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Isavuconazole for treatment of rare invasive fungal diseases

Mycoses, 2018-08, Vol.61 (8), p.518-533

2018

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Isavuconazole for treatment of invasive fungal diseases caused by more than one fungal species

Mycoses, 2018-07, Vol.61 (7), p.485-497

2018

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Population Pharmacokinetics of Isavuconazole in Subjects with Mild or Moderate Hepatic Impairment

Antimicrobial agents and chemotherapy, 2016-05, Vol.60 (5), p.3025-3031

2016

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Prediction of Safety Margin and Optimization of Dosing Protocol for a Novel Antibiotic using Quantitative Systems Pharmacology Modeling

Clinical and translational science, 2018-09, Vol.11 (5), p.498-505

2018

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Isavuconazole versus voriconazole for primary treatment of invasive mould disease caused by Aspergillus and other filamentous fungi (SECURE): a phase 3, randomised-controlled, non-inferiority trial

The Lancet (British edition), 2016-02, Vol.387 (10020), p.760-769

2016

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Monte Carlo Simulations Based on Phase 1 Studies Predict Target Attainment of Ceftobiprole in Nosocomial Pneumonia Patients: a Validation Study

Antimicrobial Agents and Chemotherapy, 2013-05, Vol.57 (5), p.2047-2053

2013

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Tissue Distribution and Elimination of Isavuconazole following Single and Repeat Oral-Dose Administration of Isavuconazonium Sulfate to Rats

Antimicrobial agents and chemotherapy, 2017-12, Vol.61 (12)

2017

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Pharmacokinetic Evaluation of CYP3A4‐Mediated Drug‐Drug Interactions of Isavuconazole With Rifampin, Ketoconazole, Midazolam, and Ethinyl Estradiol/Norethindrone in Healthy Adults

Clinical pharmacology in drug development, 2017-01, Vol.6 (1), p.44-53

2017

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Mechanisms of hepatotoxicity associated with the monocyclic β-lactam antibiotic BAL30072

Archives of toxicology, 2017-11, Vol.91 (11), p.3647-3662

2017

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Physiologically Based Pharmacokinetic (PBPK) Modeling of Disposition of Epiroprim in Humans

Journal of pharmaceutical sciences, 2003-10, Vol.92 (10), p.1990-2007

2003

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Single-Ascending-Dose Pharmacokinetics and Safety of the Novel Broad-Spectrum Antifungal Triazole BAL4815 after Intravenous Infusions (50, 100, and 200 Milligrams) and Oral Administrations (100, 200, and 400 Milligrams) of Its Prodrug, BAL8557, in Healthy Volunteers

Antimicrobial Agents and Chemotherapy, 2006-01, Vol.50 (1), p.279-285

2006

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Multiple-Dose Pharmacokinetics and Safety of the New Antifungal Triazole BAL4815 after Intravenous Infusion and Oral Administration of Its Prodrug, BAL8557, in Healthy Volunteers

Antimicrobial Agents and Chemotherapy, 2006-01, Vol.50 (1), p.286-293

2006

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In Vitro and In Vivo Properties of BAL30376, a β-Lactam and Dual β-Lactamase Inhibitor Combination with Enhanced Activity against Gram-Negative Bacilli That Express Multiple β-Lactamases

Antimicrobial Agents and Chemotherapy, 2011-04, Vol.55 (4), p.1510-1519

2011

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Use of Enzyme Inhibitors to Evaluate the Conversion Pathways of Ester and Amide Prodrugs: A Case Study Example with the Prodrug Ceftobiprole Medocaril

Journal of pharmaceutical sciences, 2012-03, Vol.101 (3), p.1242-1252

2012

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Multiple-Dose Pharmacokinetics and Safety of a Novel Broad-Spectrum Cephalosporin (BAL5788) in Healthy Volunteers

Antimicrobial Agents and Chemotherapy, 2004-07, Vol.48 (7), p.2576-2580

2004

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Efficacies of Ceftobiprole Medocaril and Comparators in a Rabbit Model of Osteomyelitis Due to Methicillin-Resistant Staphylococcus aureus

Antimicrobial Agents and Chemotherapy, 2008-05, Vol.52 (5), p.1618-1622

2008

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Single-Dose Pharmacokinetics and Safety of a Novel Broad-Spectrum Cephalosporin (BAL5788) in Healthy Volunteers

Antimicrobial Agents and Chemotherapy, 2004-07, Vol.48 (7), p.2570-2575

2004

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Use of Monte Carlo Simulations To Select Therapeutic Doses and Provisional Breakpoints of BAL9141

Antimicrobial Agents and Chemotherapy, 2004-05, Vol.48 (5), p.1713-1718

2004

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In Vitro and In Vivo Properties of Dihydrophthalazine Antifolates, a Novel Family of Antibacterial Drugs

Antimicrobial Agents and Chemotherapy, 2009-09, Vol.53 (9), p.3620-3627

2009

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New Antibacterial Agents Derived from the DNA Gyrase Inhibitor Cyclothialidine

Journal of medicinal chemistry, 2004-03, Vol.47 (6), p.1487-1513

2004

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Elucidation of the in vitro metabolic profile of stable isotope labeled BAL19403 by accurate mass capillary liquid chromatography/quadrupole time-of-flight mass spectrometry and isotope exchange

Rapid communications in mass spectrometry, 2007-01, Vol.21 (7), p.1093-1099

2007

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Animal Pharmacokinetics and Interspecies Scaling from Animals to Man of Lamifiban, a New Platelet Aggregation Inhibitor

Journal of pharmacy and pharmacology, 1996-06, Vol.48 (6), p.573-577

1996

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Investigation of low-abundant in vitro metabolites of stable isotope-labelled BAL4815 by accurate mass capillary-LC-ESI-qTof-MS and MS/MS

Journal of mass spectrometry., 2006-07, Vol.41 (7), p.903-910

2006

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Pharmacokinetics and Pharmacodynamics of Ceftobiprole, an Anti-MRSA Cephalosporin with Broad-Spectrum Activity

Clinical pharmacokinetics, 2008, Vol.47 (1), p.21-33

2008

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Combined effects of the siderophore monosulfactam BAL30072 and carbapenems on multidrug-resistant Gram-negative bacilli

Journal of antimicrobial chemotherapy, 2013-05, Vol.68 (5), p.1120-1129

2013

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Isavuconazole for treatment of rare invasive fungal diseases

Isavuconazole for treatment of invasive fungal diseases caused by more than one fungal species

Population Pharmacokinetics of Isavuconazole in Subjects with Mild or Moderate Hepatic Impairment

Prediction of Safety Margin and Optimization of Dosing Protocol for a Novel Antibiotic using Quantitative Systems Pharmacology Modeling

Isavuconazole versus voriconazole for primary treatment of invasive mould disease caused by Aspergillus and other filamentous fungi (SECURE): a phase 3, randomised-controlled, non-inferiority trial

Monte Carlo Simulations Based on Phase 1 Studies Predict Target Attainment of Ceftobiprole in Nosocomial Pneumonia Patients: a Validation Study

Tissue Distribution and Elimination of Isavuconazole following Single and Repeat Oral-Dose Administration of Isavuconazonium Sulfate to Rats

Pharmacokinetic Evaluation of CYP3A4‐Mediated Drug‐Drug Interactions of Isavuconazole With Rifampin, Ketoconazole, Midazolam, and Ethinyl Estradiol/Norethindrone in Healthy Adults

Mechanisms of hepatotoxicity associated with the monocyclic β-lactam antibiotic BAL30072

Physiologically Based Pharmacokinetic (PBPK) Modeling of Disposition of Epiroprim in Humans

Single-Ascending-Dose Pharmacokinetics and Safety of the Novel Broad-Spectrum Antifungal Triazole BAL4815 after Intravenous Infusions (50, 100, and 200 Milligrams) and Oral Administrations (100, 200, and 400 Milligrams) of Its Prodrug, BAL8557, in Healthy Volunteers

Multiple-Dose Pharmacokinetics and Safety of the New Antifungal Triazole BAL4815 after Intravenous Infusion and Oral Administration of Its Prodrug, BAL8557, in Healthy Volunteers

In Vitro and In Vivo Properties of BAL30376, a β-Lactam and Dual β-Lactamase Inhibitor Combination with Enhanced Activity against Gram-Negative Bacilli That Express Multiple β-Lactamases

Use of Enzyme Inhibitors to Evaluate the Conversion Pathways of Ester and Amide Prodrugs: A Case Study Example with the Prodrug Ceftobiprole Medocaril

Multiple-Dose Pharmacokinetics and Safety of a Novel Broad-Spectrum Cephalosporin (BAL5788) in Healthy Volunteers

Efficacies of Ceftobiprole Medocaril and Comparators in a Rabbit Model of Osteomyelitis Due to Methicillin-Resistant Staphylococcus aureus

Single-Dose Pharmacokinetics and Safety of a Novel Broad-Spectrum Cephalosporin (BAL5788) in Healthy Volunteers

Use of Monte Carlo Simulations To Select Therapeutic Doses and Provisional Breakpoints of BAL9141

In Vitro and In Vivo Properties of Dihydrophthalazine Antifolates, a Novel Family of Antibacterial Drugs

New Antibacterial Agents Derived from the DNA Gyrase Inhibitor Cyclothialidine

Elucidation of the in vitro metabolic profile of stable isotope labeled BAL19403 by accurate mass capillary liquid chromatography/quadrupole time-of-flight mass spectrometry and isotope exchange

Animal Pharmacokinetics and Interspecies Scaling from Animals to Man of Lamifiban, a New Platelet Aggregation Inhibitor

Investigation of low-abundant in vitro metabolites of stable isotope-labelled BAL4815 by accurate mass capillary-LC-ESI-qTof-MS and MS/MS

Pharmacokinetics and Pharmacodynamics of Ceftobiprole, an Anti-MRSA Cephalosporin with Broad-Spectrum Activity

Combined effects of the siderophore monosulfactam BAL30072 and carbapenems on multidrug-resistant Gram-negative bacilli

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