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A Selective Transforming Growth Factor-β Ligand Trap Attenuates Pulmonary Hypertension

American journal of respiratory and critical care medicine, 2016-11, Vol.194 (9), p.1140-1151

2016

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ACTRIIA-Fc rebalances activin/GDF versus BMP signaling in pulmonary hypertension

Science translational medicine, 2020-05, Vol.12 (543)

2020

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Sotatercept analog suppresses inflammation to reverse experimental pulmonary arterial hypertension

Scientific reports, 2022-05, Vol.12 (1), p.7803-18, Article 7803

2022

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Soluble Endoglin Specifically Binds Bone Morphogenetic Proteins 9 and 10 via Its Orphan Domain, Inhibits Blood Vessel Formation, and Suppresses Tumor Growth

The Journal of biological chemistry, 2011-08, Vol.286 (34), p.30034-30046

2011

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Functionally diverse heteromeric traps for ligands of the transforming growth factor-β superfamily

Scientific reports, 2021-09, Vol.11 (1), p.18341-18341, Article 18341

2021

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Soluble activin receptor type IIB decoy receptor differentially impacts murine osteogenesis imperfecta muscle function

Muscle & nerve, 2018-02, Vol.57 (2), p.294-304

2018

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Administration of a soluble activin type IIB receptor promotes skeletal muscle growth independent of fiber type

Journal of applied physiology (1985), 2010-09, Vol.109 (3), p.635-642

2010

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Follistatin-288-Fc Fusion Protein Promotes Localized Growth of Skeletal Muscle

The Journal of pharmacology and experimental therapeutics, 2019-03, Vol.368 (3), p.435-445

2019

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Endothelial ALK1 Is a Therapeutic Target to Block Metastatic Dissemination of Breast Cancer

Cancer research (Chicago, Ill.), 2015-06, Vol.75 (12), p.2445-2456

2015

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A Soluble Activin Type IIA Receptor Induces Bone Formation and Improves Skeletal Integrity

Proceedings of the National Academy of Sciences - PNAS, 2008-05, Vol.105 (19), p.7082-7087

2008

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ALK1-Fc inhibits multiple mediators of angiogenesis and suppresses tumor growth

Molecular cancer therapeutics, 2010-02, Vol.9 (2), p.379-388

2010

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Characterization of the Ligand Binding Functionality of the Extracellular Domain of Activin Receptor Type IIB

The Journal of biological chemistry, 2010-07, Vol.285 (27), p.21037-21048

2010

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A soluble activin receptor Type IIA fusion protein (ACE-011) increases bone mass via a dual anabolic-antiresorptive effect in Cynomolgus monkeys

Bone (New York, N.Y.), 2010-04, Vol.46 (4), p.1082-1088

2010

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Use Of Ankle Immobilization In Evaluating Treatments To Promote Longitudinal Muscle Growth In Mice

Muscle & nerve, 2018-11, Vol.58 (5), p.718-725

2018

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soluble bone morphogenetic protein type IA receptor increases bone mass and bone strength

Proceedings of the National Academy of Sciences - PNAS, 2012-07, Vol.109 (30), p.12207-12212

2012

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Azoxymethane Is a Genetic Background-Dependent Colorectal Tumor Initiator and Promoter in Mice: Effects of Dose, Route, and Diet

Toxicological sciences, 2005-12, Vol.88 (2), p.340-345

2005

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Transforming growth factor-β superfamily ligand trap ACE-536 corrects anemia by promoting late-stage erythropoiesis

Nature medicine, 2014-04, Vol.20 (4), p.408-414

2014

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Epiregulin Is Not Essential for Development of Intestinal Tumors but Is Required for Protection from Intestinal Damage

Molecular and Cellular Biology, 2004-10, Vol.24 (20), p.8907-8916

2004

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Abstract 14397: Sotatercept Analog RAP-011 Inhibits Right Ventricular Remodeling and Restores Function in a Mouse Model of Pressure Overload

Circulation (New York, N.Y.), 2020-11, Vol.142 (Suppl_3 Suppl 3), p.A14397-A14397

2020

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Modified activin receptor IIB ligand trap mitigates ineffective erythropoiesis and disease complications in murine β-thalassemia

Blood, 2014-06, Vol.123 (25), p.3864-3872

2014

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Smad2/3‐pathway ligand trap luspatercept enhances erythroid differentiation in murine β‐thalassaemia by increasing GATA‐1 availability

Journal of cellular and molecular medicine, 2020-06, Vol.24 (11), p.6162-6177

2020

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Skeletal Response to Soluble Activin Receptor Type IIB in Mouse Models of Osteogenesis Imperfecta

Journal of bone and mineral research, 2018-10, Vol.33 (10), p.1760-1772

2018

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ActRIIB:ALK4-Fc alleviates muscle dysfunction and comorbidities in murine models of neuromuscular disorders

The Journal of clinical investigation, 2021-02, Vol.131 (4), p.1-16

2021

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Mapping six new susceptibility to colon cancer (Scc) loci using a mouse interspecific backcross

G3 : genes - genomes - genetics, 2012-12, Vol.2 (12), p.1577-1584

2012

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A New Polygenic Model for Nonfamilial Colorectal Cancer Inheritance Based on the Genetic Architecture of the Azoxymethane-Induced Mouse Model

Genetics (Austin), 2020-03, Vol.214 (3), p.691-702

2020

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A Selective Transforming Growth Factor-β Ligand Trap Attenuates Pulmonary Hypertension

ACTRIIA-Fc rebalances activin/GDF versus BMP signaling in pulmonary hypertension

Sotatercept analog suppresses inflammation to reverse experimental pulmonary arterial hypertension

Soluble Endoglin Specifically Binds Bone Morphogenetic Proteins 9 and 10 via Its Orphan Domain, Inhibits Blood Vessel Formation, and Suppresses Tumor Growth

Functionally diverse heteromeric traps for ligands of the transforming growth factor-β superfamily

Soluble activin receptor type IIB decoy receptor differentially impacts murine osteogenesis imperfecta muscle function

Administration of a soluble activin type IIB receptor promotes skeletal muscle growth independent of fiber type

Follistatin-288-Fc Fusion Protein Promotes Localized Growth of Skeletal Muscle

Endothelial ALK1 Is a Therapeutic Target to Block Metastatic Dissemination of Breast Cancer

A Soluble Activin Type IIA Receptor Induces Bone Formation and Improves Skeletal Integrity

ALK1-Fc inhibits multiple mediators of angiogenesis and suppresses tumor growth

Characterization of the Ligand Binding Functionality of the Extracellular Domain of Activin Receptor Type IIB

A soluble activin receptor Type IIA fusion protein (ACE-011) increases bone mass via a dual anabolic-antiresorptive effect in Cynomolgus monkeys

Use Of Ankle Immobilization In Evaluating Treatments To Promote Longitudinal Muscle Growth In Mice

soluble bone morphogenetic protein type IA receptor increases bone mass and bone strength

Azoxymethane Is a Genetic Background-Dependent Colorectal Tumor Initiator and Promoter in Mice: Effects of Dose, Route, and Diet

Transforming growth factor-β superfamily ligand trap ACE-536 corrects anemia by promoting late-stage erythropoiesis

Epiregulin Is Not Essential for Development of Intestinal Tumors but Is Required for Protection from Intestinal Damage

Abstract 14397: Sotatercept Analog RAP-011 Inhibits Right Ventricular Remodeling and Restores Function in a Mouse Model of Pressure Overload

Modified activin receptor IIB ligand trap mitigates ineffective erythropoiesis and disease complications in murine β-thalassemia

Smad2/3‐pathway ligand trap luspatercept enhances erythroid differentiation in murine β‐thalassaemia by increasing GATA‐1 availability

Skeletal Response to Soluble Activin Receptor Type IIB in Mouse Models of Osteogenesis Imperfecta

ActRIIB:ALK4-Fc alleviates muscle dysfunction and comorbidities in murine models of neuromuscular disorders

Mapping six new susceptibility to colon cancer (Scc) loci using a mouse interspecific backcross

A New Polygenic Model for Nonfamilial Colorectal Cancer Inheritance Based on the Genetic Architecture of the Azoxymethane-Induced Mouse Model

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