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Crystal Structure of an i‐Motif from the HRAS Oncogene Promoter

Angewandte Chemie (International ed.), 2023-06, Vol.62 (26), p.e202301666-n/a

International ed. in English, 2023

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A chemical probe based on the PreQ1 metabolite enables transcriptome-wide mapping of binding sites

Nature communications, 2021-10, Vol.12 (1), p.5856-5856, Article 5856

2021

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Insights Into the Allosteric Inhibition of the SUMO E2 Enzyme Ubc9

Angewandte Chemie (International ed.), 2016-05, Vol.55 (19), p.5703-5707

International ed. in English, 2016

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Machine Learning Informs RNA‐Binding Chemical Space

Angewandte Chemie (International ed.), 2023-03, Vol.62 (11), p.e202211358-n/a

International ed. in English, 2023

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Targeting the Oncogenic Long Non-coding RNA SLNCR1 by Blocking Its Sequence-Specific Binding to the Androgen Receptor

Cell reports (Cambridge), 2020-01, Vol.30 (2), p.541-554.e5

2020

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Dysregulation of Hepatitis B Virus Nucleocapsid Assembly in vitro by RNA-binding Small Ligands

Journal of molecular biology, 2022-05, Vol.434 (10), p.167557-167557, Article 167557

2022

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Parallel Discovery Strategies Provide a Basis for Riboswitch Ligand Design

Cell chemical biology, 2020-10, Vol.27 (10), p.1241-1249.e4

2020

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Structure and Synthesis of the Natural Heptachloro-1′-methyl-1,2′-bipyrrole (Q1)

Angewandte Chemie (International ed.), 2002-05, Vol.41 (10), p.1740-1743

2002

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KDM3B inhibitors disrupt the oncogenic activity of PAX3-FOXO1 in fusion-positive rhabdomyosarcoma

Nature communications, 2024-02, Vol.15 (1), p.1703-19, Article 1703

2024

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Discovery of Small Molecules Targeting the Frameshifting Element RNA in SARS-CoV‑2 Viral Genome

ACS medicinal chemistry letters, 2023-06, Vol.14 (6), p.757-765

2023

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Proximity-Induced Nucleic Acid Degrader (PINAD) Approach to Targeted RNA Degradation Using Small Molecules

ACS central science, 2023-05, Vol.9 (5), p.892-904

2023

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Chemical Approaches to Controlling Intracellular Protein Degradation

Chembiochem : a European journal of chemical biology, 2005-01, Vol.6 (1), p.40-46

2005

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A Small-Molecule Microarray Approach for the Identification of E2 Enzyme Inhibitors in Ubiquitin-Like Conjugation Pathways

SLAS discovery, 2017-07, Vol.22 (6), p.760-766

2017

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The Emerging Role of RNA as a Therapeutic Target for Small Molecules

Cell chemical biology, 2016-09, Vol.23 (9), p.1077-1090

2016

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Probing the hras -1 Y i-motif with small molecules

MedChemComm, 2018-12, Vol.9 (12), p.2000-2007

2018

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Measuring RNA–Ligand Interactions with Microscale Thermophoresis

Biochemistry (Easton), 2018-08, Vol.57 (31), p.4638-4643

2018

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Heterobifunctional molecules tackle targeted protein dephosphorylation

Trends in pharmacological sciences (Regular ed.), 2022-04, Vol.43 (4), p.263-265

2022

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Decoding complexity in biomolecular recognition of DNA i-motifs with microarrays

Nucleic acids research, 2023-12, Vol.51 (22), p.12020

2023

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Selective Small-Molecule Targeting of a Triple Helix Encoded by the Long Noncoding RNA, MALAT1

ACS chemical biology, 2019-02, Vol.14 (2), p.223-235

2019

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Chemical and structural studies provide a mechanistic basis for recognition of the MYC G-quadruplex

Nature communications, 2018-10, Vol.9 (1), p.4229-15, Article 4229

2018

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Evidence for ligandable sites in structured RNA throughout the Protein Data Bank

Bioorganic & medicinal chemistry, 2019-06, Vol.27 (11), p.2253-2260

2019

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Targeting the RNA Polymerase I Transcription for Cancer Therapy Comes of Age

Cells (Basel, Switzerland), 2020-01, Vol.9 (2), p.266

2020

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Custom DNA Microarrays Reveal Diverse Binding Preferences of Proteins and Small Molecules to Thousands of G‑Quadruplexes

ACS chemical biology, 2020-04, Vol.15 (4), p.925-935

2020

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Targeting Mammalian Translational Inhibition with Tetracyclines

Cell chemical biology, 2018-12, Vol.25 (12), p.1437-1438

2018

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Targeting Non-coding RNA Sensitizes Cancer Cells to Drugs

Trends in pharmacological sciences (Regular ed.), 2019-07, Vol.40 (7), p.447-448

2019

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Crystal Structure of an i‐Motif from the HRAS Oncogene Promoter

A chemical probe based on the PreQ1 metabolite enables transcriptome-wide mapping of binding sites

Insights Into the Allosteric Inhibition of the SUMO E2 Enzyme Ubc9

Machine Learning Informs RNA‐Binding Chemical Space

Targeting the Oncogenic Long Non-coding RNA SLNCR1 by Blocking Its Sequence-Specific Binding to the Androgen Receptor

Dysregulation of Hepatitis B Virus Nucleocapsid Assembly in vitro by RNA-binding Small Ligands

Parallel Discovery Strategies Provide a Basis for Riboswitch Ligand Design

Structure and Synthesis of the Natural Heptachloro-1′-methyl-1,2′-bipyrrole (Q1)

KDM3B inhibitors disrupt the oncogenic activity of PAX3-FOXO1 in fusion-positive rhabdomyosarcoma

Discovery of Small Molecules Targeting the Frameshifting Element RNA in SARS-CoV‑2 Viral Genome

Proximity-Induced Nucleic Acid Degrader (PINAD) Approach to Targeted RNA Degradation Using Small Molecules

Chemical Approaches to Controlling Intracellular Protein Degradation

A Small-Molecule Microarray Approach for the Identification of E2 Enzyme Inhibitors in Ubiquitin-Like Conjugation Pathways

The Emerging Role of RNA as a Therapeutic Target for Small Molecules

Probing the hras -1 Y i-motif with small molecules

Measuring RNA–Ligand Interactions with Microscale Thermophoresis

Heterobifunctional molecules tackle targeted protein dephosphorylation

Decoding complexity in biomolecular recognition of DNA i-motifs with microarrays

Selective Small-Molecule Targeting of a Triple Helix Encoded by the Long Noncoding RNA, MALAT1

Chemical and structural studies provide a mechanistic basis for recognition of the MYC G-quadruplex

Evidence for ligandable sites in structured RNA throughout the Protein Data Bank

Targeting the RNA Polymerase I Transcription for Cancer Therapy Comes of Age

Custom DNA Microarrays Reveal Diverse Binding Preferences of Proteins and Small Molecules to Thousands of G‑Quadruplexes

Targeting Mammalian Translational Inhibition with Tetracyclines

Targeting Non-coding RNA Sensitizes Cancer Cells to Drugs

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