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Statins upregulate PCSK9, the gene encoding the proprotein convertase neural apoptosis-regulated convertase-1 implicated in familial hypercholesterolemia

Arteriosclerosis, thrombosis, and vascular biology, 2004-08, Vol.24 (8), p.1454-1459

2004

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Proprotein Convertase Subtilisin/Kexin Type 9 Deficiency Reduces Melanoma Metastasis in Liver

Neoplasia (New York, N.Y.), 2012-12, Vol.14 (12), p.1122-IN5

2012

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Proprotein and prohormone convertases: a family of subtilases generating diverse bioactive polypeptides

Brain research, 1999-11, Vol.848 (1-2), p.45-62

1999

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The Secretory Proprotein Convertase Neural Apoptosis-Regulated Convertase 1 (NARC-1): Liver Regeneration and Neuronal Differentiation

Proceedings of the National Academy of Sciences - PNAS, 2003-02, Vol.100 (3), p.928-933

2003

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Mutations in PCSK9 cause autosomal dominant hypercholesterolemia

Nature genetics, 2003-06, Vol.34 (2), p.154-156

2003

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NARC-1/PCSK9 and its natural mutants: zymogen cleavage and effects on the low density lipoprotein (LDL) receptor and LDL cholesterol

The Journal of biological chemistry, 2004-11, Vol.279 (47), p.48865-48875

2004

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Endothelium-restricted overexpression of human endothelin-1 causes vascular remodeling and endothelial dysfunction

Circulation (New York, N.Y.), 2004-10, Vol.110 (15), p.2233-2240

2004

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Quantitative peptidomics of mice lacking peptide-processing enzymes

Methods in molecular biology (Clifton, N.J.), 2011, Vol.768, p.307

2011

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The Lassa Virus Glycoprotein Precursor GP-C is Proteolytically Processed by Subtilase SKI-1/S1P

Proceedings of the National Academy of Sciences - PNAS, 2001-10, Vol.98 (22), p.12701-12705

2001

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Insights from bacterial subtilases into the mechanisms of intramolecular chaperone-mediated activation of furin

Methods in molecular biology (Clifton, N.J.), 2011, Vol.768, p.59

2011

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The proprotein convertases, 20 years later

Methods in molecular biology (Clifton, N.J.), 2011, Vol.768, p.23

Seidah, Nabil G

2011

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Biosynthesis and Post-translational Processing of the Precursor to Brain-derived Neurotrophic Factor

The Journal of biological chemistry, 2001-04, Vol.276 (16), p.12660-12666

2001

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A Serine Protease Inhibitor Prevents Endoplasmic Reticulum Stress-induced Cleavage but Not Transport of the Membrane-bound Transcription Factor ATF6

The Journal of biological chemistry, 2003-08, Vol.278 (33), p.31024-31032

2003

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Coordinated Expression of β‐Amyloid Precursor Protein and the Putative β‐Secretase BACE and α‐Secretase ADAM10 in Mouse and Human Brain

Journal of neurochemistry, 2000-11, Vol.75 (5), p.2133-2143

2000

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The Notch1 Receptor is Cleaved Constitutively by a Furin-Like Convertase

Proceedings of the National Academy of Sciences - PNAS, 1998-07, Vol.95 (14), p.8108-8112

1998

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Dual regulation of the LDL receptor—Some clarity and new questions

Cell metabolism, 2005-05, Vol.1 (5), p.290-292

2005

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The secretory proprotein convertases furin, PC5, and PC7 activate VEGF-C to induce tumorigenesis

The Journal of clinical investigation, 2003-06, Vol.111 (11), p.1723-1732

2003

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Neuroendocrine secretory protein 7B2: structure, expression and functions

Biochemical journal, 2001-07, Vol.357 (Pt 2), p.329-342

2001

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Eukaryotic protein processing: endoproteolysis of precursor proteins

Current opinion in biotechnology, 1997-10, Vol.8 (5), p.602-607

1997

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Proprotein Covertases Are Responsible for Proteolysis and Inactivation of Endothelial Lipase

The Journal of biological chemistry, 2005-11, Vol.280 (44), p.36551-36559

2005

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Precursor convertases in the secretory pathway, cytosol and extracellular milieu

Essays in biochemistry, 2002-01, Vol.38, p.79-94

2002

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Dysregulation of dynorphins in Alzheimer disease

Neurobiology of aging, 2007-11, Vol.28 (11), p.1700-1708

2007

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Opposite Roles of Furin and PC5A in N-Cadherin Processing

Neoplasia (New York, N.Y.), 2012-10, Vol.14 (10), p.880-IN3

2012

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Proprotein Convertases in Tumor Progression and Malignancy : Novel Targets in Cancer Therapy

The American journal of pathology, 2002-06, Vol.160 (6), p.1921-1935

2002

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Post-translational processing of beta-secretase (beta-amyloid-converting enzyme) and its ectodomain shedding. The pro- and transmembrane/cytosolic domains affect its cellular activity and amyloid-beta production

The Journal of biological chemistry, 2001-04, Vol.276 (14), p.10879-10887

2001

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Statins upregulate PCSK9, the gene encoding the proprotein convertase neural apoptosis-regulated convertase-1 implicated in familial hypercholesterolemia

Proprotein Convertase Subtilisin/Kexin Type 9 Deficiency Reduces Melanoma Metastasis in Liver

Proprotein and prohormone convertases: a family of subtilases generating diverse bioactive polypeptides

The Secretory Proprotein Convertase Neural Apoptosis-Regulated Convertase 1 (NARC-1): Liver Regeneration and Neuronal Differentiation

Mutations in PCSK9 cause autosomal dominant hypercholesterolemia

NARC-1/PCSK9 and its natural mutants: zymogen cleavage and effects on the low density lipoprotein (LDL) receptor and LDL cholesterol

Endothelium-restricted overexpression of human endothelin-1 causes vascular remodeling and endothelial dysfunction

Quantitative peptidomics of mice lacking peptide-processing enzymes

The Lassa Virus Glycoprotein Precursor GP-C is Proteolytically Processed by Subtilase SKI-1/S1P

Insights from bacterial subtilases into the mechanisms of intramolecular chaperone-mediated activation of furin

The proprotein convertases, 20 years later

Biosynthesis and Post-translational Processing of the Precursor to Brain-derived Neurotrophic Factor

A Serine Protease Inhibitor Prevents Endoplasmic Reticulum Stress-induced Cleavage but Not Transport of the Membrane-bound Transcription Factor ATF6

Coordinated Expression of β‐Amyloid Precursor Protein and the Putative β‐Secretase BACE and α‐Secretase ADAM10 in Mouse and Human Brain

The Notch1 Receptor is Cleaved Constitutively by a Furin-Like Convertase

Dual regulation of the LDL receptor—Some clarity and new questions

The secretory proprotein convertases furin, PC5, and PC7 activate VEGF-C to induce tumorigenesis

Neuroendocrine secretory protein 7B2: structure, expression and functions

Eukaryotic protein processing: endoproteolysis of precursor proteins

Proprotein Covertases Are Responsible for Proteolysis and Inactivation of Endothelial Lipase

Precursor convertases in the secretory pathway, cytosol and extracellular milieu

Dysregulation of dynorphins in Alzheimer disease

Opposite Roles of Furin and PC5A in N-Cadherin Processing

Proprotein Convertases in Tumor Progression and Malignancy : Novel Targets in Cancer Therapy

Post-translational processing of beta-secretase (beta-amyloid-converting enzyme) and its ectodomain shedding. The pro- and transmembrane/cytosolic domains affect its cellular activity and amyloid-beta production

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