

Circulation research, 2018-10, Vol.123 (10), p.1127-1142

2018

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Lipoprotein(a) Catabolism Is Regulated by Proprotein Convertase Subtilisin/Kexin Type 9 through the Low Density Lipoprotein Receptor

The Journal of biological chemistry, 2015-05, Vol.290 (18), p.11649-11662

2015

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Gene Inactivation of Proprotein Convertase Subtilisin/Kexin Type 9 Reduces Atherosclerosis in Mice

Circulation (New York, N.Y.), 2012-02, Vol.125 (7), p.894-901

2012

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Annexin A2 is a natural extrahepatic inhibitor of the PCSK9-induced LDL receptor degradation

PloS one, 2012-07, Vol.7 (7), p.e41865-e41865

2012

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Processing of Human Toll-like Receptor 7 by Furin-like Proprotein Convertases Is Required for Its Accumulation and Activity in Endosomes

Immunity (Cambridge, Mass.), 2013-10, Vol.39 (4), p.711-721

2013

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How Do Enveloped Viruses Exploit the Secretory Proprotein Convertases to Regulate Infectivity and Spread?

Viruses, 2021-06, Vol.13 (7), p.1229

2021

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Cleavage of a Neuroinvasive Human Respiratory Virus Spike Glycoprotein by Proprotein Convertases Modulates Neurovirulence and Virus Spread within the Central Nervous System

PLoS pathogens, 2015-11, Vol.11 (11), p.e1005261-e1005261

2015

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PCSK9 as a therapeutic target of dyslipidemia

Expert opinion on therapeutic targets, 2009-01, Vol.13 (1), p.19-28

Seidah, Nabil G

2009

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PCSK9 inhibition-mediated reduction in Lp(a) with evolocumab: an analysis of 10 clinical trials and the LDL receptor's role[S]

Journal of lipid research, 2016-06, Vol.57 (6), p.1086-1096

2016

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Caffeine blocks SREBP2-induced hepatic PCSK9 expression to enhance LDLR-mediated cholesterol clearance

Nature communications, 2022-02, Vol.13 (1), p.770-770, Article 770

2022

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Annexin A2 Is a C-terminal PCSK9-binding Protein That Regulates Endogenous Low Density Lipoprotein Receptor Levels

The Journal of biological chemistry, 2008-11, Vol.283 (46), p.31791-31801

2008

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New insights of altered lipid profile in Fragile X Syndrome

PloS one, 2017-03, Vol.12 (3), p.e0174301-e0174301

2017

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Circulating proprotein convertase subtilisin/kexin 9 (PCSK9) regulates VLDLR protein and triglyceride accumulation in visceral adipose tissue

Arteriosclerosis, thrombosis, and vascular biology, 2011-04, Vol.31 (4), p.785

2011

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Chloroquine is a potent inhibitor of SARS coronavirus infection and spread

Virology journal, 2005-08, Vol.2 (1), p.69-69, Article 69

2005

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Implication of the proprotein convertases in iron homeostasis: Proprotein convertase 7 sheds human transferrin receptor 1 and furin activates hepcidin

Hepatology (Baltimore, Md.), 2013-06, Vol.57 (6), p.2514-2524

2013

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Proprotein convertase subtilisin/kexin type 9 (PCSK9): Hepatocyte‐specific low‐density lipoprotein receptor degradation and critical role in mouse liver regeneration

Hepatology (Baltimore, Md.), 2008-08, Vol.48 (2), p.646-654

2008

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A locked nucleic acid antisense oligonucleotide (LNA) silences PCSK9 and enhances LDLR expression in vitro and in vivo

PloS one, 2010-05, Vol.5 (5), p.e10682

2010

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The Proprotein Convertase PCSK9 Induces the Degradation of Low Density Lipoprotein Receptor (LDLR) and Its Closest Family Members VLDLR and ApoER2

The Journal of biological chemistry, 2008-01, Vol.283 (4), p.2363-2372

2008

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The biology and therapeutic targeting of the proprotein convertases

The PCSK9 discovery, an inactive protease with varied functions in hypercholesterolemia, viral infections, and cancer

Proprotein convertase subtilisin/kexin type 9 (PCSK9) can mediate degradation of the low density lipoprotein receptor-related protein 1 (LRP-1)

New developments in proprotein convertase subtilisin-kexin 9's biology and clinical implications

Proprotein convertase subtilisin kexin 9 (PCSK9) inhibitors in the treatment of hypercholesterolemia and other pathologies

The Proprotein Convertases in Hypercholesterolemia and Cardiovascular Diseases: Emphasis on Proprotein Convertase Subtilisin/Kexin 9

What lies ahead for the proprotein convertases?

Transcriptome Analysis Reveals Nonfoamy Rather Than Foamy Plaque Macrophages Are Proinflammatory in Atherosclerotic Murine Models

Lipoprotein(a) Catabolism Is Regulated by Proprotein Convertase Subtilisin/Kexin Type 9 through the Low Density Lipoprotein Receptor

Gene Inactivation of Proprotein Convertase Subtilisin/Kexin Type 9 Reduces Atherosclerosis in Mice

Annexin A2 is a natural extrahepatic inhibitor of the PCSK9-induced LDL receptor degradation

Processing of Human Toll-like Receptor 7 by Furin-like Proprotein Convertases Is Required for Its Accumulation and Activity in Endosomes

How Do Enveloped Viruses Exploit the Secretory Proprotein Convertases to Regulate Infectivity and Spread?

Cleavage of a Neuroinvasive Human Respiratory Virus Spike Glycoprotein by Proprotein Convertases Modulates Neurovirulence and Virus Spread within the Central Nervous System

PCSK9 as a therapeutic target of dyslipidemia

PCSK9 inhibition-mediated reduction in Lp(a) with evolocumab: an analysis of 10 clinical trials and the LDL receptor's role[S]

Caffeine blocks SREBP2-induced hepatic PCSK9 expression to enhance LDLR-mediated cholesterol clearance

Annexin A2 Is a C-terminal PCSK9-binding Protein That Regulates Endogenous Low Density Lipoprotein Receptor Levels

New insights of altered lipid profile in Fragile X Syndrome

Circulating proprotein convertase subtilisin/kexin 9 (PCSK9) regulates VLDLR protein and triglyceride accumulation in visceral adipose tissue

Chloroquine is a potent inhibitor of SARS coronavirus infection and spread

Implication of the proprotein convertases in iron homeostasis: Proprotein convertase 7 sheds human transferrin receptor 1 and furin activates hepcidin

Proprotein convertase subtilisin/kexin type 9 (PCSK9): Hepatocyte‐specific low‐density lipoprotein receptor degradation and critical role in mouse liver regeneration

A locked nucleic acid antisense oligonucleotide (LNA) silences PCSK9 and enhances LDLR expression in vitro and in vivo

The Proprotein Convertase PCSK9 Induces the Degradation of Low Density Lipoprotein Receptor (LDLR) and Its Closest Family Members VLDLR and ApoER2

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