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Application of Crystallographic and Modeling Methods in the Design of Purine Nucleoside Phosphorylase Inhibitors

Proceedings of the National Academy of Sciences - PNAS, 1991-12, Vol.88 (24), p.11540-11544

1991

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Thiarabine, 1-(4-Thio-β-D-arabinofuranosyl)cytosine. A Deoxycytidine Analog With Excellent Anticancer Activity

Current medicinal chemistry, 2015-01, Vol.22 (34), p.3881-3896

2015

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Mechanism of inhibition of human immunodeficiency virus type 1 reverse transcriptase and human DNA polymerases alpha, beta, and gamma by the 5'-triphosphates of carbovir, 3'-azido-3'-deoxythymidine, 2',3'-dideoxyguanosine and 3'-deoxythymidine. A novel RNA template for the evaluation of antiretroviral drugs

The Journal of biological chemistry, 1991-01, Vol.266 (3), p.1754-1762

1991

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The Structural Basis for Substrate Specificity and Inhibition of Human S-Adenosylmethionine Decarboxylase

Biochemistry (Easton), 2001-08, Vol.40 (32), p.9484-9494

2001

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Programs to facilitate tuberculosis drug discovery: the tuberculosis antimicrobial acquisition and coordinating facility

Infectious disorders drug targets, 2007-06, Vol.7 (2), p.92-104

2007

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Phosphorylation of the enantiomers of the carbocyclic analog of 2'-deoxyguanosine in cells infected with herpes simplex virus type 1 and in uninfected cells. Lack of enantiomeric selectivity with the viral thymidine kinase

Molecular pharmacology, 1993-12, Vol.44 (6), p.1258-1266

1993

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Comparison of the Mechanism of Cytotoxicity of 2-Chloro-9-(2-deoxy-2-fluoro-Î²-d-arabinofuranosyl)adenine, 2-Chloro-9-(2-deoxy-2-fluoro-Î²-d-ribofuranosyl)adenine, and 2-Chloro-9-(2-deoxy-2,2-difluoro-Î²-d-ribofuranosyl)adenine in CEM Cells

Molecular pharmacology, 1999-03, Vol.55 (3), p.515-520

1999

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In vivo gene therapy of cancer with E. coli purine nucleoside phosphorylase

Human gene therapy, 1997-09, Vol.8 (14), p.1637-1644

1997

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Synthesis and biological activity of 2'-deoxy-4'-thio pyrimidine nucleosides

Journal of medicinal chemistry, 1991-08, Vol.34 (8), p.2361-2366

1991

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Structure−Activity Relationships of Bisphosphate Nucleotide Derivatives as P2Y1 Receptor Antagonists and Partial Agonists

Journal of medicinal chemistry, 1999-05, Vol.42 (9), p.1625-1638

1999

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Effects of 2-chloro-9-(3-deoxy-2-fluoro-β-D-arabinofuranosyl)adenine on K562 cellular metabolism and the inhibition of human ribonucleotide reductase and DNA polymerases by its 5'-triphosphate

Cancer research (Chicago, Ill.), 1991-05, Vol.51 (9), p.2386-2394

1991

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Metabolism of 4′-thio-β- d-arabinofuranosylcytosine in CEM cells

Biochemical pharmacology, 2000-12, Vol.60 (12), p.1925-1932

2000

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Incorporation of the carbocyclic analog of 2'-deoxyguanosine into the DNA of herpes simplex virus and of HEp-2 cells infected with herpes simplex virus

Molecular pharmacology, 1992-02, Vol.41 (2), p.245-251

1992

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Structure-based design of inhibitors of purine nucleoside phosphorylase. 1. 9-(Arylmethyl) derivatives of 9-deazaguanine

Journal of medicinal chemistry, 1993, Vol.36 (1), p.55-69

1993

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Search for New Purine- and Ribose-Modified Adenosine Analogs as Selective Agonists and Antagonists at Adenosine Receptors

Journal of medicinal chemistry, 1995-03, Vol.38 (7), p.1174-1188

1995

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Synthesis and Biological Activity of Certain 4‘-Thio-d-arabinofuranosylpurine Nucleosides

Journal of medicinal chemistry, 1998-09, Vol.41 (20), p.3865-3871

1998

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SYNTHESIS AND BIOLOGICAL ACTIVITY OF 2-FLUORO ADENINE AND 6-METHYL PURINE NUCLEOSIDE ANALOGS AS PRODRUGS FOR SUICIDE GENE THERAPY OF CANCER

Nucleosides, nucleotides & nucleic acids, 2005-01, Vol.24 (5-7), p.881-885

2005

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Differences in the metabolism and metabolic effects of the carbocyclic adenosine analogs, neplanocin A and aristeromycin

Molecular pharmacology, 1986-04, Vol.29 (4), p.383-390

1986

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Synthesis and biologic activity of 2'-fluoro-2-halo derivatives of 9-β-D-arabinofuranosyladenine

Journal of medicinal chemistry, 1992-01, Vol.35 (2), p.397-401

1992

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Bis(tBuSATE) phosphotriester prodrugs of 8-azaguanosine and 6-methylpurine riboside; bis(pom) phosphotriester prodrugs of 2'-deoxy-4'-thioadenosine and its corresponding 9alpha anomer

Nucleosides, nucleotides & nucleic acids, 2005, Vol.24 (5-7), p.809

2005

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Preclinical Antitumor Activity of 2-Chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)adenine (C1-F-Ara-A)

Nucleosides, nucleotides & nucleic acids, 2000-01, Vol.19 (1-2), p.447-460

2000

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SYNTHESIS AND BIOLOGICAL ACTIVITY OF 2′-DEOXY-4′-THIO-PYRAZOLO[3,4-d]PYRIMIDINE NUCLEOSIDES

Nucleosides, nucleotides & nucleic acids, 2005-01, Vol.24 (5-7), p.911-914

2005

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SYNTHESIS OF SOME 2′-FLUORO-2′-DEOXY-3′-C-ETHYNYL AND 3′-C-VINYL-β-D-LYXOFURANOSYL NUCLEOSIDES

Nucleosides, nucleotides & nucleic acids, 2005-01, Vol.24 (5-7), p.713-715

2005

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CHEMICAL AND ENZYMATIC SYNTHESIS OF 4′-THIO-β-D-ARABINOFURANOSYLCYTOSINE MONOPHOSPHATE AND TRIPHOSPHATE

Nucleosides, nucleotides & nucleic acids, 2005-01, Vol.24 (5-7), p.533-537

2005

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Synthesis and anti-HIV activity of 4'-thio-2',3'-dideoxynucleosides

Journal of medicinal chemistry, 1992-02, Vol.35 (3), p.533-538

1992

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Application of Crystallographic and Modeling Methods in the Design of Purine Nucleoside Phosphorylase Inhibitors

Thiarabine, 1-(4-Thio-β-D-arabinofuranosyl)cytosine. A Deoxycytidine Analog With Excellent Anticancer Activity

The Structural Basis for Substrate Specificity and Inhibition of Human S-Adenosylmethionine Decarboxylase

Programs to facilitate tuberculosis drug discovery: the tuberculosis antimicrobial acquisition and coordinating facility

Phosphorylation of the enantiomers of the carbocyclic analog of 2'-deoxyguanosine in cells infected with herpes simplex virus type 1 and in uninfected cells. Lack of enantiomeric selectivity with the viral thymidine kinase

Comparison of the Mechanism of Cytotoxicity of 2-Chloro-9-(2-deoxy-2-fluoro-Î²-d-arabinofuranosyl)adenine, 2-Chloro-9-(2-deoxy-2-fluoro-Î²-d-ribofuranosyl)adenine, and 2-Chloro-9-(2-deoxy-2,2-difluoro-Î²-d-ribofuranosyl)adenine in CEM Cells

In vivo gene therapy of cancer with E. coli purine nucleoside phosphorylase

Synthesis and biological activity of 2'-deoxy-4'-thio pyrimidine nucleosides

Structure−Activity Relationships of Bisphosphate Nucleotide Derivatives as P2Y1 Receptor Antagonists and Partial Agonists

Effects of 2-chloro-9-(3-deoxy-2-fluoro-β-D-arabinofuranosyl)adenine on K562 cellular metabolism and the inhibition of human ribonucleotide reductase and DNA polymerases by its 5'-triphosphate

Metabolism of 4′-thio-β- d-arabinofuranosylcytosine in CEM cells

Incorporation of the carbocyclic analog of 2'-deoxyguanosine into the DNA of herpes simplex virus and of HEp-2 cells infected with herpes simplex virus

Structure-based design of inhibitors of purine nucleoside phosphorylase. 1. 9-(Arylmethyl) derivatives of 9-deazaguanine

Search for New Purine- and Ribose-Modified Adenosine Analogs as Selective Agonists and Antagonists at Adenosine Receptors

Synthesis and Biological Activity of Certain 4‘-Thio-d-arabinofuranosylpurine Nucleosides

SYNTHESIS AND BIOLOGICAL ACTIVITY OF 2-FLUORO ADENINE AND 6-METHYL PURINE NUCLEOSIDE ANALOGS AS PRODRUGS FOR SUICIDE GENE THERAPY OF CANCER

Differences in the metabolism and metabolic effects of the carbocyclic adenosine analogs, neplanocin A and aristeromycin

Synthesis and biologic activity of 2'-fluoro-2-halo derivatives of 9-β-D-arabinofuranosyladenine

Bis(tBuSATE) phosphotriester prodrugs of 8-azaguanosine and 6-methylpurine riboside; bis(pom) phosphotriester prodrugs of 2'-deoxy-4'-thioadenosine and its corresponding 9alpha anomer

Preclinical Antitumor Activity of 2-Chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)adenine (C1-F-Ara-A)

SYNTHESIS AND BIOLOGICAL ACTIVITY OF 2′-DEOXY-4′-THIO-PYRAZOLO[3,4-d]PYRIMIDINE NUCLEOSIDES

SYNTHESIS OF SOME 2′-FLUORO-2′-DEOXY-3′-C-ETHYNYL AND 3′-C-VINYL-β-D-LYXOFURANOSYL NUCLEOSIDES

CHEMICAL AND ENZYMATIC SYNTHESIS OF 4′-THIO-β-D-ARABINOFURANOSYLCYTOSINE MONOPHOSPHATE AND TRIPHOSPHATE

Synthesis and anti-HIV activity of 4'-thio-2',3'-dideoxynucleosides

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