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Translational PK/PD and the first-in-human dose selection of a PD1/IL15: an engineered recombinant targeted cytokine for cancer immunotherapy

Frontiers in pharmacology, 2024-06, Vol.15, p.1380000

2024

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Hyperactive Ras in developmental disorders and cancer

Nature reviews. Cancer, 2007-04, Vol.7 (4), p.295-308

2007

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Suppression of leukemia development caused by PTEN loss

Proceedings of the National Academy of Sciences - PNAS, 2011-01, Vol.108 (4), p.1409-1414

2011

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Functional analysis of leukemia-associated PTPN11 mutations in primary hematopoietic cells

Blood, 2005-07, Vol.106 (1), p.311-317

2005

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Biochemical and Functional Characterization of Germ Line KRAS Mutations

Molecular and Cellular Biology, 2007-11, Vol.27 (22), p.7765-7770

2007

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714 PD1 x TGFβR2 bispecifics selectively block TGFβR2 on PD1-positive T cells, promote T cell activation, and elicit an anti-tumor response in solid tumors

Journal for immunotherapy of cancer, 2020-11, Vol.8 (Suppl 3), p.A756-A756

2020

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Germline Mutations in Components of the Ras Signaling Pathway in Noonan Syndrome and Related Disorders

Cell cycle (Georgetown, Tex.), 2006-08, Vol.5 (15), p.1607-1611

2006

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Deregulated Ras signaling in developmental disorders: new tricks for an old dog

Current opinion in genetics & development, 2007-02, Vol.17 (1), p.15-22

2007

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Targeting the MYC and PI3K pathways eliminates leukemia-initiating cells in T-cell acute lymphoblastic leukemia

Cancer research (Chicago, Ill.), 2014-12, Vol.74 (23), p.7048-7059

2014

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Germline KRAS mutations cause Noonan syndrome

Nature genetics, 2006-03, Vol.38 (3), p.331-336

2006

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Regulatory T Cell Selective IL-2-Fc Fusion Proteins for the Treatment of Autoimmune Diseases

Blood, 2018-11, Vol.132 (Supplement 1), p.3709-3709

2018

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Mutations in PTPN11 implicate the SHP-2 phosphatase in leukemogenesis

Blood, 2004-03, Vol.103 (6), p.2325-2331

2004

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Abstract 5565: Potency-reduced IL15/IL15Rα heterodimeric Fc-fusions display enhanced in vivo activity through increased exposure

Cancer research (Chicago, Ill.), 2018-07, Vol.78 (13_Supplement), p.5565-5565

2018

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Abstract 3633: Anti-SSTR2 × anti-CD3 bispecific antibody induces potent killing of human tumor cells in vitro and in mice, and stimulates target-dependent T cell activation in monkeys: A potential immunotherapy for neuroendocrine tumors

Cancer research (Chicago, Ill.), 2017-07, Vol.77 (13_Supplement), p.3633-3633

2017

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Abstract 1639: Combination of PD1 blockade and T cell costimulation by bispecific antibodies promotes human T cell activation and proliferation

Cancer research (Chicago, Ill.), 2017-07, Vol.77 (13_Supplement), p.1639-1639

2017

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Abstract 2080: LAG3-targeted IL15/IL15Rα-Fc (LAG3 x IL15) fusion proteins for preferential TIL expansion

Cancer research (Chicago, Ill.), 2022-06, Vol.82 (12_Supplement), p.2080-2080

2022

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Abstract B12: Co-inhibition of PI3K and Myc pathways is synthetic lethal to PTEN null T-ALL leukemia-initiating cells

Molecular cancer therapeutics, 2013-05, Vol.12 (5_Supplement), p.B12-B12

2013

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Tuning T Cell Affinity Improves Efficacy and Safety of Anti-CD38 × Anti-CD3 Bispecific Antibodies in Monkeys - a Potential Therapy for Multiple Myeloma

Blood, 2015-12, Vol.126 (23), p.1798-1798

2015

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Hyperactive Ras in developmental disorders and cancer

Nature reviews. Cancer, 2007-07, Vol.7 (7)

2007

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Erratum: Hyperactive Ras in developmental disorders and cancer

Nature reviews. Cancer, 2007-07, Vol.7 (7), p.564-564

2007

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Mutation analysis in Costello syndrome: functional and structural characterization of the HRAS p.Lys117Arg mutation

Human mutation, 2008-02, Vol.29 (2), p.232-239

2008

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De novo HRAS and KRAS mutations in two siblings with short stature and neuro-cardio-facio-cutaneous features

Journal of medical genetics, 2007-07, Vol.44 (7), p.e84-e84

2007

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Biochemical and Functional Analysis of Germline KRAS Mutations That Cause Disorders of the Noonan Syndrome Spectrum

Blood, 2006-11, Vol.108 (11), p.1431-1431

2006

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Biochemical and functional analysis of Ras pathway mutations in myeloid leukemia and developmental disorders

Schubbert, Suzanne

2007

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ProQuest

Functional Analysis of Leukemia-Associated PTPN11 Mutations in Primary Hematopoietic Cells

Blood, 2004-11, Vol.104 (11), p.2423-2423

2004

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Translational PK/PD and the first-in-human dose selection of a PD1/IL15: an engineered recombinant targeted cytokine for cancer immunotherapy

Hyperactive Ras in developmental disorders and cancer

Suppression of leukemia development caused by PTEN loss

Functional analysis of leukemia-associated PTPN11 mutations in primary hematopoietic cells

Biochemical and Functional Characterization of Germ Line KRAS Mutations

714 PD1 x TGFβR2 bispecifics selectively block TGFβR2 on PD1-positive T cells, promote T cell activation, and elicit an anti-tumor response in solid tumors

Germline Mutations in Components of the Ras Signaling Pathway in Noonan Syndrome and Related Disorders

Deregulated Ras signaling in developmental disorders: new tricks for an old dog

Targeting the MYC and PI3K pathways eliminates leukemia-initiating cells in T-cell acute lymphoblastic leukemia

Germline KRAS mutations cause Noonan syndrome

Regulatory T Cell Selective IL-2-Fc Fusion Proteins for the Treatment of Autoimmune Diseases

Mutations in PTPN11 implicate the SHP-2 phosphatase in leukemogenesis

Abstract 5565: Potency-reduced IL15/IL15Rα heterodimeric Fc-fusions display enhanced in vivo activity through increased exposure

Abstract 3633: Anti-SSTR2 × anti-CD3 bispecific antibody induces potent killing of human tumor cells in vitro and in mice, and stimulates target-dependent T cell activation in monkeys: A potential immunotherapy for neuroendocrine tumors

Abstract 1639: Combination of PD1 blockade and T cell costimulation by bispecific antibodies promotes human T cell activation and proliferation

Abstract 2080: LAG3-targeted IL15/IL15Rα-Fc (LAG3 x IL15) fusion proteins for preferential TIL expansion

Abstract B12: Co-inhibition of PI3K and Myc pathways is synthetic lethal to PTEN null T-ALL leukemia-initiating cells

Tuning T Cell Affinity Improves Efficacy and Safety of Anti-CD38 × Anti-CD3 Bispecific Antibodies in Monkeys - a Potential Therapy for Multiple Myeloma

Hyperactive Ras in developmental disorders and cancer

Erratum: Hyperactive Ras in developmental disorders and cancer

Mutation analysis in Costello syndrome: functional and structural characterization of the HRAS p.Lys117Arg mutation

De novo HRAS and KRAS mutations in two siblings with short stature and neuro-cardio-facio-cutaneous features

Biochemical and Functional Analysis of Germline KRAS Mutations That Cause Disorders of the Noonan Syndrome Spectrum

Biochemical and functional analysis of Ras pathway mutations in myeloid leukemia and developmental disorders

Functional Analysis of Leukemia-Associated PTPN11 Mutations in Primary Hematopoietic Cells

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