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Hexanucleotide Repeats in ALS/FTD Form Length-Dependent RNA Foci, Sequester RNA Binding Proteins, and Are Neurotoxic

Cell reports (Cambridge), 2013-12, Vol.5 (5), p.1178-1186

2013

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Differential roles of the ubiquitin proteasome system and autophagy in the clearance of soluble and aggregated TDP-43 species

Journal of cell science, 2014-03, Vol.127 (Pt 6), p.1263-1278

2014

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TDP-43 pathology: From noxious assembly to therapeutic removal

Progress in neurobiology, 2022-04, Vol.211, p.102229-102229, Article 102229

2022

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The heat shock response plays an important role in TDP-43 clearance: evidence for dysfunction in amyotrophic lateral sclerosis

Brain (London, England : 1878), 2016-05, Vol.139 (Pt 5), p.1417-1432

2016

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Transcriptional targets of amyotrophic lateral sclerosis/frontotemporal dementia protein TDP-43 – meta-analysis and interactive graphical database

Disease models & mechanisms, 2022-09, Vol.15 (9)

2022

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The endocannabinoid system as a target for the treatment of neurodegenerative disease

British journal of pharmacology, 2010-06, Vol.160 (3), p.480-498

2010

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ALS mutant FUS disrupts nuclear localization and sequesters wild-type FUS within cytoplasmic stress granules

Human molecular genetics, 2013-07, Vol.22 (13), p.2676-2688

2013

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TGF-beta1 regulates human brain pericyte inflammatory processes involved in neurovasculature function

Journal of neuroinflammation, 2016-02, Vol.13 (37), p.37-37, Article 37

2016

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ALS/FTD mutations in UBQLN2 impede autophagy by reducing autophagosome acidification through loss of function

Proceedings of the National Academy of Sciences - PNAS, 2020-06, Vol.117 (26), p.15230-15241

2020

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Altered microglia and neurovasculature in the Alzheimer's disease cerebellum

Neurobiology of disease, 2019-12, Vol.132, p.104589-104589, Article 104589

2019

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Cytoplasmic TDP-43 is involved in cell fate during stress recovery

Human molecular genetics, 2021-12, Vol.31 (2), p.166-175

2021

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A panel of TDP-43-regulated splicing events verifies loss of TDP-43 function in amyotrophic lateral sclerosis brain tissue

Neurobiology of disease, 2023-09, Vol.185, p.106245-106245, Article 106245

2023

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Serum biomarkers of neuroinflammation and blood-brain barrier leakage in amyotrophic lateral sclerosis

BMC neurology, 2022-06, Vol.22 (1), p.216-216, Article 216

2022

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PU.1 regulates Alzheimer's disease-associated genes in primary human microglia

Molecular neurodegeneration, 2018-08, Vol.13 (1), p.44-44, Article 44

2018

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Novel mutations support a role for Profilin 1 in the pathogenesis of ALS

Neurobiology of aging, 2015-03, Vol.36 (3), p.1602.e17-1602.e27

2015

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Microglial CD68 and L-ferritin upregulation in response to phosphorylated-TDP-43 pathology in the amyotrophic lateral sclerosis brain

Acta neuropathologica communications, 2023-04, Vol.11 (1), p.69-69, Article 69

2023

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Inconsistencies in histone acetylation patterns among different HD model systems and HD post-mortem brains

Neurobiology of disease, 2020-12, Vol.146, p.105092, Article 105092

2020

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Identification of a dysfunctional microglial population in human Alzheimer's disease cortex using novel single-cell histology image analysis

Acta neuropathologica communications, 2020-10, Vol.8 (1), p.170-170, Article 170

2020

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Allele-specific knockdown of ALS-associated mutant TDP-43 in neural stem cells derived from induced pluripotent stem cells

PloS one, 2014-03, Vol.9 (3), p.e91269

2014

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Shared Regulatory Pathways Reveal Novel Genetic Correlations Between Grip Strength and Neuromuscular Disorders

Frontiers in genetics, 2020-04, Vol.11, p.393-393

2020

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TDP-43 Proteinopathy and ALS: Insights into Disease Mechanisms and Therapeutic Targets

Neurotherapeutics, 2015-04, Vol.12 (2), p.352-363

2015

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Single-cell image analysis reveals a protective role for microglia in glioblastoma

Neuro-oncology advances, 2021-01, Vol.3 (1), p.vdab031-vdab031

2021

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Antisense oligonucleotide therapies for Amyotrophic Lateral Sclerosis: Existing and emerging targets

The international journal of biochemistry & cell biology, 2019-05, Vol.110, p.149-153

2019

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Markers for human brain pericytes and smooth muscle cells

Journal of chemical neuroanatomy, 2018-10, Vol.92, p.48-60

2018

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Induction of Krox-24 by Endogenous Cannabinoid Type 1 Receptors in Neuro2A Cells Is Mediated by the MEK-ERK MAPK Pathway and Is Suppressed by the Phosphatidylinositol 3-Kinase Pathway

The Journal of biological chemistry, 2006-09, Vol.281 (39), p.29085-29095

2006

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Hexanucleotide Repeats in ALS/FTD Form Length-Dependent RNA Foci, Sequester RNA Binding Proteins, and Are Neurotoxic

Differential roles of the ubiquitin proteasome system and autophagy in the clearance of soluble and aggregated TDP-43 species

TDP-43 pathology: From noxious assembly to therapeutic removal

The heat shock response plays an important role in TDP-43 clearance: evidence for dysfunction in amyotrophic lateral sclerosis

Transcriptional targets of amyotrophic lateral sclerosis/frontotemporal dementia protein TDP-43 – meta-analysis and interactive graphical database

The endocannabinoid system as a target for the treatment of neurodegenerative disease

ALS mutant FUS disrupts nuclear localization and sequesters wild-type FUS within cytoplasmic stress granules

TGF-beta1 regulates human brain pericyte inflammatory processes involved in neurovasculature function

ALS/FTD mutations in UBQLN2 impede autophagy by reducing autophagosome acidification through loss of function

Altered microglia and neurovasculature in the Alzheimer's disease cerebellum

Cytoplasmic TDP-43 is involved in cell fate during stress recovery

A panel of TDP-43-regulated splicing events verifies loss of TDP-43 function in amyotrophic lateral sclerosis brain tissue

Serum biomarkers of neuroinflammation and blood-brain barrier leakage in amyotrophic lateral sclerosis

PU.1 regulates Alzheimer's disease-associated genes in primary human microglia

Novel mutations support a role for Profilin 1 in the pathogenesis of ALS

Microglial CD68 and L-ferritin upregulation in response to phosphorylated-TDP-43 pathology in the amyotrophic lateral sclerosis brain

Inconsistencies in histone acetylation patterns among different HD model systems and HD post-mortem brains

Identification of a dysfunctional microglial population in human Alzheimer's disease cortex using novel single-cell histology image analysis

Allele-specific knockdown of ALS-associated mutant TDP-43 in neural stem cells derived from induced pluripotent stem cells

Shared Regulatory Pathways Reveal Novel Genetic Correlations Between Grip Strength and Neuromuscular Disorders

TDP-43 Proteinopathy and ALS: Insights into Disease Mechanisms and Therapeutic Targets

Single-cell image analysis reveals a protective role for microglia in glioblastoma

Antisense oligonucleotide therapies for Amyotrophic Lateral Sclerosis: Existing and emerging targets

Markers for human brain pericytes and smooth muscle cells

Induction of Krox-24 by Endogenous Cannabinoid Type 1 Receptors in Neuro2A Cells Is Mediated by the MEK-ERK MAPK Pathway and Is Suppressed by the Phosphatidylinositol 3-Kinase Pathway

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