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Hyperpolarized [1- 13 C]-Pyruvate Magnetic Resonance Spectroscopic Imaging of Prostate Cancer In Vivo Predicts Efficacy of Targeting the Warburg Effect

Clinical cancer research, 2018-07, Vol.24 (13), p.3137-3148

2018

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Client Proteins and Small Molecule Inhibitors Display Distinct Binding Preferences for Constitutive and Stress-Induced HSP90 Isoforms and Their Conformationally Restricted Mutants

PloS one, 2015-10, Vol.10 (10), p.e0141786-e0141786

2015

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Mesenchymal stem cells inhibit cutaneous radiation‐induced fibrosis by suppressing chronic inflammation

Stem cells (Dayton, Ohio), 2013-10, Vol.31 (10), p.2231-2241

2013

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Truncated Plasminogen Activator Inhibitor-1 Protein Protects From Pulmonary Fibrosis Mediated by Irradiation in a Murine Model

International journal of radiation oncology, biology, physics, 2016-04, Vol.94 (5), p.1163-1172

2016

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An Acetylation Site in the Middle Domain of Hsp90 Regulates Chaperone Function

Molecular cell, 2007-01, Vol.25 (1), p.151-159

2007

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IL-13 is a therapeutic target in radiation lung injury

Scientific reports, 2016-12, Vol.6 (1), p.39714-39714, Article 39714

2016

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A structure-based designed small molecule depletes hRpn13Pru and a select group of KEN box proteins

Nature communications, 2024-03, Vol.15 (1), p.2485-18, Article 2485

2024

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Dynamic tyrosine phosphorylation modulates cycling of the HSP90-P50(CDC37)-AHA1 chaperone machine

Molecular cell, 2012-08, Vol.47 (3), p.434-443

2012

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Heat shock protein 90α (HSP90α), a substrate and chaperone of DNA-PK necessary for the apoptotic response

Proceedings of the National Academy of Sciences - PNAS, 2012-08, Vol.109 (32), p.12866-12872

2012

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Combinatorial drug design targeting multiple cancer signaling networks controlled by mitochondrial Hsp90

The Journal of clinical investigation, 2009-03, Vol.119 (3), p.454-464

2009

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Fumarate Hydratase Deficiency in Renal Cancer Induces Glycolytic Addiction and Hypoxia-Inducible Transcription Factor 1α Stabilization by Glucose-Dependent Generation of Reactive Oxygen Species

Molecular and Cellular Biology, 2009-08, Vol.29 (15), p.4080-4090

2009

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Senescence-associated tumor growth is promoted by 12-Lipoxygenase

Aging (Albany, NY.), 2022-02, Vol.14 (3), p.1068-1086

2022

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Functional proteomic screens reveal an essential extracellular role for hsp90α in cancer cell invasiveness

Nature cell biology, 2004-06, Vol.6 (6), p.507-514

2004

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Transforming growth factor alpha is a critical mediator of radiation lung injury

Radiation research, 2014-09, Vol.182 (3), p.350

2014

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Mithramycin A Enhances Tumor Sensitivity to Mitotic Catastrophe Resulting From DNA Damage

International journal of radiation oncology, biology, physics, 2018-02, Vol.100 (2), p.344-352

2018

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Characterization of the interaction of Aha1 with components of the Hsp90 chaperone machine and client proteins

Biochimica et biophysica acta, 2012-06, Vol.1823 (6), p.1092-1101

2012

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Targeting loss of the Hippo signaling pathway in NF2 -deficient papillary kidney cancers

Oncotarget, 2018-02, Vol.9 (12), p.10723-10733

2018

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Hsp90 charged-linker truncation reverses the functional consequences of weakened hydrophobic contacts in the N domain

Nature structural & molecular biology, 2009-11, Vol.16 (11), p.1141-1147

2009

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Just say NO: nitric oxide regulation of Hsp90

EMBO reports, 2009-10, Vol.10 (10), p.1093-1094

2009

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Tonantzitlolone cytotoxicity toward renal cancer cells is PKCθ- and HSF1-dependent

Oncotarget, 2015-10, Vol.6 (30), p.29963-29974

2015

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Dynamic Tyrosine Phosphorylation Modulates Cycling of the HSP90-P50CDC37-AHA1 Chaperone Machine

Molecular cell, 2012-08, Vol.47 (3), p.434-443

2012

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Abstract LB-184: Hyperpolarized 13C-pyruvate magnetic resonance spectroscopic imaging of prostate cancer tumor xenografts

Cancer research (Chicago, Ill.), 2016-07, Vol.76 (14_Supplement), p.LB-184-LB-184

2016

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MEK1/2 inhibition enhances the radiosensitivity of cancer cells by downregulating survival and growth signals mediated by EGFR ligands

International journal of oncology, 2013-06, Vol.42 (6), p.2028-2036

2013

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Post-translational modification of heat-shock protein 90: impact on chaperone function

Expert opinion on drug discovery, 2007-10, Vol.2 (10), p.1403-1414

2007

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High Affinity Binding of Hsp90 Is Triggered by Multiple Discrete Segments of Its Kinase Clients

Biochemistry (Easton), 2003-11, Vol.42 (43), p.12550-12561

2003

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Hyperpolarized [1- 13 C]-Pyruvate Magnetic Resonance Spectroscopic Imaging of Prostate Cancer In Vivo Predicts Efficacy of Targeting the Warburg Effect

Client Proteins and Small Molecule Inhibitors Display Distinct Binding Preferences for Constitutive and Stress-Induced HSP90 Isoforms and Their Conformationally Restricted Mutants

Mesenchymal stem cells inhibit cutaneous radiation‐induced fibrosis by suppressing chronic inflammation

Truncated Plasminogen Activator Inhibitor-1 Protein Protects From Pulmonary Fibrosis Mediated by Irradiation in a Murine Model

An Acetylation Site in the Middle Domain of Hsp90 Regulates Chaperone Function

IL-13 is a therapeutic target in radiation lung injury

A structure-based designed small molecule depletes hRpn13Pru and a select group of KEN box proteins

Dynamic tyrosine phosphorylation modulates cycling of the HSP90-P50(CDC37)-AHA1 chaperone machine

Heat shock protein 90α (HSP90α), a substrate and chaperone of DNA-PK necessary for the apoptotic response

Combinatorial drug design targeting multiple cancer signaling networks controlled by mitochondrial Hsp90

Fumarate Hydratase Deficiency in Renal Cancer Induces Glycolytic Addiction and Hypoxia-Inducible Transcription Factor 1α Stabilization by Glucose-Dependent Generation of Reactive Oxygen Species

Senescence-associated tumor growth is promoted by 12-Lipoxygenase

Functional proteomic screens reveal an essential extracellular role for hsp90α in cancer cell invasiveness

Transforming growth factor alpha is a critical mediator of radiation lung injury

Mithramycin A Enhances Tumor Sensitivity to Mitotic Catastrophe Resulting From DNA Damage

Characterization of the interaction of Aha1 with components of the Hsp90 chaperone machine and client proteins

Targeting loss of the Hippo signaling pathway in NF2 -deficient papillary kidney cancers

Hsp90 charged-linker truncation reverses the functional consequences of weakened hydrophobic contacts in the N domain

Just say NO: nitric oxide regulation of Hsp90

Tonantzitlolone cytotoxicity toward renal cancer cells is PKCθ- and HSF1-dependent

Dynamic Tyrosine Phosphorylation Modulates Cycling of the HSP90-P50CDC37-AHA1 Chaperone Machine

Abstract LB-184: Hyperpolarized 13C-pyruvate magnetic resonance spectroscopic imaging of prostate cancer tumor xenografts

MEK1/2 inhibition enhances the radiosensitivity of cancer cells by downregulating survival and growth signals mediated by EGFR ligands

Post-translational modification of heat-shock protein 90: impact on chaperone function

High Affinity Binding of Hsp90 Is Triggered by Multiple Discrete Segments of Its Kinase Clients

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