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Catalytic Control in the EGF Receptor and Its Connection to General Kinase Regulatory Mechanisms

Molecular cell, 2011-04, Vol.42 (1), p.9-22

2011

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All the mutations that are fit to die

Cell chemical biology, 2024-02, Vol.31 (2), p.192-194

2024

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Protein Flexibility and Dissociation Pathway Differentiation Can Explain Onset of Resistance Mutations in Kinases

Angewandte Chemie (International ed.), 2022-07, Vol.61 (28), p.e202200983-n/a

International ed. in English, 2022

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Targeting Conformational Plasticity of Protein Kinases

ACS chemical biology, 2015-01, Vol.10 (1), p.190-200

2015

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Editorial overview: Molecular determinants, mechanisms, and state-of-the-art approaches in allostery

Current opinion in structural biology, 2024-06, Vol.86, p.102810-102810, Article 102810

2024

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Allo-targeting of the kinase domain: Insights from in silico studies and comparison with experiments

Current opinion in structural biology, 2024-02, Vol.84, p.102770-102770, Article 102770

2024

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Calculating Protein–Ligand Residence Times through State Predictive Information Bottleneck Based Enhanced Sampling

Journal of chemical theory and computation, 2024-07, Vol.20 (14), p.6341-6349

2024

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A dynamically coupled allosteric network underlies binding cooperativity in Src kinase

Nature communications, 2015-01, Vol.6 (1), p.5939-5939, Article 5939

2015

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Activation of tyrosine kinases by mutation of the gatekeeper threonine

Nature structural & molecular biology, 2008-10, Vol.15 (10), p.1109-1118

2008

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Probing conformational dynamics to understand kinase inhibition

eLife, 2023-10, Vol.12

2023

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Structural mechanism of a drug-binding process involving a large conformational change of the protein target

Nature communications, 2023-04, Vol.14 (1), p.1885-1885, Article 1885

2023

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How Does a Drug Molecule Find Its Target Binding Site?

Journal of the American Chemical Society, 2011-06, Vol.133 (24), p.9181-9183

2011

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Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones

Nature (London), 2014-07, Vol.511 (7507), p.94-98

2014

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A conserved mechanism of DEAD―box ATPase activation by nucleoporins and InsP6 in mRNA export

Nature (London), 2011-04, Vol.472 (7342), p.238-242

2011

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Survey of solution dynamics in Src kinase reveals allosteric cross talk between the ligand binding and regulatory sites

Nature communications, 2017-12, Vol.8 (1), p.2160-15, Article 2160

2017

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Inhibiting ACK1-mediated phosphorylation of C-terminal Src kinase counteracts prostate cancer immune checkpoint blockade resistance

Nature communications, 2022-11, Vol.13 (1), p.6929-6929, Article 6929

2022

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What Makes a Kinase Promiscuous for Inhibitors?

Cell chemical biology, 2019-03, Vol.26 (3), p.390-399.e5

2019

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Allosteric regulation and inhibition of protein kinases

Biochemical Society transactions, 2023-02, Vol.51 (1), p.373

2023

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conserved protonation-dependent switch controls drug binding in the Abl kinase

Proceedings of the National Academy of Sciences - PNAS, 2009-01, Vol.106 (1), p.139-144

2009

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Biochemical Studies of Systemic Lupus Erythematosus-Associated Mutations in Nonreceptor Tyrosine Kinases Ack1 and Brk

Biochemistry (Easton), 2023-03, Vol.62 (6), p.1124-1137

2023

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A Novel In Vitro CypD-Mediated p53 Aggregation Assay Suggests a Model for Mitochondrial Permeability Transition by Chaperone Systems

Journal of molecular biology, 2016-10, Vol.428 (20), p.4154-4167

2016

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Extended DNA-binding interfaces beyond the canonical SAP domain contribute to the function of replication stress regulator SDE2 at DNA replication forks

The Journal of biological chemistry, 2022-08, Vol.298 (8), p.102268-102268, Article 102268

2022

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Lucanthone, a Potential PPT1 Inhibitor, Perturbs Stemness, Reduces Tumor Microtube Formation, and Slows the Growth of Temozolomide-Resistant Gliomas In Vivo

The Journal of pharmacology and experimental therapeutics, 2024-03, Vol.389 (1), p.51

2024

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Mutation in Abl kinase with altered drug-binding kinetics indicates a novel mechanism of imatinib resistance

Proceedings of the National Academy of Sciences - PNAS, 2021-11, Vol.118 (46), p.1

2021

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Substrate-selective inhibitors that reprogram the activity of insulin-degrading enzyme

Nature chemical biology, 2019-06, Vol.15 (6), p.565

2019

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Catalytic Control in the EGF Receptor and Its Connection to General Kinase Regulatory Mechanisms

All the mutations that are fit to die

Protein Flexibility and Dissociation Pathway Differentiation Can Explain Onset of Resistance Mutations in Kinases

Targeting Conformational Plasticity of Protein Kinases

Editorial overview: Molecular determinants, mechanisms, and state-of-the-art approaches in allostery

Allo-targeting of the kinase domain: Insights from in silico studies and comparison with experiments

Calculating Protein–Ligand Residence Times through State Predictive Information Bottleneck Based Enhanced Sampling

A dynamically coupled allosteric network underlies binding cooperativity in Src kinase

Activation of tyrosine kinases by mutation of the gatekeeper threonine

Probing conformational dynamics to understand kinase inhibition

Structural mechanism of a drug-binding process involving a large conformational change of the protein target

How Does a Drug Molecule Find Its Target Binding Site?

Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones

A conserved mechanism of DEAD―box ATPase activation by nucleoporins and InsP6 in mRNA export

Survey of solution dynamics in Src kinase reveals allosteric cross talk between the ligand binding and regulatory sites

Inhibiting ACK1-mediated phosphorylation of C-terminal Src kinase counteracts prostate cancer immune checkpoint blockade resistance

What Makes a Kinase Promiscuous for Inhibitors?

Allosteric regulation and inhibition of protein kinases

conserved protonation-dependent switch controls drug binding in the Abl kinase

Biochemical Studies of Systemic Lupus Erythematosus-Associated Mutations in Nonreceptor Tyrosine Kinases Ack1 and Brk

A Novel In Vitro CypD-Mediated p53 Aggregation Assay Suggests a Model for Mitochondrial Permeability Transition by Chaperone Systems

Extended DNA-binding interfaces beyond the canonical SAP domain contribute to the function of replication stress regulator SDE2 at DNA replication forks

Lucanthone, a Potential PPT1 Inhibitor, Perturbs Stemness, Reduces Tumor Microtube Formation, and Slows the Growth of Temozolomide-Resistant Gliomas In Vivo

Mutation in Abl kinase with altered drug-binding kinetics indicates a novel mechanism of imatinib resistance

Substrate-selective inhibitors that reprogram the activity of insulin-degrading enzyme

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