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Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity

Proceedings of the National Academy of Sciences - PNAS, 2007-05, Vol.104 (18), p.7391-7396

2007

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Ack1 mediated AKT/PKB tyrosine 176 phosphorylation regulates its activation

PloS one, 2010-03, Vol.5 (3), p.e9646-e9646

2010

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Ral GTPase Down-regulation Stabilizes and Reactivates p53 to Inhibit Malignant Transformation

The Journal of biological chemistry, 2014-11, Vol.289 (45), p.31296-31309

2014

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Targeting protein prenylation for cancer therapy

Nature reviews. Cancer, 2011-11, Vol.11 (11), p.775-791

2011

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MDMX Overexpression Prevents p53 Activation by the MDM2 Inhibitor Nutlin

The Journal of biological chemistry, 2006-11, Vol.281 (44), p.33030-33035

2006

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Regulation of dendritic cell differentiation and antitumor immune response in cancer by pharmacologic-selective inhibition of the janus-activated kinase 2/signal transducers and activators of transcription 3 pathway

Cancer research (Chicago, Ill.), 2005-10, Vol.65 (20), p.9525-9535

2005

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Phase II Study of the Mitogen-Activated Protein Kinase 1/2 Inhibitor Selumetinib in Patients With Advanced Hepatocellular Carcinoma

Journal of clinical oncology, 2011-06, Vol.29 (17), p.2350-2356

2011

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Consensus report of the 8 and 9th Weinman Symposia on Gene x Environment Interaction in carcinogenesis: novel opportunities for precision medicine

Cell death and differentiation, 2018-11, Vol.25 (11), p.1885-1904

2018

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Development of Highly Potent and Selective Diaminothiazole Inhibitors of Cyclin-Dependent Kinases

Journal of medicinal chemistry, 2013-05, Vol.56 (10), p.3768-3782

2013

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Discovery of a Novel Shp2 Protein Tyrosine Phosphatase Inhibitor

Molecular pharmacology, 2006-08, Vol.70 (2), p.562-570

2006

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Targeting protein tyrosine phosphatases for anticancer drug discovery

Current pharmaceutical design, 2010-06, Vol.16 (16), p.1843-1862

2010

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Activation of Dendritic Cells via Inhibition of Jak2/STAT3 Signaling

Journal of Immunology, 2005-10, Vol.175 (7), p.4338-4346

2005

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Novel mutant KRAS addiction signature predicts response to the combination of ERBB and MEK inhibitors in lung and pancreatic cancers

iScience, 2023-03, Vol.26 (3), p.106082-106082, Article 106082

2023

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GSK3 suppression upregulates β-catenin and c-Myc to abrogate KRas-dependent tumors

Nature communications, 2018-12, Vol.9 (1), p.5154-9, Article 5154

2018

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PTEN counteracts FBXL2 to promote IP3R3- and Ca 2+ -mediated apoptosis limiting tumour growth

Nature (London), 2017-06, Vol.546 (7659), p.554

2017

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PTEN counteracts FBXL2 to promote IP3R3- and Ca2+-mediated apoptosis limiting tumour growth

Nature (London), 2017-06, Vol.546 (7659), p.554-558

2017

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Phase I Trial of a Combination of the Multikinase Inhibitor Sorafenib and the Farnesyltransferase Inhibitor Tipifarnib in Advanced Malignancies

Clinical cancer research, 2009-11, Vol.15 (22), p.7061-7068

2009

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The GTPase KRAS suppresses the p53 tumor suppressor by activating the NRF2-regulated antioxidant defense system in cancer cells

The Journal of biological chemistry, 2020-03, Vol.295 (10), p.3055-3063

2020

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Phase II study of the farnesyltransferase inhibitor R115777 in advanced melanoma (CALGB 500104)

Journal of translational medicine, 2012-12, Vol.10 (1), p.246-246, Article 246

2012

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An Oxazole-Based Small-Molecule Stat3 Inhibitor Modulates Stat3 Stability and Processing and Induces Antitumor Cell Effects

ACS chemical biology, 2007-12, Vol.2 (12), p.787-798

2007

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Vitamin E δ-tocotrienol induces p27(Kip1)-dependent cell-cycle arrest in pancreatic cancer cells via an E2F-1-dependent mechanism

PloS one, 2013, Vol.8 (2), p.e52526

2013

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Vitamin E δ-tocotrienol sensitizes human pancreatic cancer cells to TRAIL-induced apoptosis through proteasome-mediated down-regulation of c-FLIPs

Cancer cell international, 2019-07, Vol.19 (1), p.189-189, Article 189

2019

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Inhibiting the interaction of cMET and IGF-1R with FAK effectively reduces growth of pancreatic cancer cells in vitro and in vivo

Anti-cancer agents in medicinal chemistry, 2013-05, Vol.13 (4), p.595-602

2013

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Fragment-Based and Structure-Guided Discovery and Optimization of Rho Kinase Inhibitors

Journal of medicinal chemistry, 2012-03, Vol.55 (5), p.2474-2478

2012

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A Novel Mechanism by Which Small Molecule Inhibitors Induce the DFG Flip in Aurora A

ACS chemical biology, 2012-04, Vol.7 (4), p.698-706

2012

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Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity

Ack1 mediated AKT/PKB tyrosine 176 phosphorylation regulates its activation

Ral GTPase Down-regulation Stabilizes and Reactivates p53 to Inhibit Malignant Transformation

Targeting protein prenylation for cancer therapy

MDMX Overexpression Prevents p53 Activation by the MDM2 Inhibitor Nutlin

Regulation of dendritic cell differentiation and antitumor immune response in cancer by pharmacologic-selective inhibition of the janus-activated kinase 2/signal transducers and activators of transcription 3 pathway

Phase II Study of the Mitogen-Activated Protein Kinase 1/2 Inhibitor Selumetinib in Patients With Advanced Hepatocellular Carcinoma

Consensus report of the 8 and 9th Weinman Symposia on Gene x Environment Interaction in carcinogenesis: novel opportunities for precision medicine

Development of Highly Potent and Selective Diaminothiazole Inhibitors of Cyclin-Dependent Kinases

Discovery of a Novel Shp2 Protein Tyrosine Phosphatase Inhibitor

Targeting protein tyrosine phosphatases for anticancer drug discovery

Activation of Dendritic Cells via Inhibition of Jak2/STAT3 Signaling

Novel mutant KRAS addiction signature predicts response to the combination of ERBB and MEK inhibitors in lung and pancreatic cancers

GSK3 suppression upregulates β-catenin and c-Myc to abrogate KRas-dependent tumors

PTEN counteracts FBXL2 to promote IP3R3- and Ca 2+ -mediated apoptosis limiting tumour growth

PTEN counteracts FBXL2 to promote IP3R3- and Ca2+-mediated apoptosis limiting tumour growth

Phase I Trial of a Combination of the Multikinase Inhibitor Sorafenib and the Farnesyltransferase Inhibitor Tipifarnib in Advanced Malignancies

The GTPase KRAS suppresses the p53 tumor suppressor by activating the NRF2-regulated antioxidant defense system in cancer cells

Phase II study of the farnesyltransferase inhibitor R115777 in advanced melanoma (CALGB 500104)

An Oxazole-Based Small-Molecule Stat3 Inhibitor Modulates Stat3 Stability and Processing and Induces Antitumor Cell Effects

Vitamin E δ-tocotrienol induces p27(Kip1)-dependent cell-cycle arrest in pancreatic cancer cells via an E2F-1-dependent mechanism

Vitamin E δ-tocotrienol sensitizes human pancreatic cancer cells to TRAIL-induced apoptosis through proteasome-mediated down-regulation of c-FLIPs

Inhibiting the interaction of cMET and IGF-1R with FAK effectively reduces growth of pancreatic cancer cells in vitro and in vivo

Fragment-Based and Structure-Guided Discovery and Optimization of Rho Kinase Inhibitors

A Novel Mechanism by Which Small Molecule Inhibitors Induce the DFG Flip in Aurora A

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