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Angiotensin II receptor subtypes in renal cortex of rats and rhesus monkeys

American journal of physiology. Renal physiology, 1991-09, Vol.261 (3), p.512-F518

1991

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Potent, orally active imidazo[4,5-b]pyridine-based angiotensin II receptor antagonists

Journal of medicinal chemistry, 1991-09, Vol.34 (9), p.2919-2922

1991

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In vitro and in vivo evaluation of dihydropyrimidinone C-5 amides as potent and selective alpha(1A) receptor antagonists for the treatment of benign prostatic hyperplasia

Journal of medicinal chemistry, 2000-07, Vol.43 (14), p.2703-2718

2000

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Discovery of L-162,313: a nonpeptide that mimics the biological actions of angiotensin II

American journal of physiology. Regulatory, integrative and comparative physiology, 1995-03, Vol.268 (3), p.820-R823

1995

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Synthesis and use of 3-amino-4-phenyl-2-piperidones and 4-amino-2-benzazepin-3-ones as conformationally restricted phenylalanine isosteres in renin inhibitors

Journal of medicinal chemistry, 1992-03, Vol.35 (5), p.833-846

1992

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Design and synthesis of novel alpha(1)(a) adrenoceptor-selective antagonists. 1. Structure-activity relationship in dihydropyrimidinones

Journal of medicinal chemistry, 1999-11, Vol.42 (23), p.4764-4777

1999

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Renin inhibitors. Syntheses of subnanomolar, competitive, transition-state analog inhibitors containing a novel analog of statine

Journal of medicinal chemistry, 1985-12, Vol.28 (12), p.1779-1790

1985

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Highly potent, orally active diester macrocyclic human renin inhibitors

Journal of medicinal chemistry, 1992-10, Vol.35 (21), p.3755-3773

1992

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Biotransformation of 5-chloro-3-phenylthioindole-2-carboxamide (L-734,005) in rhesus monkeys and rat liver microsomes to a potent HIV-1 reverse transcriptase inhibitor

Drug metabolism and disposition, 1993-07, Vol.21 (4), p.598

1993

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Renin inhibitors containing C-termini derived from mercaptoheterocycles

Journal of medicinal chemistry, 1992-05, Vol.35 (11), p.2103-2112

1992

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Design and synthesis of novel alpha(1)(a) adrenoceptor-selective antagonists. 2. Approaches to eliminate opioid agonist metabolites via modification of linker and 4-methoxycarbonyl-4-phenylpiperidine moiety

Journal of medicinal chemistry, 1999-11, Vol.42 (23), p.4778-4793

1999

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L-368,899, a potent orally active oxytocin antagonist for potential use in preterm labor

Drug development research, 1993-11, Vol.30 (3), p.129-142

1993

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Inhibitors of human renin with C-termini derived from amides and esters of .alpha.-mercaptoalkanoic acids

Journal of medicinal chemistry, 1992-07, Vol.35 (15), p.2772-2781

1992

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The character of the atrial natriuretic response: pressure and volume effects

Journal of hypertension. Supplement, 1986-06, Vol.4 (2), p.S17-S24

1986

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Acute hypotensive responses to peptide inhibitors of renin in conscious monkeys: an effect on blood pressure independent of plasma renin inhibition

Journal of hypertension, 1990-03, Vol.8 (3), p.251-259

1990

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In Vivo Pharmacology of L-159,913, A New Highly Potent and Selective Nonpeptide Angiotensin II Receptor Antagonist

Clinical and experimental hypertension (1993), 1995, Vol.17 (6), p.931-953

1995

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Nonpeptide angiotensin II antagonists derived from 4H-1,2,4-triazoles and 3H-imidazo[1,2-b][1,2,4]triazoles

Journal of medicinal chemistry, 1993-03, Vol.36 (5), p.591-609

1993

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In vivo pharmacology of a novel AT1 selective angiotensin II receptor antagonist, MK-996

American journal of hypertension, 1995-01, Vol.8 (1), p.58-66

1995

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An orally active prostaglandin analog with renal vasodilatory activity in the dog

The Journal of pharmacology and experimental therapeutics, 1982-07, Vol.222 (1), p.152

1982

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Design and synthesis of N-alkylated saccharins as selective alpha-1a adrenergic receptor antagonists

Bioorganic & medicinal chemistry letters, 1998-09, Vol.8 (18), p.2467-2472

1998

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Novel renin inhibitors containing the amino acid statine

Nature (London), 1983-05, Vol.303 (5912), p.81-84

1983

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Statine-Containing Renin Inhibitor: Dissociation of Blood Pressure Lowering and Renin Inhibition in Sodium-Deficient Dogs

Hypertension (Dallas, Tex. 1979), 1984-03, Vol.6 (2 Suppl I), p.I-111-I-118

1984

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Renin inhibitors containing conformationally restricted P1-P1' dipeptide mimetics

Journal of medicinal chemistry, 1991-03, Vol.34 (3), p.887-900

1991

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Quinazolinone Biphenyl Acylsulfonamides: A potent new class of angiotensin-II receptor antagonists

Bioorganic & medicinal chemistry letters, 1994-01, Vol.4 (1), p.75-80

1994

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A rapid bioassay for the determination of non-nucleoside HIV-1 reverse transcriptase inhibitor plasma levels

Life sciences (1973), 1993, Vol.52 (3), p.243-249

1993

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Angiotensin II receptor subtypes in renal cortex of rats and rhesus monkeys

Potent, orally active imidazo[4,5-b]pyridine-based angiotensin II receptor antagonists

In vitro and in vivo evaluation of dihydropyrimidinone C-5 amides as potent and selective alpha(1A) receptor antagonists for the treatment of benign prostatic hyperplasia

Discovery of L-162,313: a nonpeptide that mimics the biological actions of angiotensin II

Synthesis and use of 3-amino-4-phenyl-2-piperidones and 4-amino-2-benzazepin-3-ones as conformationally restricted phenylalanine isosteres in renin inhibitors

Design and synthesis of novel alpha(1)(a) adrenoceptor-selective antagonists. 1. Structure-activity relationship in dihydropyrimidinones

Renin inhibitors. Syntheses of subnanomolar, competitive, transition-state analog inhibitors containing a novel analog of statine

Highly potent, orally active diester macrocyclic human renin inhibitors

Biotransformation of 5-chloro-3-phenylthioindole-2-carboxamide (L-734,005) in rhesus monkeys and rat liver microsomes to a potent HIV-1 reverse transcriptase inhibitor

Renin inhibitors containing C-termini derived from mercaptoheterocycles

Design and synthesis of novel alpha(1)(a) adrenoceptor-selective antagonists. 2. Approaches to eliminate opioid agonist metabolites via modification of linker and 4-methoxycarbonyl-4-phenylpiperidine moiety

L-368,899, a potent orally active oxytocin antagonist for potential use in preterm labor

Inhibitors of human renin with C-termini derived from amides and esters of .alpha.-mercaptoalkanoic acids

The character of the atrial natriuretic response: pressure and volume effects

Acute hypotensive responses to peptide inhibitors of renin in conscious monkeys: an effect on blood pressure independent of plasma renin inhibition

In Vivo Pharmacology of L-159,913, A New Highly Potent and Selective Nonpeptide Angiotensin II Receptor Antagonist

Nonpeptide angiotensin II antagonists derived from 4H-1,2,4-triazoles and 3H-imidazo[1,2-b][1,2,4]triazoles

In vivo pharmacology of a novel AT1 selective angiotensin II receptor antagonist, MK-996

An orally active prostaglandin analog with renal vasodilatory activity in the dog

Design and synthesis of N-alkylated saccharins as selective alpha-1a adrenergic receptor antagonists

Novel renin inhibitors containing the amino acid statine

Statine-Containing Renin Inhibitor: Dissociation of Blood Pressure Lowering and Renin Inhibition in Sodium-Deficient Dogs

Renin inhibitors containing conformationally restricted P1-P1' dipeptide mimetics

Quinazolinone Biphenyl Acylsulfonamides: A potent new class of angiotensin-II receptor antagonists

A rapid bioassay for the determination of non-nucleoside HIV-1 reverse transcriptase inhibitor plasma levels

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