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Mechanistic Evaluation of the Complex Drug-Drug Interactions of Maraviroc: Contribution of Cytochrome P450 3A, P-Glycoprotein and Organic Anion Transporting Polypeptide 1B1

Drug metabolism and disposition, 2019-05, Vol.47 (5), p.493-503

2019

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Reliable Rate Measurements for Active and Passive Hepatic Uptake Using Plated Human Hepatocytes

The AAPS journal, 2017-05, Vol.19 (3), p.787-796

2017

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Multidrug Resistance-Associated Protein 3 Plays an Important Role in Protection against Acute Toxicity of Diclofenac

Drug metabolism and disposition, 2015-07, Vol.43 (7), p.944-950

2015

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Positive allosteric modulation of AMPA receptors from efficacy to toxicity: the interspecies exposure-response continuum of the novel potentiator PF-4778574

The Journal of pharmacology and experimental therapeutics, 2013-10, Vol.347 (1), p.212-224

2013

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The modulation of transcriptional expression and inhibition of multidrug resistance associated protein 4 (MRP4) by analgesics and their primary metabolites

Current research in toxicology, 2020-06, Vol.1, p.34-41

2020

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Xenobiotic Transporters in the Kidney: Function and Role in Toxicity

Seminars in nephrology, 2019-03, Vol.39 (2), p.159-175

2019

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Elucidation of the Mechanisms through Which the Reactive Metabolite Diclofenac Acyl Glucuronide Can Mediate Toxicity

The Journal of pharmacology and experimental therapeutics, 2016-04, Vol.357 (1), p.167-176

2016

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Identification and Characterization of Efflux Transporters That Modulate the Subtoxic Disposition of Diclofenac and Its Metabolites

Drug metabolism and disposition, 2019-10, Vol.47 (10), p.1080-1092

2019

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Hepatic Disposition of Gemfibrozil and Its Major Metabolite Gemfibrozil 1‑O‑β-Glucuronide

Molecular pharmaceutics, 2015-11, Vol.12 (11), p.3943-3952

2015

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Evaluation of Hepatic Uptake of OATP1B Substrates by Short Term-Cultured Plated Human Hepatocytes: Comparison With Isolated Suspended Hepatocytes

Journal of pharmaceutical sciences, 2021-01, Vol.110 (1), p.376-387

2021

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Cell-to-Medium Concentration Ratio Overshoot in the Uptake of Statins by Human Hepatocytes in Suspension, but Not in Monolayer: Kinetic Analysis Suggesting a Partial Loss of Functional OATP1Bs

The AAPS journal, 2020-10, Vol.22 (6), Article 133

2020

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Detection of statin cytotoxicity is increased in cells expressing the OATP1B1 transporter

Toxicological sciences, 2013-07, Vol.134 (1), p.73-82

2013

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Mechanism-Based Pharmacokinetic Modeling to Evaluate Transporter-Enzyme Interplay in Drug Interactions and Pharmacogenetics of Glyburide

The AAPS journal, 2014-07, Vol.16 (4), p.736-748

2014

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The Antimicrobial Agent Fusidic Acid Inhibits Organic Anion Transporting Polypeptide-Mediated Hepatic Clearance and May Potentiate Statin-Induced Myopathy

Drug metabolism and disposition, 2016-05, Vol.44 (5), p.692-699

2016

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Transporter-Mediated Disposition, Clinical Pharmacokinetics and Cholestatic Potential of Glyburide and Its Primary Active Metabolites

Drug metabolism and disposition, 2017-07, Vol.45 (7), p.737-747

2017

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Discovery and Characterization of a Novel Dihydroisoxazole Class of α‑Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) Receptor Potentiators

Journal of medicinal chemistry, 2013-11, Vol.56 (22), p.9180-9191

2013

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Erratum to: Reliable Rate Measurements for Active and Passive Hepatic Uptake Using Plated Human Hepatocytes

The AAPS journal, 2017-05, Vol.19 (3), p.882-882

2017

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Using Simcyp to project human oral pharmacokinetic variability in early drug research to mitigate mechanism-based adverse events

Biopharmaceutics & drug disposition, 2012-03, Vol.33 (2), p.72-84

2012

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Metabolism and disposition of a selective alpha(7) nicotinic acetylcholine receptor agonist in humans

Drug metabolism and disposition, 2007-07, Vol.35 (7), p.1188

2007

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Elucidation of the biochemical basis for a clinical drug-drug interaction between atorvastatin and 5-(N-(4-((4-ethylbenzyl)thio)phenyl)sulfamoyl)-2-methyl benzoic acid (CP-778 875), a subtype selective agonist of the peroxisome proliferator-activated receptor alpha

Xenobiotica, 2013-11, Vol.43 (11), p.963-972

2013

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Mechanistic investigation of liver injury induced by BMS-932481, an experimental ɣ-secretase modulator

Toxicological sciences, 2023-07, Vol.194 (2), p.235-245

2023

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Metabolism and Disposition of a Selective α 7 Nicotinic Acetylcholine Receptor Agonist in Humans

Drug metabolism and disposition, 2007-07, Vol.35 (7), p.1188-1195

2007

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Inhibition of Hepatobiliary Transport Activity by the Antibacterial Agent Fusidic Acid: Insights into Factors Contributing to Conjugated Hyperbilirubinemia/Cholestasis

Chemical research in toxicology, 2016-10, Vol.29 (10), p.1778-1788

2016

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Mechanistic Evaluation of the Complex Drug-Drug Interactions of Maraviroc: Contribution of Cytochrome P450 3A, P-Glycoprotein and Organic Anion Transporting Polypeptide 1B1

Reliable Rate Measurements for Active and Passive Hepatic Uptake Using Plated Human Hepatocytes

Multidrug Resistance-Associated Protein 3 Plays an Important Role in Protection against Acute Toxicity of Diclofenac

Positive allosteric modulation of AMPA receptors from efficacy to toxicity: the interspecies exposure-response continuum of the novel potentiator PF-4778574

The modulation of transcriptional expression and inhibition of multidrug resistance associated protein 4 (MRP4) by analgesics and their primary metabolites

Xenobiotic Transporters in the Kidney: Function and Role in Toxicity

Elucidation of the Mechanisms through Which the Reactive Metabolite Diclofenac Acyl Glucuronide Can Mediate Toxicity

Identification and Characterization of Efflux Transporters That Modulate the Subtoxic Disposition of Diclofenac and Its Metabolites

Hepatic Disposition of Gemfibrozil and Its Major Metabolite Gemfibrozil 1‑O‑β-Glucuronide

Evaluation of Hepatic Uptake of OATP1B Substrates by Short Term-Cultured Plated Human Hepatocytes: Comparison With Isolated Suspended Hepatocytes

Cell-to-Medium Concentration Ratio Overshoot in the Uptake of Statins by Human Hepatocytes in Suspension, but Not in Monolayer: Kinetic Analysis Suggesting a Partial Loss of Functional OATP1Bs

Detection of statin cytotoxicity is increased in cells expressing the OATP1B1 transporter

Mechanism-Based Pharmacokinetic Modeling to Evaluate Transporter-Enzyme Interplay in Drug Interactions and Pharmacogenetics of Glyburide

The Antimicrobial Agent Fusidic Acid Inhibits Organic Anion Transporting Polypeptide-Mediated Hepatic Clearance and May Potentiate Statin-Induced Myopathy

Transporter-Mediated Disposition, Clinical Pharmacokinetics and Cholestatic Potential of Glyburide and Its Primary Active Metabolites

The Discovery and Characterization of the α‑Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Potentiator N‑{(3S,4S)‑4-[4-(5-Cyano-2-thienyl)phenoxy]tetrahydrofuran-3-yl}propane-2-sulfonamide (PF-04958242)

Discovery and Characterization of a Novel Dihydroisoxazole Class of α‑Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) Receptor Potentiators

Erratum to: Reliable Rate Measurements for Active and Passive Hepatic Uptake Using Plated Human Hepatocytes

Using Simcyp to project human oral pharmacokinetic variability in early drug research to mitigate mechanism-based adverse events

Metabolism and disposition of a selective alpha(7) nicotinic acetylcholine receptor agonist in humans

Elucidation of the biochemical basis for a clinical drug-drug interaction between atorvastatin and 5-(N-(4-((4-ethylbenzyl)thio)phenyl)sulfamoyl)-2-methyl benzoic acid (CP-778 875), a subtype selective agonist of the peroxisome proliferator-activated receptor alpha

Mechanistic investigation of liver injury induced by BMS-932481, an experimental ɣ-secretase modulator

Metabolism and Disposition of a Selective α 7 Nicotinic Acetylcholine Receptor Agonist in Humans

Inhibition of Hepatobiliary Transport Activity by the Antibacterial Agent Fusidic Acid: Insights into Factors Contributing to Conjugated Hyperbilirubinemia/Cholestasis

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