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Beta Cell Imaging-From Pre-Clinical Validation to First in Man Testing

International journal of molecular sciences, 2020-10, Vol.21 (19), p.7274

2020

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Combined blockade of EGFR and glutamine metabolism in preclinical models of colorectal cancer

Translational oncology, 2020-10, Vol.13 (10), p.100828-100828, Article 100828

2020

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Skeletal muscle metabolic responses to physical activity are muscle type specific in a rat model of chronic kidney disease

Scientific reports, 2021-05, Vol.11 (1), p.9788-9788, Article 9788

2021

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Substituted indoles as selective protease activated receptor 4 (PAR-4) antagonists: Discovery and SAR of ML354

Bioorganic & medicinal chemistry letters, 2014-10, Vol.24 (19), p.4708-4713

2014

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Synthesis of indole derived protease-activated receptor 4 antagonists and characterization in human platelets

PloS one, 2013-06, Vol.8 (6), p.e65528-e65528

2013

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Pharmacological blockade of ASCT2-dependent glutamine transport leads to antitumor efficacy in preclinical models

Nature medicine, 2018-02, Vol.24 (2), p.194-202

2018

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General Access to Chiral N-Alkyl Terminal Aziridines via Organocatalysis

Organic letters, 2010-07, Vol.12 (14), p.3276-3278

2010

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Mutant KRAS Exosomes Alter the Metabolic State of Recipient Colonic Epithelial Cells

Cellular and molecular gastroenterology and hepatology, 2018-01, Vol.5 (4), p.627-629.e6

2018

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Hybrid 18F-Fluoroethyltyrosine PET and MRI with Perfusion to Distinguish Disease Progression from Treatment-Related Change in Malignant Brain Tumors: The Quest to Beat the Toughest Cases

The Journal of nuclear medicine (1978), 2023-07, Vol.64 (7), p.1087-1092

2023

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Hybrid 18 F-Fluoroethyltyrosine PET and MRI with Perfusion to Distinguish Disease Progression from Treatment-Related Change in Malignant Brain Tumors: The Quest to Beat the Toughest Cases

Journal of Nuclear Medicine, 2023-07, Vol.64 (7), p.1087-1092

2023

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2-Amino-4-bis(aryloxybenzyl)aminobutanoic acids: A novel scaffold for inhibition of ASCT2-mediated glutamine transport

Bioorganic & medicinal chemistry letters, 2016-02, Vol.26 (3), p.1044-1047

2016

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Highly Diastereoselective and General Synthesis of Primary β-Fluoroamines

Organic letters, 2011-10, Vol.13 (20), p.5684-5687

2011

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Positive allosteric modulators (PAMs) of the group II metabotropic glutamate receptors: Design, synthesis, and evaluation as ex-vivo tool compounds

Bioorganic & medicinal chemistry letters, 2021-10, Vol.50, p.128342-128342, Article 128342

2021

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Automated radiosynthesis of 5-[11C]l-glutamine, an important tracer for glutamine utilization

Nuclear medicine and biology, 2018-12, Vol.67, p.10-14

2018

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2-Substituted Nγ-glutamylanilides as novel probes of ASCT2 with improved potency

Bioorganic & medicinal chemistry letters, 2015-01, Vol.25 (1), p.113-116

2015

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Optimized Translocator Protein Ligand for Optical Molecular Imaging and Screening

Bioconjugate chemistry, 2017-04, Vol.28 (4), p.1016-1023

2017

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New structure–activity relationships of N-acetamide substituted pyrazolopyrimidines as pharmacological ligands of TSPO

Bioorganic & medicinal chemistry letters, 2016-08, Vol.26 (15), p.3472-3477

2016

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Further exploration of an N-aryl phenoxyethoxy pyridinone-based series of mGlu3 NAMs: Challenging SAR, enantiospecific activity and in vivo efficacy

Bioorganic & medicinal chemistry letters, 2019-09, Vol.29 (18), p.2670-2674

2019

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Total Synthesis of Stemaphylline N-Oxide and Related C9a-Epimeric Analogues

Chemistry : a European journal, 2013-09, Vol.19 (36), p.11847-11852

2013

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A general, enantioselective synthesis of 1-azabicyclo[m.n.0]alkane ring systems

Tetrahedron letters, 2013-03, Vol.54 (13), p.1645-1648

2013

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Microwave-assisted, one-pot reaction of 7-azaindoles and aldehydes: a facile route to novel di-7-azaindolylmethanes

Tetrahedron letters, 2014-01, Vol.55 (1), p.169-173

2014

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Non-Invasive Glutamine PET Reflects Pharmacological Inhibition of BRAFV600E In Vivo

Molecular imaging and biology, 2017-06, Vol.19 (3), p.421-428

2017

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Synthetic adjuvants for vaccine formulations: Evaluation of new phytol derivatives in induction and persistence of specific immune response

Cellular immunology, 2011, Vol.271 (2), p.308-318

2011

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Targeting glutamine metabolism through inhibition of GLS1 enhances therapeutic efficacy of EGFR-targeted antibodies in colorectal cancer

The Journal of nuclear medicine (1978), 2018-02, Vol.59 (2), p.354

2018

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Beta Cell Imaging-From Pre-Clinical Validation to First in Man Testing

Combined blockade of EGFR and glutamine metabolism in preclinical models of colorectal cancer

Skeletal muscle metabolic responses to physical activity are muscle type specific in a rat model of chronic kidney disease

Substituted indoles as selective protease activated receptor 4 (PAR-4) antagonists: Discovery and SAR of ML354

Synthesis of indole derived protease-activated receptor 4 antagonists and characterization in human platelets

Pharmacological blockade of ASCT2-dependent glutamine transport leads to antitumor efficacy in preclinical models

General Access to Chiral N-Alkyl Terminal Aziridines via Organocatalysis

Mutant KRAS Exosomes Alter the Metabolic State of Recipient Colonic Epithelial Cells

Hybrid 18F-Fluoroethyltyrosine PET and MRI with Perfusion to Distinguish Disease Progression from Treatment-Related Change in Malignant Brain Tumors: The Quest to Beat the Toughest Cases

Hybrid 18 F-Fluoroethyltyrosine PET and MRI with Perfusion to Distinguish Disease Progression from Treatment-Related Change in Malignant Brain Tumors: The Quest to Beat the Toughest Cases

2-Amino-4-bis(aryloxybenzyl)aminobutanoic acids: A novel scaffold for inhibition of ASCT2-mediated glutamine transport

Highly Diastereoselective and General Synthesis of Primary β-Fluoroamines

Positive allosteric modulators (PAMs) of the group II metabotropic glutamate receptors: Design, synthesis, and evaluation as ex-vivo tool compounds

Automated radiosynthesis of 5-[11C]l-glutamine, an important tracer for glutamine utilization

2-Substituted Nγ-glutamylanilides as novel probes of ASCT2 with improved potency

Optimized Translocator Protein Ligand for Optical Molecular Imaging and Screening

New structure–activity relationships of N-acetamide substituted pyrazolopyrimidines as pharmacological ligands of TSPO

Further exploration of an N-aryl phenoxyethoxy pyridinone-based series of mGlu3 NAMs: Challenging SAR, enantiospecific activity and in vivo efficacy

Total Synthesis of Stemaphylline N-Oxide and Related C9a-Epimeric Analogues

A general, enantioselective synthesis of 1-azabicyclo[m.n.0]alkane ring systems

Microwave-assisted, one-pot reaction of 7-azaindoles and aldehydes: a facile route to novel di-7-azaindolylmethanes

The Discovery and Characterization of ML218: A Novel, Centrally Active T-Type Calcium Channel Inhibitor with Robust Effects in STN Neurons and in a Rodent Model of Parkinson’s Disease

Non-Invasive Glutamine PET Reflects Pharmacological Inhibition of BRAFV600E In Vivo

Synthetic adjuvants for vaccine formulations: Evaluation of new phytol derivatives in induction and persistence of specific immune response

Targeting glutamine metabolism through inhibition of GLS1 enhances therapeutic efficacy of EGFR-targeted antibodies in colorectal cancer

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