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Small-molecule targeting of proliferating cell nuclear antigen chromatin association inhibits tumor cell growth

Molecular pharmacology, 2012-06, Vol.81 (6), p.811-819

2012

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Ciprofloxacin is an inhibitor of the Mcm2-7 replicative helicase

Bioscience reports, 2013-10, Vol.33 (5), p.e00072

2013

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Chaetocin-mediated SUV39H1 inhibition targets stemness and oncogenic networks of diffuse midline gliomas and synergizes with ONC201

Neuro-oncology (Charlottesville, Va.), 2024-04, Vol.26 (4), p.735-748

2024

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New substituted 4H-chromenes as anticancer agents

Bioorganic & medicinal chemistry letters, 2012-07, Vol.22 (13), p.4458-4461

2012

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Identification of imidazoquinoline derivatives as potent antiglioma agents

Medicinal chemistry (Shp-sariqah, United Arab Emirates), 2015-01, Vol.11 (4), p.400

2015

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Combined Rational Design and a High Throughput Screening Platform for Identifying Chemical Inhibitors of a Ras-activating Enzyme

The Journal of biological chemistry, 2015-05, Vol.290 (20), p.12879-12898

2015

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Identification of Akt-selective cytotoxic compounds that enhance cytotoxic responses to rapamycin

Cancer biology & therapy, 2010-12, Vol.10 (12), p.1256-1261

2010

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Rational Design of Small Molecule Inhibitors Targeting the Ras GEF, SOS1

Chemistry & biology, 2014-12, Vol.21 (12), p.1618-1628

2014

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A novel, soluble compound, C25, sensitizes to TRAIL-induced apoptosis through upregulation of DR5 expression

Anti-cancer drugs, 2015-06, Vol.26 (5), p.518-530

2015

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Extending matrix-assisted laser desorption/ionization triple quadrupole mass spectrometry enzyme screening assays to targets with small molecule substrates

Rapid communications in mass spectrometry, 2009-10, Vol.23 (20), p.3293-3300

2009

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Target validation and structure–activity analysis of a series of novel PCNA inhibitors

Pharmacology research & perspectives, 2015-03, Vol.3 (2), p.e00115-n/a

2015

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Development of a small-molecule screening method for inhibitors of cellular response to myostatin and activin A

Journal of biomolecular screening, 2013-08, Vol.18 (7), p.837-844

2013

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Multiplex Enzyme Assays and Inhibitor Screening by Mass Spectrometry

Journal of biomolecular screening, 2010-09, Vol.15 (8), p.1001-1007

2010

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Serendipitous discovery of novel bacterial methionine aminopeptidase inhibitors

Proteins, structure, function, and bioinformatics, 2007-02, Vol.66 (3), p.538-546

2007

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Discovery of (3S)-Amino-(4R)-ethylpiperidinyl Quinolones as Potent Antibacterial Agents with a Broad Spectrum of Activity and Activity against Resistant Pathogens

Journal of medicinal chemistry, 2003-08, Vol.46 (17), p.3655-3661

2003

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Applications of solid supported azide anion: a one-pot, two-step preparation of functionalized 1,2,3-triazoles

Tetrahedron letters, 2003-03, Vol.44 (10), p.2153-2155

2003

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A simple method for the preparation and selective functionalization of 4,5-diaminopyrazoles

Tetrahedron letters, 2003-03, Vol.44 (14), p.3009-3011

2003

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Inhibition of UBE2N As a Therapeutic Approach in Myelodysplastic Syndromes (MDS) and Acute Myeloid Leukemia (AML)

Blood, 2016-12, Vol.128 (22), p.579-579

2016

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Scale-up and Validation of a MALDI-MS-based Inhibitor Screening Technology

Journal of biomolecular techniques, 2013-05, Vol.24 (Suppl), p.S51-S52

2013

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Hydroxylamines and sulfinamide as amine components in the Petasis boronic acid–Mannich reaction: synthesis of N-hydroxy or alkoxy-α-aminocarboxylicacids and N-( tert-butyl sulfinyl)-α-amino carboxylicacids

Tetrahedron letters, 2003-12, Vol.44 (49), p.8865-8868

2003

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The synthesis of aza-β-lactams via tandem Petasis–Ugi multi-component condensation and 1,3-diisopropylcarbodiimide (DIC) condensation reaction

Tetrahedron letters, 2003-08, Vol.44 (33), p.6297-6300

2003

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Novel Petasis boronic acid reactions with 1,3,5-tri-oxygenated benzenes

Tetrahedron letters, 2003-12, Vol.44 (49), p.8861-8863

2003

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Novel Petasis boronic acid–Mannich reactions with tertiary aromatic amines

Tetrahedron letters, 2003-07, Vol.44 (31), p.5819-5821

2003

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Small-molecule targeting of proliferating cell nuclear antigen chromatin association inhibits tumor cell growth

Ciprofloxacin is an inhibitor of the Mcm2-7 replicative helicase

Chaetocin-mediated SUV39H1 inhibition targets stemness and oncogenic networks of diffuse midline gliomas and synergizes with ONC201

New substituted 4H-chromenes as anticancer agents

Identification of imidazoquinoline derivatives as potent antiglioma agents

Combined Rational Design and a High Throughput Screening Platform for Identifying Chemical Inhibitors of a Ras-activating Enzyme

Small-molecule-induced epigenetic rejuvenation promotes SREBP condensation and overcomes barriers to CNS myelin regeneration

Blocking UBE2N abrogates oncogenic immune signaling in acute myeloid leukemia

Identification of Akt-selective cytotoxic compounds that enhance cytotoxic responses to rapamycin

Rational Design of Small Molecule Inhibitors Targeting the Ras GEF, SOS1

A novel, soluble compound, C25, sensitizes to TRAIL-induced apoptosis through upregulation of DR5 expression

Extending matrix-assisted laser desorption/ionization triple quadrupole mass spectrometry enzyme screening assays to targets with small molecule substrates

Target validation and structure–activity analysis of a series of novel PCNA inhibitors

Development of a small-molecule screening method for inhibitors of cellular response to myostatin and activin A

Multiplex Enzyme Assays and Inhibitor Screening by Mass Spectrometry

Serendipitous discovery of novel bacterial methionine aminopeptidase inhibitors

Discovery of (3S)-Amino-(4R)-ethylpiperidinyl Quinolones as Potent Antibacterial Agents with a Broad Spectrum of Activity and Activity against Resistant Pathogens

Applications of solid supported azide anion: a one-pot, two-step preparation of functionalized 1,2,3-triazoles

A simple method for the preparation and selective functionalization of 4,5-diaminopyrazoles

Inhibition of UBE2N As a Therapeutic Approach in Myelodysplastic Syndromes (MDS) and Acute Myeloid Leukemia (AML)

Scale-up and Validation of a MALDI-MS-based Inhibitor Screening Technology

Hydroxylamines and sulfinamide as amine components in the Petasis boronic acid–Mannich reaction: synthesis of N-hydroxy or alkoxy-α-aminocarboxylicacids and N-( tert-butyl sulfinyl)-α-amino carboxylicacids

The synthesis of aza-β-lactams via tandem Petasis–Ugi multi-component condensation and 1,3-diisopropylcarbodiimide (DIC) condensation reaction

Novel Petasis boronic acid reactions with 1,3,5-tri-oxygenated benzenes

Novel Petasis boronic acid–Mannich reactions with tertiary aromatic amines

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