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Nonlinear Mixed‐Effects Model Development and Simulation Using nlmixr and Related R Open‐Source Packages

CPT: pharmacometrics and systems pharmacology, 2019-09, Vol.8 (9), p.621-633

2019

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AUC-guided dosing of tacrolimus prevents progressive systemic overexposure in renal transplant recipients

Kidney international, 2005-06, Vol.67 (6), p.2440-2447

2005

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Population pharmacokinetics and covariate analysis of Sym004, an antibody mixture against the epidermal growth factor receptor, in subjects with metastatic colorectal cancer and other solid tumors

Journal of pharmacokinetics and pharmacodynamics, 2020-02, Vol.47 (1), p.5-18

2020

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R and nlmixr as a gateway between statistics and pharmacometrics

CPT: pharmacometrics and systems pharmacology, 2021-04, Vol.10 (4), p.283-285

2021

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A phase I study of recombinant human C1 inhibitor in asymptomatic patients with hereditary angioedema

Journal of Allergy and Clinical Immunology, 2005-10, Vol.116 (4), p.876-883

2005

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Performance of the SAEM and FOCEI Algorithms in the Open‐Source, Nonlinear Mixed Effect Modeling Tool nlmixr

CPT: pharmacometrics and systems pharmacology, 2019-12, Vol.8 (12), p.923-930

2019

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Pharmacokinetic–pharmacodynamic relationships of central nervous system effects of scopolamine in healthy subjects

British journal of clinical pharmacology, 2011-06, Vol.71 (6), p.886-898

2011

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Effect of garlic powder on C-reactive protein and plasma lipids in overweight and smoking subjects

The American journal of clinical nutrition, 2006-12, Vol.84 (6), p.1324-1329

2006

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Pharmacokinetics of oral fumarates in healthy subjects

British journal of clinical pharmacology, 2004-10, Vol.58 (4), p.429-432

2004

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Cognitive performance and serotonergic function in users of ecstasy

Psychopharmacologia, 2001-01, Vol.153 (2), p.196-202

2001

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Population Pharmacokinetics of Adjunctive Lacosamide in Pediatric Patients With Epilepsy

Journal of clinical pharmacology, 2019-04, Vol.59 (4), p.541-547

2019

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Intraocular penetration and systemic absorption after topical application of dexamethasone disodium phosphate

Ophthalmology (Rochester, Minn.), 2002-10, Vol.109 (10), p.1887-1891

2002

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Central nervous system effects of alcohol at a pseudo‐steady‐state concentration using alcohol clamping in healthy volunteers

British journal of clinical pharmacology, 2009-10, Vol.68 (4), p.524-534

2009

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Autonomic Nervous System Function in Chronic Exogenous Subclinical Thyrotoxicosis and the Effect of Restoring Euthyroidism

The journal of clinical endocrinology and metabolism, 2008-07, Vol.93 (7), p.2835-2841

2008

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Brivaracetam Population Pharmacokinetics and Exposure-Response Modeling in Adult Subjects With Partial-Onset Seizures

Journal of clinical pharmacology, 2016-12, Vol.56 (12), p.1591-1602

2016

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Modeling and simulation for the evaluation of dose adaptation rules of intravenous lacosamide in children

Epilepsy research, 2019-01, Vol.149, p.13-16

2019

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Brivaracetam population pharmacokinetics in children with epilepsy aged 1 month to 16 years

European journal of clinical pharmacology, 2017-06, Vol.73 (6), p.727-733

2017

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High concentration of dexamethasone in aqueous and vitreous after subconjunctival injection

American journal of ophthalmology, 1999-08, Vol.128 (2), p.192-197

1999

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Brivaracetam exposure-response predictions in pediatric patients from age 1 month: Extrapolation of levetiracetam adult-pediatric scaling to brivaracetam

Epilepsy research, 2024-05, Vol.202, p.107332-107332, Article 107332

2024

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Extrapolation of a Brivaracetam Exposure–Response Model from Adults to Children with Focal Seizures

Clinical pharmacokinetics, 2018-07, Vol.57 (7), p.843-854

2018

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A comparative study of two methods for attaining constant alcohol levels

British journal of clinical pharmacology, 2008-11, Vol.66 (5), p.674-681

2008

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Circadian Rhythm of Plasma Leptin Levels in Upper and Lower Body Obese Women: Influence of Body Fat Distribution and Weight Loss

The journal of clinical endocrinology and metabolism, 1998-05, Vol.83 (5), p.1706-1712

1998

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Model‐based comparisons of post‐treatment free IgE and FEV1 between omalizumab asthma dosing tables in the United States and European Union

British journal of clinical pharmacology, 2024-08

2024

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Dexamethasone concentration in the subretinal fluid after a subconjunctival injection, a peribulbar injection, or an oral dose

Ophthalmology (Rochester, Minn.), 2000-10, Vol.107 (10), p.1932-1938

2000

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A compartmental pharmacokinetic model of cyclosporin and its predictive performance after Bayesian estimation in kidney and simultaneous pancreas–kidney transplant recipients

Nephrology, dialysis, transplantation, 2003-06, Vol.18 (6), p.1201-1208

2003

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Nonlinear Mixed‐Effects Model Development and Simulation Using nlmixr and Related R Open‐Source Packages

AUC-guided dosing of tacrolimus prevents progressive systemic overexposure in renal transplant recipients

Population pharmacokinetics and covariate analysis of Sym004, an antibody mixture against the epidermal growth factor receptor, in subjects with metastatic colorectal cancer and other solid tumors

R and nlmixr as a gateway between statistics and pharmacometrics

A phase I study of recombinant human C1 inhibitor in asymptomatic patients with hereditary angioedema

Performance of the SAEM and FOCEI Algorithms in the Open‐Source, Nonlinear Mixed Effect Modeling Tool nlmixr

Pharmacokinetic–pharmacodynamic relationships of central nervous system effects of scopolamine in healthy subjects

Effect of garlic powder on C-reactive protein and plasma lipids in overweight and smoking subjects

Pharmacokinetics of oral fumarates in healthy subjects

Cognitive performance and serotonergic function in users of ecstasy

Population Pharmacokinetics of Adjunctive Lacosamide in Pediatric Patients With Epilepsy

Intraocular penetration and systemic absorption after topical application of dexamethasone disodium phosphate

Central nervous system effects of alcohol at a pseudo‐steady‐state concentration using alcohol clamping in healthy volunteers

Autonomic Nervous System Function in Chronic Exogenous Subclinical Thyrotoxicosis and the Effect of Restoring Euthyroidism

Brivaracetam Population Pharmacokinetics and Exposure-Response Modeling in Adult Subjects With Partial-Onset Seizures

Modeling and simulation for the evaluation of dose adaptation rules of intravenous lacosamide in children

Brivaracetam population pharmacokinetics in children with epilepsy aged 1 month to 16 years

High concentration of dexamethasone in aqueous and vitreous after subconjunctival injection

Brivaracetam exposure-response predictions in pediatric patients from age 1 month: Extrapolation of levetiracetam adult-pediatric scaling to brivaracetam

Extrapolation of a Brivaracetam Exposure–Response Model from Adults to Children with Focal Seizures

A comparative study of two methods for attaining constant alcohol levels

Circadian Rhythm of Plasma Leptin Levels in Upper and Lower Body Obese Women: Influence of Body Fat Distribution and Weight Loss

Model‐based comparisons of post‐treatment free IgE and FEV1 between omalizumab asthma dosing tables in the United States and European Union

Dexamethasone concentration in the subretinal fluid after a subconjunctival injection, a peribulbar injection, or an oral dose

A compartmental pharmacokinetic model of cyclosporin and its predictive performance after Bayesian estimation in kidney and simultaneous pancreas–kidney transplant recipients

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