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Liver X receptors link lipid metabolism and inflammation

FEBS letters, 2017-10, Vol.591 (19), p.2978-2991

Schulman, Ira G.

2017

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Phenotypic polarization of macrophages in atherosclerosis

Arteriosclerosis, thrombosis, and vascular biology, 2013-06, Vol.33 (6), p.1120

2013

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The Transcription Factor STAT6 Mediates Direct Repression of Inflammatory Enhancers and Limits Activation of Alternatively Polarized Macrophages

Immunity (Cambridge, Mass.), 2018-01, Vol.48 (1), p.75-90.e6

2018

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Apoptotic cells trigger a membrane-initiated pathway to increase ABCA1

The Journal of clinical investigation, 2015-07, Vol.125 (7), p.2748-2758

2015

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Activation of murine pre-proglucagon-producing neurons reduces food intake and body weight

The Journal of clinical investigation, 2017-03, Vol.127 (3), p.1031-1045

2017

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Macrophage-independent regulation of reverse cholesterol transport by liver X receptors

Arteriosclerosis, thrombosis, and vascular biology, 2014-08, Vol.34 (8), p.1650

2014

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Liver X receptors and liver physiology

Biochimica et biophysica acta. Molecular basis of disease, 2021-06, Vol.1867 (6), p.166121-166121, Article 166121

2021

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Non-redundant roles for LXRα and LXRβ in atherosclerosis susceptibility in low density lipoprotein receptor knockout mice[S]

Journal of lipid research, 2010-05, Vol.51 (5), p.900-906

2010

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Macrophage liver X receptor is required for antiatherogenic activity of LXR agonists

Arteriosclerosis, thrombosis, and vascular biology, 2005-01, Vol.25 (1), p.135

2005

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Differential Regulation of Gene Expression by LXRs in Response to Macrophage Cholesterol Loading

Molecular endocrinology (Baltimore, Md.), 2013-07, Vol.27 (7), p.1036-1047

2013

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Nuclear receptors as drug targets for metabolic disease

Advanced drug delivery reviews, 2010-10, Vol.62 (13), p.1307-1315

Schulman, Ira G.

2010

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In vitro transcriptomic prediction of hepatotoxicity for early drug discovery

Journal of theoretical biology, 2011-12, Vol.290, p.27-36

2011

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Identification of Macrophage Liver X Receptors as Inhibitors of Atherosclerosis

Proceedings of the National Academy of Sciences - PNAS, 2002-09, Vol.99 (18), p.11896-11901

2002

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Promoter-Specific Roles for Liver X Receptor/Corepressor Complexes in the Regulation of ABCA1 and SREBP1 Gene Expression

Molecular and Cellular Biology, 2003-08, Vol.23 (16), p.5780-5789

2003

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Farnesoid X Receptor Regulates Bile Acid-Amino Acid Conjugation

The Journal of biological chemistry, 2003-07, Vol.278 (30), p.27703-27711

2003

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Regulation of Complement C3 Expression by the Bile Acid Receptor FXR

The Journal of biological chemistry, 2005-03, Vol.280 (9), p.7427-7434

2005

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Liver LXRα expression is crucial for whole body cholesterol homeostasis and reverse cholesterol transport in mice

The Journal of clinical investigation, 2012-05, Vol.122 (5), p.1688-1699

2012

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Antihyperlipidemic Activity of Gut-Restricted LXR Inverse Agonists

ACS chemical biology, 2022-05, Vol.17 (5), p.1143-1154

2022

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Regulation of Cholesterol Homeostasis and Lipid Metabolism in Skeletal Muscle by Liver X Receptors

The Journal of biological chemistry, 2002-10, Vol.277 (43), p.40722-40728

2002

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Deficiency of Dab2 (Disabled Homolog 2) in Myeloid Cells Exacerbates Inflammation in Liver and Atherosclerotic Plaques in LDLR (Low-Density Lipoprotein Receptor)-Null Mice-Brief Report

Arteriosclerosis, thrombosis, and vascular biology, 2018-05, Vol.38 (5), p.1020

2018

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Errα and Gabpa/b Specify PGC-1α-Dependent Oxidative Phosphorylation Gene Expression That Is Altered in Diabetic Muscle

Proceedings of the National Academy of Sciences - PNAS, 2004-04, Vol.101 (17), p.6570-6575

2004

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Liver X receptors and atherosclerosis: it is not all cholesterol

Arteriosclerosis, thrombosis, and vascular biology, 2014-02, Vol.34 (2), p.242

2014

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Activation of specific RXR heterodimers by an antagonist of RXR homodimers

Nature (London), 1996-10, Vol.383 (6599), p.450-453

1996

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Structural analysis identifies an escape route from the adverse lipogenic effects of liver X receptor ligands

Communications biology, 2019-11, Vol.2 (1), p.431-431, Article 431

2019

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Regulation of PPARγ Coactivator 1α (PGC-1α) Signaling by an Estrogen-Related Receptor α (ERRα) Ligand

Proceedings of the National Academy of Sciences - PNAS, 2004-06, Vol.101 (24), p.8912-8917

2004

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Liver X Receptors
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Liver X receptors link lipid metabolism and inflammation

Phenotypic polarization of macrophages in atherosclerosis

The Transcription Factor STAT6 Mediates Direct Repression of Inflammatory Enhancers and Limits Activation of Alternatively Polarized Macrophages

Apoptotic cells trigger a membrane-initiated pathway to increase ABCA1

Activation of murine pre-proglucagon-producing neurons reduces food intake and body weight

Macrophage-independent regulation of reverse cholesterol transport by liver X receptors

Liver X receptors and liver physiology

Non-redundant roles for LXRα and LXRβ in atherosclerosis susceptibility in low density lipoprotein receptor knockout mice[S]

Macrophage liver X receptor is required for antiatherogenic activity of LXR agonists

Differential Regulation of Gene Expression by LXRs in Response to Macrophage Cholesterol Loading

Nuclear receptors as drug targets for metabolic disease

In vitro transcriptomic prediction of hepatotoxicity for early drug discovery

Identification of Macrophage Liver X Receptors as Inhibitors of Atherosclerosis

Promoter-Specific Roles for Liver X Receptor/Corepressor Complexes in the Regulation of ABCA1 and SREBP1 Gene Expression

Farnesoid X Receptor Regulates Bile Acid-Amino Acid Conjugation

Regulation of Complement C3 Expression by the Bile Acid Receptor FXR

Liver LXRα expression is crucial for whole body cholesterol homeostasis and reverse cholesterol transport in mice

Antihyperlipidemic Activity of Gut-Restricted LXR Inverse Agonists

Regulation of Cholesterol Homeostasis and Lipid Metabolism in Skeletal Muscle by Liver X Receptors

Deficiency of Dab2 (Disabled Homolog 2) in Myeloid Cells Exacerbates Inflammation in Liver and Atherosclerotic Plaques in LDLR (Low-Density Lipoprotein Receptor)-Null Mice-Brief Report

Errα and Gabpa/b Specify PGC-1α-Dependent Oxidative Phosphorylation Gene Expression That Is Altered in Diabetic Muscle

Liver X receptors and atherosclerosis: it is not all cholesterol

Activation of specific RXR heterodimers by an antagonist of RXR homodimers

Structural analysis identifies an escape route from the adverse lipogenic effects of liver X receptor ligands

Regulation of PPARγ Coactivator 1α (PGC-1α) Signaling by an Estrogen-Related Receptor α (ERRα) Ligand

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