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Peptide Macrocyclization Inspired by Non-Ribosomal Imine Natural Products

Journal of the American Chemical Society, 2017-04, Vol.139 (14), p.5233-5241

2017

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A General Amino Acid Synthesis Enabled by Innate Radical Cross‐Coupling

Angewandte Chemie International Edition, 2018-10, Vol.57 (44), p.14560-14565

International ed. in English, 2018

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Synthetic studies toward a simplified eleuthoside core

Medicinal chemistry research, 2023-07, Vol.32 (7), p.1376-1382

2023

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Potent Inhibitors of Hepatitis C Virus NS3 Protease: Employment of a Difluoromethyl Group as a Hydrogen-Bond Donor

ACS medicinal chemistry letters, 2018-02, Vol.9 (2), p.143-148

2018

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Ligand-Enabled β‑C–H Arylation of α‑Amino Acids Using a Simple and Practical Auxiliary

Journal of the American Chemical Society, 2015-03, Vol.137 (9), p.3338-3351

2015

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Room‐Temperature Copper‐Catalyzed Etherification of Aryl Bromides

Angewandte Chemie International Edition, 2024-05, Vol.63 (19), p.e202400333-n/a

International ed. in English, 2024

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Cu-Catalyzed Amination of Base-Sensitive Aryl Bromides and the Chemoselective N- and O‑Arylation of Amino Alcohols

Journal of the American Chemical Society, 2024-07, Vol.146 (27), p.18616-18625

2024

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Deoxyfluorination of 1°, 2°, and 3° Alcohols by Nonbasic O–H Activation and Lewis Acid-Catalyzed Fluoride Shuttling

Journal of the American Chemical Society, 2023-10, Vol.145 (41), p.22735-22744

2023

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Challenges with the Synthesis of a Macrocyclic Thioether Peptide: From Milligram to Multigram Using Solid Phase Peptide Synthesis (SPPS)

Journal of organic chemistry, 2024-05, Vol.89 (10), p.6639-6650

2024

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The discovery and evaluation of [18F]BMS-986229, a novel macrocyclic peptide PET radioligand for the measurement of PD-L1 expression and in-vivo PD-L1 target engagement

European journal of nuclear medicine and molecular imaging, 2024-03, Vol.51 (4), p.978-990

2024

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Discovery and Early Clinical Evaluation of BMS-605339, a Potent and Orally Efficacious Tripeptidic Acylsulfonamide NS3 Protease Inhibitor for the Treatment of Hepatitis C Virus Infection

Journal of medicinal chemistry, 2014-03, Vol.57 (5), p.1708-1729

2014

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Development, Characterization, and Radiation Dosimetry Studies of 18F-BMS-986229, a 18F-Labeled PD-L1 Macrocyclic Peptide PET Tracer

Molecular imaging and biology, 2024-04, Vol.26 (2), p.301-309

2024

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P3-P4 ureas and reverse carbamates as potent HCV NS3 protease inhibitors: Effective transposition of the P4 hydrogen bond donor

Bioorganic & medicinal chemistry letters, 2018-06, Vol.28 (10), p.1853-1859

2018

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The discovery and optimization of naphthalene-linked P2-P4 Macrocycles as inhibitors of HCV NS3 protease

Bioorganic & medicinal chemistry letters, 2018-01, Vol.28 (1), p.43-48

2018

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Room‐Temperature Copper‐Catalyzed Etherification of Aryl Bromides

Angewandte Chemie, 2024-05, Vol.136 (19), p.n/a

2024

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Total synthesis of halichondrin B and norhalichondrin B

Journal of the American Chemical Society, 1992-04, Vol.114 (8), p.3162-3164

1992

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Structure-activity relationships of 4-hydroxy-4-biaryl-proline acylsulfonamide tripeptides: A series of potent NS3 protease inhibitors for the treatment of hepatitis C virus

Bioorganic & medicinal chemistry letters, 2017-02, Vol.27 (3), p.590-596

2017

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Structure activity relationship studies of 3-arylsulfonyl-pyrido[1,2-a]pyrimidin-4-imines as potent 5-HT6 antagonists

Bioorganic & medicinal chemistry, 2014-03, Vol.22 (5), p.1782-1790

2014

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Functionalized triazines as potent HCV entry inhibitors

Bioorganic & medicinal chemistry letters, 2017-02, Vol.27 (4), p.1089-1093

2017

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A General Amino Acid Synthesis Enabled by Innate Radical Cross‐Coupling

Angewandte Chemie, 2018-10, Vol.130 (44), p.14768-14773

2018

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Identification of a Potent and Selective 5-HT6 Antagonist: One-Step Synthesis of (E)-3-(Benzenesulfonyl)-2- (methylsulfanyl)pyrido[1,2-a]pyrimidin- 4-ylidenamine from 2-(Benzenesulfonyl)-3,3- bis(methylsulfanyl)acrylonitrile

Journal of medicinal chemistry, 2003-11, Vol.46 (23), p.4834-4837

2003

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The Discovery of Asunaprevir (BMS-650032), An Orally Efficacious NS3 Protease Inhibitor for the Treatment of Hepatitis C Virus Infection

Journal of medicinal chemistry, 2014-03, Vol.57 (5), p.1730-1752

2014

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2-Arylaminothiazoles as high-affinity corticotropin-Releasing factor 1 receptor (CRF 1R) antagonists: synthesis, binding studies and behavioral efficacy

Bioorganic & medicinal chemistry letters, 2003-11, Vol.13 (22), p.3997-4000

2003

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Discovery of a Potent Acyclic, Tripeptidic, Acyl Sulfonamide Inhibitor of Hepatitis C Virus NS3 Protease as a Back-up to Asunaprevir with the Potential for Once-Daily Dosing

Journal of medicinal chemistry, 2016-09, Vol.59 (17), p.8042-8060

2016

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Peptide Macrocyclization Inspired by Non-Ribosomal Imine Natural Products

A General Amino Acid Synthesis Enabled by Innate Radical Cross‐Coupling

Synthetic studies toward a simplified eleuthoside core

Potent Inhibitors of Hepatitis C Virus NS3 Protease: Employment of a Difluoromethyl Group as a Hydrogen-Bond Donor

Ligand-Enabled β‑C–H Arylation of α‑Amino Acids Using a Simple and Practical Auxiliary

Room‐Temperature Copper‐Catalyzed Etherification of Aryl Bromides

Cu-Catalyzed Amination of Base-Sensitive Aryl Bromides and the Chemoselective N- and O‑Arylation of Amino Alcohols

Deoxyfluorination of 1°, 2°, and 3° Alcohols by Nonbasic O–H Activation and Lewis Acid-Catalyzed Fluoride Shuttling

Challenges with the Synthesis of a Macrocyclic Thioether Peptide: From Milligram to Multigram Using Solid Phase Peptide Synthesis (SPPS)

The discovery and evaluation of [18F]BMS-986229, a novel macrocyclic peptide PET radioligand for the measurement of PD-L1 expression and in-vivo PD-L1 target engagement

Discovery and Early Clinical Evaluation of BMS-605339, a Potent and Orally Efficacious Tripeptidic Acylsulfonamide NS3 Protease Inhibitor for the Treatment of Hepatitis C Virus Infection

Development, Characterization, and Radiation Dosimetry Studies of 18F-BMS-986229, a 18F-Labeled PD-L1 Macrocyclic Peptide PET Tracer

P3-P4 ureas and reverse carbamates as potent HCV NS3 protease inhibitors: Effective transposition of the P4 hydrogen bond donor

The discovery and optimization of naphthalene-linked P2-P4 Macrocycles as inhibitors of HCV NS3 protease

Room‐Temperature Copper‐Catalyzed Etherification of Aryl Bromides

Total synthesis of halichondrin B and norhalichondrin B

Structure-activity relationships of 4-hydroxy-4-biaryl-proline acylsulfonamide tripeptides: A series of potent NS3 protease inhibitors for the treatment of hepatitis C virus

Structure activity relationship studies of 3-arylsulfonyl-pyrido[1,2-a]pyrimidin-4-imines as potent 5-HT6 antagonists

Functionalized triazines as potent HCV entry inhibitors

A General Amino Acid Synthesis Enabled by Innate Radical Cross‐Coupling

Identification of a Potent and Selective 5-HT6 Antagonist: One-Step Synthesis of (E)-3-(Benzenesulfonyl)-2- (methylsulfanyl)pyrido[1,2-a]pyrimidin- 4-ylidenamine from 2-(Benzenesulfonyl)-3,3- bis(methylsulfanyl)acrylonitrile

The Discovery of Asunaprevir (BMS-650032), An Orally Efficacious NS3 Protease Inhibitor for the Treatment of Hepatitis C Virus Infection

Discovery of BMS-986144, a Third-Generation, Pan-Genotype NS3/4A Protease Inhibitor for the Treatment of Hepatitis C Virus Infection

2-Arylaminothiazoles as high-affinity corticotropin-Releasing factor 1 receptor (CRF 1R) antagonists: synthesis, binding studies and behavioral efficacy

Discovery of a Potent Acyclic, Tripeptidic, Acyl Sulfonamide Inhibitor of Hepatitis C Virus NS3 Protease as a Back-up to Asunaprevir with the Potential for Once-Daily Dosing

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