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Functional Characterization of Melanocortin-4 Receptor Mutations Associated with Childhood Obesity

Endocrinology (Philadelphia), 2003-10, Vol.144 (10), p.4544-4551

2003

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Functional Analyses of Melanocortin-4 Receptor Mutations Identified from Patients with Binge Eating Disorder and Nonobese or Obese Subjects

The journal of clinical endocrinology and metabolism, 2005-10, Vol.90 (10), p.5632-5638

2005

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Functional Characterization of Melanocortin-3 Receptor Variants Identify a Loss-of-Function Mutation Involving an Amino Acid Critical for G Protein-Coupled Receptor Activation

The journal of clinical endocrinology and metabolism, 2004-08, Vol.89 (8), p.3936-3942

2004

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Constitutive and Agonist-dependent Self-association of the Cell Surface Human Lutropin Receptor

The Journal of biological chemistry, 2004-02, Vol.279 (7), p.5904-5914

2004

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The lutropin/choriogonadotropin receptor ... 4 years later

Endocrine reviews, 1993-06, Vol.14 (3), p.324-347

Segaloff, D. L.

1993

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The Formation of a Salt Bridge Between Helices 3 and 6 Is Responsible for the Constitutive Activity and Lack of Hormone Responsiveness of the Naturally Occurring L457R Mutation of the Human Lutropin Receptor

The Journal of biological chemistry, 2005-07, Vol.280 (28), p.26169-26176

2005

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Naturally Occurring Mutations of the Luteinizing-Hormone Receptor: Lessons Learned about Reproductive Physiology and G Protein–Coupled Receptors

American journal of human genetics, 1999-10, Vol.65 (4), p.949-958

1999

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Expression and Localization of Luteinizing Hormone Receptor in the Female Mouse Reproductive Tract

Biology of reproduction, 2001-01, Vol.64 (1), p.179-187

2001

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Deletion of Codons 88–92 of the Melanocortin-4 Receptor Gene: A Novel Deleterious Mutation in an Obese Female

The journal of clinical endocrinology and metabolism, 2003-12, Vol.88 (12), p.5841-5845

2003

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Lutropin-Choriogonadotropin Receptor: An Unusual Member of the G Protein--Coupled Receptor Family

Science (American Association for the Advancement of Science), 1989-08, Vol.245 (4917), p.494-499

1989

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The testicular receptor for follicle stimulating hormone : structure and functional expression of cloned cDNA

Molecular endocrinology (Baltimore, Md.), 1990-04, Vol.4 (4), p.525-530

1990

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Chimeras of the Rat and Human FSH Receptors (FSHRs) Identify Residues that Permit or Suppress Transmembrane 6 Mutation-Induced Constitutive Activation of the FSHR via Rearrangements of Hydrophobic Interactions Between Helices 6 and 7

Molecular endocrinology (Baltimore, Md.), 2002-08, Vol.16 (8), p.1881-1892

2002

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A unique constitutively activating mutation in third transmembrane helix of luteinizing hormone receptor causes sporadic male gonadotropin-independent precocious puberty

The journal of clinical endocrinology and metabolism, 1998-07, Vol.83 (7), p.2435-2440

1998

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Extracellular domain of lutropin/choriogonadotropin receptor expressed in transfected cells binds choriogonadotropin with high affinity

The Journal of biological chemistry, 1990-12, Vol.265 (35), p.21411-21414

1990

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A homozygous microdeletion in helix 7 of the luteinizing hormone receptor associated with familial testicular and ovarian resistance is due to both decreased cell surface expression and impaired effector activation by the cell surface receptor

Molecular endocrinology (Baltimore, Md.), 1998-03, Vol.12 (3), p.442-450

1998

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Constitutive activation of the LH receptor is associated with an alteration in the conformation of the ectodomain

Molecular and cellular endocrinology, 2002-08, Vol.194 (1), p.211-215

2002

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Constitutive activation of G protein-coupled receptors as a result of selective substitution of a conserved leucine residue in transmembrane helix III

Molecular endocrinology (Baltimore, Md.), 2000-08, Vol.14 (8), p.1272-1282

2000

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The six N-linked carbohydrates of the lutropin/choriogonadotropin receptor are not absolutely required for correct folding, cell surface expression, hormone binding, or signal transduction

Molecular endocrinology (Baltimore, Md.), 1997-05, Vol.11 (5), p.550-562

1997

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Desensitization of Gs-Coupled Receptor Signaling by Constitutively Active Mutants of the Human Lutropin/Choriogonadotropin Receptor

The journal of clinical endocrinology and metabolism, 2003-03, Vol.88 (3), p.1194-1204

2003

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A role for increased lutropin/choriogonadotropin receptor (LHR) gene transcription in the follitropin-stimulated induction of the LHR in granulosa cells

Molecular endocrinology (Baltimore, Md.), 1995-06, Vol.9 (6), p.734-744

1995

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Temperature sensitivity of some mutants of the lutropin/choriogonadotropin receptor

Endocrinology (Philadelphia), 1997, Vol.138 (1), p.85-91

1997

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Multiple elements and protein factors coordinate the basal and cyclic adenosine 3',5'-monophosphate-induced transcription of the lutropin receptor gene in rat granulosa cells

Endocrinology (Philadelphia), 1999-05, Vol.140 (5), p.2100

1999

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N-linked carbohydrates on G protein-coupled receptors: Mapping sites of attachment and determining functional roles

Methods in Enzymology, 2002, Vol.343, p.200-212

2002

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A novel cyclic adenosine 3',5'-monophosphate-responsive element involved in the transcriptional regulation of the lutropin receptor gene in granulosa cells

Molecular endocrinology (Baltimore, Md.), 2000-09, Vol.14 (9), p.1498-1508

2000

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Certain activating mutations within helix 6 of the human luteinizing hormone receptor may be explained by alterations that allow transmembrane regions to activate Gs

Molecular endocrinology (Baltimore, Md.), 1998-12, Vol.12 (12), p.1857

1998

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Functional Characterization of Melanocortin-4 Receptor Mutations Associated with Childhood Obesity

Functional Analyses of Melanocortin-4 Receptor Mutations Identified from Patients with Binge Eating Disorder and Nonobese or Obese Subjects

Functional Characterization of Melanocortin-3 Receptor Variants Identify a Loss-of-Function Mutation Involving an Amino Acid Critical for G Protein-Coupled Receptor Activation

Constitutive and Agonist-dependent Self-association of the Cell Surface Human Lutropin Receptor

The lutropin/choriogonadotropin receptor ... 4 years later

The Formation of a Salt Bridge Between Helices 3 and 6 Is Responsible for the Constitutive Activity and Lack of Hormone Responsiveness of the Naturally Occurring L457R Mutation of the Human Lutropin Receptor

Naturally Occurring Mutations of the Luteinizing-Hormone Receptor: Lessons Learned about Reproductive Physiology and G Protein–Coupled Receptors

Expression and Localization of Luteinizing Hormone Receptor in the Female Mouse Reproductive Tract

Deletion of Codons 88–92 of the Melanocortin-4 Receptor Gene: A Novel Deleterious Mutation in an Obese Female

Lutropin-Choriogonadotropin Receptor: An Unusual Member of the G Protein--Coupled Receptor Family

The testicular receptor for follicle stimulating hormone : structure and functional expression of cloned cDNA

Chimeras of the Rat and Human FSH Receptors (FSHRs) Identify Residues that Permit or Suppress Transmembrane 6 Mutation-Induced Constitutive Activation of the FSHR via Rearrangements of Hydrophobic Interactions Between Helices 6 and 7

A unique constitutively activating mutation in third transmembrane helix of luteinizing hormone receptor causes sporadic male gonadotropin-independent precocious puberty

Extracellular domain of lutropin/choriogonadotropin receptor expressed in transfected cells binds choriogonadotropin with high affinity

A homozygous microdeletion in helix 7 of the luteinizing hormone receptor associated with familial testicular and ovarian resistance is due to both decreased cell surface expression and impaired effector activation by the cell surface receptor

Constitutive activation of the LH receptor is associated with an alteration in the conformation of the ectodomain

Constitutive activation of G protein-coupled receptors as a result of selective substitution of a conserved leucine residue in transmembrane helix III

The six N-linked carbohydrates of the lutropin/choriogonadotropin receptor are not absolutely required for correct folding, cell surface expression, hormone binding, or signal transduction

Desensitization of Gs-Coupled Receptor Signaling by Constitutively Active Mutants of the Human Lutropin/Choriogonadotropin Receptor

A role for increased lutropin/choriogonadotropin receptor (LHR) gene transcription in the follitropin-stimulated induction of the LHR in granulosa cells

Temperature sensitivity of some mutants of the lutropin/choriogonadotropin receptor

Multiple elements and protein factors coordinate the basal and cyclic adenosine 3',5'-monophosphate-induced transcription of the lutropin receptor gene in rat granulosa cells

N-linked carbohydrates on G protein-coupled receptors: Mapping sites of attachment and determining functional roles

A novel cyclic adenosine 3',5'-monophosphate-responsive element involved in the transcriptional regulation of the lutropin receptor gene in granulosa cells

Certain activating mutations within helix 6 of the human luteinizing hormone receptor may be explained by alterations that allow transmembrane regions to activate Gs

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