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Alleviating Cancer Drug Toxicity by Inhibiting a Bacterial Enzyme

Science (American Association for the Advancement of Science), 2010-11, Vol.330 (6005), p.831-835

2010

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Decorin core protein (decoron) shape complements collagen fibril surface structure and mediates its binding

PloS one, 2009-09, Vol.4 (9), p.e7028-e7028

2009

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MEKK2 mediates aberrant ERK activation in neurofibromatosis type I

Nature communications, 2020-11, Vol.11 (1), p.5704-5704, Article 5704

2020

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Estradiol enhances cell-associated paraoxonase 1 (PON1) activity in vitro without altering PON1 expression

Biochemical and biophysical research communications, 2010-07, Vol.397 (3), p.441-446

2010

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A high throughput proliferation and cytotoxicity assay for co-cultured isogenic cell lines

MethodsX, 2022-01, Vol.9, p.101927-101927, Article 101927

2022

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Proteodermatan and Proteokeratan Sulfate (Decorin, Lumican/Fibromodulin) Proteins Are Horseshoe Shaped. Implications for Their Interactions with Collagen

Biochemistry (Easton), 1996-07, Vol.35 (27), p.8795-8799

Scott, John. E

1996

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CoAsy knockdown in TNBC cell lines resulted in no overt effect on cell proliferation in vitro

Biochemical and biophysical research communications, 2020-09, Vol.530 (1), p.136-141

2020

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Cartilage elasticity resides in shape module decoran and aggrecan sumps of damping fluid: implications in osteoarthrosis

The Journal of physiology, 2006-08, Vol.574 (3), p.643-650

2006

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Cartilage is held together by elastic glycan strings. Physiological and pathological implications

Biorheology (Oxford), 2008, Vol.45 (3-4), p.209

Scott, John E

2008

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Development and validation of a high-throughput intrinsic ATPase activity assay for the discovery of MEKK2 inhibitors

Journal of biomolecular screening, 2013-04, Vol.18 (4), p.388-399

2013

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Diagnosis and outcome of fetal lower urinary tract obstruction in the northern region of England

Prenatal diagnosis, 2005-01, Vol.25 (1), p.7-13

2005

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Toward the Effective Surveillance of Hypospadias

Environmental health perspectives, 2004-03, Vol.112 (3), p.398-402

2004

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Identification of ponatinib and other known kinase inhibitors with potent MEKK2 inhibitory activity

Biochemical and biophysical research communications, 2015-08, Vol.463 (4), p.888-893

2015

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Old Drug New Use―Amoxapine and Its Metabolites as Potent Bacterial β-Glucuronidase Inhibitors for Alleviating Cancer Drug Toxicity

Clinical cancer research, 2014-07, Vol.20 (13), p.3521-3530

2014

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Identification of a Triple Drug Combination That Is Synergistically Cytotoxic for Triple-Negative Breast Cancer Cells Using a Novel Combination Discovery Approach

SLAS discovery, 2020-09, Vol.25 (8), p.923-938

2020

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Discovery of Cercosporamide, a Known Antifungal Natural Product, as a Selective Pkc1 Kinase Inhibitor through High-Throughput Screening

Eukaryotic Cell, 2004-08, Vol.3 (4), p.932-943

2004

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Discovery and characterization of an iminocoumarin scaffold as an inhibitor of MEKK2 (MAP3K2)

Biochemical and biophysical research communications, 2018-01, Vol.496 (1), p.205-211

2018

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A universal competitive fluorescence polarization activity assay for S-adenosylmethionine utilizing methyltransferases

Analytical biochemistry, 2008-02, Vol.373 (2), p.296-306

2008

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Potential repurposing of known drugs as potent bacterial β-glucuronidase inhibitors

Journal of biomolecular screening, 2012-08, Vol.17 (7), p.957-965

2012

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Bosutinib reduces the efficacy of Dasatinib in triple-negative breast cancer cell lines

Anticancer research, 2014-04, Vol.34 (4), p.1629-1635

2014

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Biological Properties of Hyaluronan in Aqueous Solution Are Controlled and Sequestered by Reversible Tertiary Structures, Defined by NMR Spectroscopy

Biomacromolecules, 2002-05, Vol.3 (3), p.547-553

2002

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A homogeneous cell-based assay for measurement of endogenous paraoxonase 1 activity

Analytical biochemistry, 2010-05, Vol.400 (1), p.1-9

2010

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Enzyme assay design for high-throughput screening

Methods in molecular biology (Clifton, N.J.), 2009-01, Vol.565, p.107

2009

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Supramolecular organization of extracellular matrix glycosaminoglycans, in vitro and in the tissues

The FASEB journal, 1992-06, Vol.6 (9), p.2639-2645

Scott, John E.

1992

Volltextzugriff (PDF)

Stretching Single Molecules of Connective Tissue Glycans to Characterize Their Shape-Maintaining Elasticity

Biomacromolecules, 2005-05, Vol.6 (3), p.1816-1818

2005

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Alleviating Cancer Drug Toxicity by Inhibiting a Bacterial Enzyme

Decorin core protein (decoron) shape complements collagen fibril surface structure and mediates its binding

MEKK2 mediates aberrant ERK activation in neurofibromatosis type I

Estradiol enhances cell-associated paraoxonase 1 (PON1) activity in vitro without altering PON1 expression

A high throughput proliferation and cytotoxicity assay for co-cultured isogenic cell lines

Proteodermatan and Proteokeratan Sulfate (Decorin, Lumican/Fibromodulin) Proteins Are Horseshoe Shaped. Implications for Their Interactions with Collagen

CoAsy knockdown in TNBC cell lines resulted in no overt effect on cell proliferation in vitro

Cartilage elasticity resides in shape module decoran and aggrecan sumps of damping fluid: implications in osteoarthrosis

Cartilage is held together by elastic glycan strings. Physiological and pathological implications

Development and validation of a high-throughput intrinsic ATPase activity assay for the discovery of MEKK2 inhibitors

Diagnosis and outcome of fetal lower urinary tract obstruction in the northern region of England

Toward the Effective Surveillance of Hypospadias

Identification of ponatinib and other known kinase inhibitors with potent MEKK2 inhibitory activity

Old Drug New Use―Amoxapine and Its Metabolites as Potent Bacterial β-Glucuronidase Inhibitors for Alleviating Cancer Drug Toxicity

Identification of a Triple Drug Combination That Is Synergistically Cytotoxic for Triple-Negative Breast Cancer Cells Using a Novel Combination Discovery Approach

Discovery of Cercosporamide, a Known Antifungal Natural Product, as a Selective Pkc1 Kinase Inhibitor through High-Throughput Screening

Discovery and characterization of an iminocoumarin scaffold as an inhibitor of MEKK2 (MAP3K2)

A universal competitive fluorescence polarization activity assay for S-adenosylmethionine utilizing methyltransferases

Potential repurposing of known drugs as potent bacterial β-glucuronidase inhibitors

Bosutinib reduces the efficacy of Dasatinib in triple-negative breast cancer cell lines

Biological Properties of Hyaluronan in Aqueous Solution Are Controlled and Sequestered by Reversible Tertiary Structures, Defined by NMR Spectroscopy

A homogeneous cell-based assay for measurement of endogenous paraoxonase 1 activity

Enzyme assay design for high-throughput screening

Supramolecular organization of extracellular matrix glycosaminoglycans, in vitro and in the tissues

Stretching Single Molecules of Connective Tissue Glycans to Characterize Their Shape-Maintaining Elasticity

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