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Structure and Dynamics of Three Escherichia coli NfsB Nitro-Reductase Mutants Selected for Enhanced Activity with the Cancer Prodrug CB1954

International journal of molecular sciences, 2023-03, Vol.24 (6), p.5987

2023

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Viral gene therapy strategies: from basic science to clinical application

The Journal of pathology, 2006-01, Vol.208 (2), p.299-318

2006

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Minimal RB-responsive E1A Promoter Modification to Attain Potency, Selectivity, and Transgene-arming Capacity in Oncolytic Adenoviruses

Molecular therapy, 2010-11, Vol.18 (11), p.1960-1971

2010

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Co-stimulation with 4-1BB ligand allows extended T-cell proliferation, synergizes with CD80/CD86 and can reactivate anergic T cells

International immunology, 2007-12, Vol.19 (12), p.1383-1394

2007

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Vectors based on reducible polycations facilitate intracellular release of nucleic acids

The journal of gene medicine, 2003-03, Vol.5 (3), p.232-245

2003

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Oxygen‐insensitive nitroreductase E. coli NfsA, but not NfsB, is inhibited by fumarate

Proteins, structure, function, and bioinformatics, 2023-05, Vol.91 (5), p.585-592

2023

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Virus-Directed Enzyme Prodrug Therapy: Intratumoral Administration of a Replication-Deficient Adenovirus Encoding Nitroreductase to Patients With Resectable Liver Cancer

Journal of clinical oncology, 2004-05, Vol.22 (9), p.1546-1552

2004

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The structures of E. coli NfsA bound to the antibiotic nitrofurantoin; to 1,4-benzoquinone and to FMN

Biochemical journal, 2021-07, Vol.478 (13), p.2601-2617

2021

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The 3D‐structure, kinetics and dynamics of the E. coli nitroreductase NfsA with NADP+ provide glimpses of its catalytic mechanism

FEBS letters, 2022-09, Vol.596 (18), p.2425-2440

2022

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CD40 ligand induced cytotoxicity in carcinoma cells is enhanced by inhibition of metalloproteinase cleavage and delivery via a conditionally-replicating adenovirus

Molecular cancer, 2010-03, Vol.9 (1), p.52-52, Article 52

2010

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A phase I/II clinical trial in localized prostate cancer of an adenovirus expressing nitroreductase with CB1954 [correction of CB1984]

Molecular therapy, 2009-07, Vol.17 (7), p.1292-1299

2009

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A Phase I/II Clinical Trial in Localized Prostate Cancer of an Adenovirus Expressing Nitroreductase with CB1984

Molecular therapy, 2009-07, Vol.17 (7), p.1292-1299

2009

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Structural and mechanistic studies of Escherichia coli nitroreductase with the antibiotic nitrofurazone. Reversed binding orientations in different redox states of the enzyme

The Journal of biological chemistry, 2005-04, Vol.280 (14), p.13256-13264

2005

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Long-term proliferation of functional human NK cells, with conversion of CD56(dim) NK cells to a CD56 (bright) phenotype, induced by carcinoma cells co-expressing 4-1BBL and IL-12

Cancer immunology, immunotherapy, 2012-05, Vol.61 (5), p.615-628

2012

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Human Leukocyte Antigen (HLA) A1101-Restricted Epstein-Barr Virus-Specific T-cell Receptor Gene Transfer to Target Nasopharyngeal Carcinoma

Cancer immunology research, 2015-10, Vol.3 (10), p.1138-1147

2015

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Synthesis and structure-activity relationships of nitrobenzyl phosphoramide mustards as nitroreductase-activated prodrugs

Bioorganic & medicinal chemistry letters, 2011-07, Vol.21 (13), p.3986-3991

2011

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Kinetic and Structural Characterisation of Escherichia coli Nitroreductase Mutants Showing Improved Efficacy for the Prodrug Substrate CB1954

Journal of molecular biology, 2007-04, Vol.368 (2), p.481-492

2007

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Steady-State and Stopped-Flow Kinetic Studies of Three Escherichia coli NfsB Mutants with Enhanced Activity for the Prodrug CB1954

Biochemistry (Easton), 2009-08, Vol.48 (32), p.7665-7672

2009

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Prostate-specific antigen promoter/enhancer driven gene therapy for prostate cancer : Construction and testing of a tissue-specific adenovirus vector

Cancer research (Chicago, Ill.), 2000-01, Vol.60 (2), p.334-341

2000

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Testing double mutants of the enzyme nitroreductase for enhanced cell sensitisation to prodrugs: Effects of combining beneficial single mutations

Biochemical pharmacology, 2010-01, Vol.79 (2), p.102-111

2010

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4-1BBL costimulation retrieves CD28 expression in activated T cells

Cellular immunology, 2009, Vol.256 (1), p.39-46

2009

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Synergistic anti-tumor effects of nitroreductase mutants and p53

Journal of cancer research and therapeutics, 2014-07, Vol.10 (3), p.665-670

2014

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NITROREDUCTASE: A PRODRUG-ACTIVATING ENZYME FOR CANCER GENE THERAPY

Clinical and experimental pharmacology & physiology, 2004-11, Vol.31 (11), p.811-816

2004

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Generation of Escherichia coli nitroreductase mutants conferring improved cell sensitization to the prodrug CB1954

Cancer research (Chicago, Ill.), 2003-09, Vol.63 (17), p.5532-5537

2003

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The structure of Escherichia coli nitroreductase complexed with nicotinic acid: three crystal forms at 1.7 Å, 1.8 Å and 2.4 Å resolution

Journal of molecular biology, 2001-05, Vol.309 (1), p.203-213

2001

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Structure and Dynamics of Three Escherichia coli NfsB Nitro-Reductase Mutants Selected for Enhanced Activity with the Cancer Prodrug CB1954

Viral gene therapy strategies: from basic science to clinical application

Minimal RB-responsive E1A Promoter Modification to Attain Potency, Selectivity, and Transgene-arming Capacity in Oncolytic Adenoviruses

Co-stimulation with 4-1BB ligand allows extended T-cell proliferation, synergizes with CD80/CD86 and can reactivate anergic T cells

Vectors based on reducible polycations facilitate intracellular release of nucleic acids

Oxygen‐insensitive nitroreductase E. coli NfsA, but not NfsB, is inhibited by fumarate

Virus-Directed Enzyme Prodrug Therapy: Intratumoral Administration of a Replication-Deficient Adenovirus Encoding Nitroreductase to Patients With Resectable Liver Cancer

The structures of E. coli NfsA bound to the antibiotic nitrofurantoin; to 1,4-benzoquinone and to FMN

The 3D‐structure, kinetics and dynamics of the E. coli nitroreductase NfsA with NADP+ provide glimpses of its catalytic mechanism

CD40 ligand induced cytotoxicity in carcinoma cells is enhanced by inhibition of metalloproteinase cleavage and delivery via a conditionally-replicating adenovirus

A phase I/II clinical trial in localized prostate cancer of an adenovirus expressing nitroreductase with CB1954 [correction of CB1984]

A Phase I/II Clinical Trial in Localized Prostate Cancer of an Adenovirus Expressing Nitroreductase with CB1984

Structural and mechanistic studies of Escherichia coli nitroreductase with the antibiotic nitrofurazone. Reversed binding orientations in different redox states of the enzyme

Long-term proliferation of functional human NK cells, with conversion of CD56(dim) NK cells to a CD56 (bright) phenotype, induced by carcinoma cells co-expressing 4-1BBL and IL-12

Human Leukocyte Antigen (HLA) A1101-Restricted Epstein-Barr Virus-Specific T-cell Receptor Gene Transfer to Target Nasopharyngeal Carcinoma

Synthesis and structure-activity relationships of nitrobenzyl phosphoramide mustards as nitroreductase-activated prodrugs

Kinetic and Structural Characterisation of Escherichia coli Nitroreductase Mutants Showing Improved Efficacy for the Prodrug Substrate CB1954

Steady-State and Stopped-Flow Kinetic Studies of Three Escherichia coli NfsB Mutants with Enhanced Activity for the Prodrug CB1954

Prostate-specific antigen promoter/enhancer driven gene therapy for prostate cancer : Construction and testing of a tissue-specific adenovirus vector

Testing double mutants of the enzyme nitroreductase for enhanced cell sensitisation to prodrugs: Effects of combining beneficial single mutations

4-1BBL costimulation retrieves CD28 expression in activated T cells

Synergistic anti-tumor effects of nitroreductase mutants and p53

NITROREDUCTASE: A PRODRUG-ACTIVATING ENZYME FOR CANCER GENE THERAPY

Generation of Escherichia coli nitroreductase mutants conferring improved cell sensitization to the prodrug CB1954

The structure of Escherichia coli nitroreductase complexed with nicotinic acid: three crystal forms at 1.7 Å, 1.8 Å and 2.4 Å resolution

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