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Catalytic Control in the EGF Receptor and Its Connection to General Kinase Regulatory Mechanisms

Molecular cell, 2011-04, Vol.42 (1), p.9-22

2011

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Targeting Conformational Plasticity of Protein Kinases

ACS chemical biology, 2015-01, Vol.10 (1), p.190-200

2015

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Structural mechanism of a drug-binding process involving a large conformational change of the protein target

Nature communications, 2023-04, Vol.14 (1), p.1885-1885, Article 1885

2023

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A dynamically coupled allosteric network underlies binding cooperativity in Src kinase

Nature communications, 2015-01, Vol.6 (1), p.5939-5939, Article 5939

2015

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Activation of tyrosine kinases by mutation of the gatekeeper threonine

Nature structural & molecular biology, 2008-10, Vol.15 (10), p.1109-1118

2008

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Probing conformational dynamics to understand kinase inhibition

eLife, 2023-10, Vol.12

2023

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Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones

Nature (London), 2014-07, Vol.511 (7507), p.94-98

2014

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Inhibiting ACK1-mediated phosphorylation of C-terminal Src kinase counteracts prostate cancer immune checkpoint blockade resistance

Nature communications, 2022-11, Vol.13 (1), p.6929-21, Article 6929

2022

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A conserved mechanism of DEAD-box ATPase activation by nucleoporins and InsP6 in mRNA export

Nature (London), 2011-04, Vol.472 (7342), p.238-242

2011

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Survey of solution dynamics in Src kinase reveals allosteric cross talk between the ligand binding and regulatory sites

Nature communications, 2017-12, Vol.8 (1), p.2160-15, Article 2160

2017

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conserved protonation-dependent switch controls drug binding in the Abl kinase

Proceedings of the National Academy of Sciences - PNAS, 2009-01, Vol.106 (1), p.139-144

2009

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Mechanism of CDK5/p25 Binding by CDK Inhibitors

Journal of medicinal chemistry, 2005-02, Vol.48 (3), p.671-679

2005

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Death by a thousand cuts through kinase inhibitor combinations that maximize selectivity and enable rational multitargeting

eLife, 2023-12, Vol.12

2023

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The C1q and gC1qR axis as a novel checkpoint inhibitor in cancer

Frontiers in immunology, 2024-04, Vol.15, p.1351656-1351656

2024

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A novel activating, germline JAK2 mutation, JAK2R564Q, causes familial essential thrombocytosis

Blood, 2014-02, Vol.123 (7), p.1059-1068

2014

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Multi-proxy analysis of relative sea-level and paleoshoreline changes during the last 2300 years in the Campi Flegrei caldera, Southern Italy

Quaternary international, 2021-11, Vol.602, p.110-130

2021

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Environmental changes related to the Holocene sea-level transgression and successive highstand (7–5.5 Kyr) at the NE coastal plain of Buenos Aires (Argentina)

Quaternary international, 2021-11, Vol.602, p.4-14

2021

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Late-Holocene evolution of the Northern Bay of Cádiz from geomorphological, stratigraphic and archaeological data

Quaternary international, 2021-11, Vol.602, p.92-109

2021

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Highly specific, bisubstrate-competitive Src inhibitors from DNA-templated macrocycles

Nature chemical biology, 2012-02, Vol.8 (4), p.366-374

2012

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Dynamically Coupled Residues within the SH2 Domain of FYN Are Key to Unlocking Its Activity

Structure (London), 2016-11, Vol.24 (11), p.1947-1959

2016

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High yield bacterial expression of active c‐Abl and c‐Src tyrosine kinases

Protein science, 2005-12, Vol.14 (12), p.3135-3139

2005

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All the mutations that are fit to die

Cell chemical biology, 2024-02, Vol.31 (2), p.192-194

2024

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Wetlands and lakes formation and evolution on the Lower Danube Floodplain during Middle and Late Holocene

Quaternary international, 2021-11, Vol.602, p.82-91

2021

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Holocene vegetation changes according to sea-level and climate dynamics on tidal flats of the Formoso River estuary, northeastern Brazil

Quaternary international, 2021-11, Vol.602, p.39-48

2021

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Using a multi-proxy approach to locate the elusive Phoenician/Persian anchorage of Tel Akko (Israel)

Quaternary international, 2021-11, Vol.602, p.66-81

2021

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Catalytic Control in the EGF Receptor and Its Connection to General Kinase Regulatory Mechanisms

Targeting Conformational Plasticity of Protein Kinases

Structural mechanism of a drug-binding process involving a large conformational change of the protein target

A dynamically coupled allosteric network underlies binding cooperativity in Src kinase

Activation of tyrosine kinases by mutation of the gatekeeper threonine

Probing conformational dynamics to understand kinase inhibition

Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones

Inhibiting ACK1-mediated phosphorylation of C-terminal Src kinase counteracts prostate cancer immune checkpoint blockade resistance

A conserved mechanism of DEAD-box ATPase activation by nucleoporins and InsP6 in mRNA export

Survey of solution dynamics in Src kinase reveals allosteric cross talk between the ligand binding and regulatory sites

conserved protonation-dependent switch controls drug binding in the Abl kinase

Mechanism of CDK5/p25 Binding by CDK Inhibitors

Death by a thousand cuts through kinase inhibitor combinations that maximize selectivity and enable rational multitargeting

The C1q and gC1qR axis as a novel checkpoint inhibitor in cancer

A novel activating, germline JAK2 mutation, JAK2R564Q, causes familial essential thrombocytosis

Multi-proxy analysis of relative sea-level and paleoshoreline changes during the last 2300 years in the Campi Flegrei caldera, Southern Italy

Environmental changes related to the Holocene sea-level transgression and successive highstand (7–5.5 Kyr) at the NE coastal plain of Buenos Aires (Argentina)

Late-Holocene evolution of the Northern Bay of Cádiz from geomorphological, stratigraphic and archaeological data

Highly specific, bisubstrate-competitive Src inhibitors from DNA-templated macrocycles

Dynamically Coupled Residues within the SH2 Domain of FYN Are Key to Unlocking Its Activity

High yield bacterial expression of active c‐Abl and c‐Src tyrosine kinases

All the mutations that are fit to die

Wetlands and lakes formation and evolution on the Lower Danube Floodplain during Middle and Late Holocene

Holocene vegetation changes according to sea-level and climate dynamics on tidal flats of the Formoso River estuary, northeastern Brazil

Using a multi-proxy approach to locate the elusive Phoenician/Persian anchorage of Tel Akko (Israel)

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