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What does systems biology mean for drug development?

Current medicinal chemistry, 2008-06, Vol.15 (15), p.1520-1528

2008

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NMDA receptors are not alone: dynamic regulation of NMDA receptor structure and function by neuregulins and transient cholesterol-rich membrane domains leads to disease-specific nuances of glutamate-signalling

Current topics in medicinal chemistry, 2006-04, Vol.6 (7), p.663-686

2006

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Poly (ADP-Ribose) Polymerase-1 (PARP1) Deficiency and Pharmacological Inhibition by Pirenzepine Protects From Cisplatin-Induced Ototoxicity Without Affecting Antitumor Efficacy

Frontiers in cellular neuroscience, 2019-09, Vol.13, p.406-406

2019

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The suitability of BV2 cells as alternative model system for primary microglia cultures or for animal experiments examining brain inflammation

ALTEX, alternatives to animal experimentation, 2009, Vol.26 (2), p.83-94

2009

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The nonerythropoietic asialoerythropoietin protects against neonatal hypoxia‐ischemia as potently as erythropoietin

Journal of neurochemistry, 2004-11, Vol.91 (4), p.900-910

2004

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Arylpiperazine-mediated activation of Akt protects SH-SY5Y neuroblastoma cells from 6-hydroxydopamine-induced apoptotic and autophagic death

Neuropharmacology, 2013-09, Vol.72, p.224-235

2013

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Protein Expression Profiling in Esophageal Adenocarcinoma Patients Indicates Association of Heat-Shock Protein 27 Expression and Chemotherapy Response

Clinical cancer research, 2008-12, Vol.14 (24), p.8279-8287

2008

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Autocatalytic cleavage of Clostridium difficile toxin B

Nature, 2007-03, Vol.446 (7134), p.415-419

2007

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BACE-1 is expressed in the blood–brain barrier endothelium and is upregulated in a murine model of Alzheimer’s disease

Journal of cerebral blood flow and metabolism, 2016-07, Vol.36 (7), p.1281-1294

2016

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Putative adverse outcome pathways relevant to neurotoxicity

Critical reviews in toxicology, 2015-01, Vol.45 (1), p.83-91

2015

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The dynamics of the LPS triggered inflammatory response of murine microglia under different culture and in vivo conditions

Journal of neuroimmunology, 2006-11, Vol.180 (1), p.71-87

2006

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Allosterically potentiating ligands of nicotinic receptors as a treatment strategy for Alzheimer’s disease

Behavioural brain research, 2000-08, Vol.113 (1), p.199-206

2000

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Nonenzymatic posttranslational protein modifications in ageing

Experimental gerontology, 2008-04, Vol.43 (4), p.247-257

2008

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Expression and Prognostic Relevance of Annexin A3 in Prostate Cancer

European urology, 2008-12, Vol.54 (6), p.1314-1323

2008

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Annexin A3 in Urine: A Highly Specific Noninvasive Marker for Prostate Cancer Early Detection

The Journal of urology, 2009, Vol.181 (1), p.343-353

2009

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Immunoproteomic Identification and Serological Responses to Novel Chlamydia pneumoniae Antigens That Are Associated with Persistent C. pneumoniae Infections

The Journal of immunology (1950), 2008-04, Vol.180 (8), p.5490-5498

2008

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The inflammatory transcriptome of reactive murine astrocytes and implications for their innate immune function

Journal of neurochemistry, 2006-02, Vol.96 (3), p.893-907

2006

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What does it need to be a biomarker? Relationships between resolution, differential quantification and statistical validation of protein surrogate biomarkers

Electrophoresis, 2007-06, Vol.28 (12), p.1970-1979

2007

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Systemic administration of neuregulin‐1β1 protects dopaminergic neurons in a mouse model of Parkinson’s disease

Journal of neurochemistry, 2011-06, Vol.117 (6), p.1066-1074

2011

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Stem cells in head and neck squamous cell carcinoma

British journal of oral & maxillofacial surgery, 2011-10, Vol.49 (7), p.503-506

2011

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Neuregulin-1 receptor tyrosine kinase ErbB4 is upregulated in midbrain dopaminergic neurons in Parkinson disease

Neuroscience letters, 2012-12, Vol.531 (2), p.209-214

2012

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Oxaloacetate decarboxylase FAHD1 – a new regulator of mitochondrial function and senescence

Mechanisms of ageing and development, 2019-01, Vol.177, p.22-29

2019

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Proteomic surrogate biomarkers for in vitro testing of embryotoxicity: Quantitative differential investigation of ESC models

Toxicology letters, 2009-09, Vol.189, p.S31-S31

Schrattenholz, Andre

2009

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Protein Biomarkers for in Vitro Testing of Embryotoxicity

Journal of proteome research, 2010-11, Vol.9 (11), p.5727-5738

2010

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Synchronization of posttranslational modifications during aging

Annals of the New York Academy of Sciences, 2010-06, Vol.1197 (1), p.118-128

2010

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What does systems biology mean for drug development?

NMDA receptors are not alone: dynamic regulation of NMDA receptor structure and function by neuregulins and transient cholesterol-rich membrane domains leads to disease-specific nuances of glutamate-signalling

Poly (ADP-Ribose) Polymerase-1 (PARP1) Deficiency and Pharmacological Inhibition by Pirenzepine Protects From Cisplatin-Induced Ototoxicity Without Affecting Antitumor Efficacy

The suitability of BV2 cells as alternative model system for primary microglia cultures or for animal experiments examining brain inflammation

The nonerythropoietic asialoerythropoietin protects against neonatal hypoxia‐ischemia as potently as erythropoietin

Arylpiperazine-mediated activation of Akt protects SH-SY5Y neuroblastoma cells from 6-hydroxydopamine-induced apoptotic and autophagic death

Protein Expression Profiling in Esophageal Adenocarcinoma Patients Indicates Association of Heat-Shock Protein 27 Expression and Chemotherapy Response

Autocatalytic cleavage of Clostridium difficile toxin B

BACE-1 is expressed in the blood–brain barrier endothelium and is upregulated in a murine model of Alzheimer’s disease

Putative adverse outcome pathways relevant to neurotoxicity

The dynamics of the LPS triggered inflammatory response of murine microglia under different culture and in vivo conditions

Allosterically potentiating ligands of nicotinic receptors as a treatment strategy for Alzheimer’s disease

Nonenzymatic posttranslational protein modifications in ageing

Expression and Prognostic Relevance of Annexin A3 in Prostate Cancer

Annexin A3 in Urine: A Highly Specific Noninvasive Marker for Prostate Cancer Early Detection

Immunoproteomic Identification and Serological Responses to Novel Chlamydia pneumoniae Antigens That Are Associated with Persistent C. pneumoniae Infections

The inflammatory transcriptome of reactive murine astrocytes and implications for their innate immune function

What does it need to be a biomarker? Relationships between resolution, differential quantification and statistical validation of protein surrogate biomarkers

Systemic administration of neuregulin‐1β1 protects dopaminergic neurons in a mouse model of Parkinson’s disease

Stem cells in head and neck squamous cell carcinoma

Neuregulin-1 receptor tyrosine kinase ErbB4 is upregulated in midbrain dopaminergic neurons in Parkinson disease

Oxaloacetate decarboxylase FAHD1 – a new regulator of mitochondrial function and senescence

Proteomic surrogate biomarkers for in vitro testing of embryotoxicity: Quantitative differential investigation of ESC models

Protein Biomarkers for in Vitro Testing of Embryotoxicity

Synchronization of posttranslational modifications during aging

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