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Discovery of GSK1070916, a Potent and Selective Inhibitor of Aurora B/C Kinase

Journal of medicinal chemistry, 2010-05, Vol.53 (10), p.3973-4001

2010

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Discovery of a Potent Class of PI3Kα Inhibitors with Unique Binding Mode via Encoded Library Technology (ELT)

ACS medicinal chemistry letters, 2015-05, Vol.6 (5), p.531-536

2015

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Nonpeptidic urotensin‐II receptor antagonists I: in vitro pharmacological characterization of SB‐706375

British journal of pharmacology, 2005-07, Vol.145 (5), p.620-635

2005

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A novel synthesis of substituted 4H-pyrazolo[3,4-d]pyrimidin-4-ones

Tetrahedron letters, 2007-06, Vol.48 (23), p.3983-3986

2007

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Abstract C62: Identification of GSK2126458, a highly potent inhibitor of phosphoinositide 3-kinase (PI3K) and the mammalian target of rapamycin (mTOR)

Molecular cancer therapeutics, 2009-12, Vol.8 (12_Supplement), p.C62-C62

2009

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Pyridazinodiazepines as a High-Affinity, P2−P3 Peptidomimetic Class of Interleukin-1β-Converting Enzyme Inhibitor

Journal of medicinal chemistry, 1997-06, Vol.40 (13), p.1941-1946

1997

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P1 Aspartate-Based Peptide .alpha.-((2,6-Dichlorobenzoyl)oxy)methyl Ketones as Potent Time-Dependent Inhibitors of Interleukin-1.beta.-Converting Enzyme

Journal of medicinal chemistry, 1994-03, Vol.37 (5), p.563-564

1994

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Discovery of the First Potent and Selective Inhibitor of Centromere-Associated Protein E: GSK923295

ACS medicinal chemistry letters, 2010-04, Vol.1 (1), p.30-34

2010

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A novel synthesis of substituted 4 H-pyrazolo[3,4- d]pyrimidin-4-ones

Tetrahedron letters, 2007, Vol.48 (23), p.3983-3986

2007

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Synthesis of zymosterol, fecosterol, and related biosynthetic sterol intermediates

Journal of the American Chemical Society, 1989, Vol.111 (1), p.278-284

1989

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P1 aspartate-based peptide α-((2,6-dichlorobenzoyl)oxy)methyl ketones as potent time-dependent inhibitors of interleukin-1β-converting enzyme

Journal of medicinal chemistry, 1994-03, Vol.37 (5), p.563-564

1994

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Mechanism and inhibition of .DELTA.24-sterol methyltransferase from Candida albicans and Candida tropicalis

Biochemistry (Easton), 1989-12, Vol.28 (25), p.9633-9640

1989

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Synthesis, specificity, and antifungal activity of inhibitors of the Candida albicans .DELTA.24-sterol methyltransferase

Journal of medicinal chemistry, 1992-01, Vol.35 (1), p.100-106

1992

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Observation of an aziridine intermediate in a displacement reaction on tetrahydro-5-(tosyloxy)-2(1H)-pyrimidinone

Journal of organic chemistry, 1984-11, Vol.49 (23), p.4555-4557

1984

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Pyridazinodiazepines as a High-Affinity, P 2 −P 3 Peptidomimetic Class of Interleukin-1β-Converting Enzyme Inhibitor

Journal of medicinal chemistry, 1997-06, Vol.40 (13), p.1941-1946

1997

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Bicyclic N-Hydroxyurea Inhibitors of 5-Lipoxygenase: Pharmacodynamic, Pharmacokinetic, and in Vitro Metabolic Studies Characterizing N-Hydroxy-N-(2,3-dihydro-6-(phenylmethoxy)-3-benzofuranyl)urea

Journal of medicinal chemistry, 1996-12, Vol.39 (26), p.5035-5046

1996

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Palladium catalysed alkoxycarbonylation of phenols to benzoate esters

Journal of the Chemical Society. Chemical communications, 1987 (12), p.904-905

1987

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3-chloro-4-carboxamido-6-arylpyridazines as a non-peptide class of interleukin-1β converting enzyme inhibitor

Bioorganic & medicinal chemistry letters, 1997-04, Vol.7 (8), p.1003-1006

1997

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Characterization of a continuous fluorogenic assay for calpain I. Kinetic evaluation of peptide aldehydes, halomethyl ketones and (acyloxy)methyl ketones as inhibitors of the enzyme

Bioorganic & medicinal chemistry letters, 1995-02, Vol.5 (4), p.393-398

1995

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THE AMINOGLYCOSIDE ANTIBIOTICS: IV SYNTHESIS OF AMINODEOXY ANALOGS OF NEAMINE

The Journal of Antibiotics, 1980, Vol.33(4), pp.383-392

1980

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Inhibition of human erythrocyte calpain I by novel quinolinecarboxamides

Bioorganic & medicinal chemistry letters, 1995-02, Vol.5 (4), p.387-392

1995

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Synthesis of zymosterol: salient intermediate of fungal and mammalian sterol biosynthesis

Journal of the Chemical Society. Chemical communications, 1988 (1), p.19-21

1988

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New IDH1 mutant inhibitors for treatment of acute myeloid leukemia

Discovery of GSK1070916, a Potent and Selective Inhibitor of Aurora B/C Kinase

Discovery of GSK2126458, a Highly Potent Inhibitor of PI3K and the Mammalian Target of Rapamycin

Discovery of a Potent Class of PI3Kα Inhibitors with Unique Binding Mode via Encoded Library Technology (ELT)

Nonpeptidic urotensin‐II receptor antagonists I: in vitro pharmacological characterization of SB‐706375

A novel synthesis of substituted 4H-pyrazolo[3,4-d]pyrimidin-4-ones

Abstract C62: Identification of GSK2126458, a highly potent inhibitor of phosphoinositide 3-kinase (PI3K) and the mammalian target of rapamycin (mTOR)

Pyridazinodiazepines as a High-Affinity, P2−P3 Peptidomimetic Class of Interleukin-1β-Converting Enzyme Inhibitor

P1 Aspartate-Based Peptide .alpha.-((2,6-Dichlorobenzoyl)oxy)methyl Ketones as Potent Time-Dependent Inhibitors of Interleukin-1.beta.-Converting Enzyme

Discovery of the First Potent and Selective Inhibitor of Centromere-Associated Protein E: GSK923295

A novel synthesis of substituted 4 H-pyrazolo[3,4- d]pyrimidin-4-ones

Synthesis of zymosterol, fecosterol, and related biosynthetic sterol intermediates

P1 aspartate-based peptide α-((2,6-dichlorobenzoyl)oxy)methyl ketones as potent time-dependent inhibitors of interleukin-1β-converting enzyme

Mechanism and inhibition of .DELTA.24-sterol methyltransferase from Candida albicans and Candida tropicalis

Synthesis, specificity, and antifungal activity of inhibitors of the Candida albicans .DELTA.24-sterol methyltransferase

Discovery of GSK2126458, a Highly Potent Inhibitor of PI3K and the Mammalian Target of Rapamycin

Observation of an aziridine intermediate in a displacement reaction on tetrahydro-5-(tosyloxy)-2(1H)-pyrimidinone

Pyridazinodiazepines as a High-Affinity, P 2 −P 3 Peptidomimetic Class of Interleukin-1β-Converting Enzyme Inhibitor

Bicyclic N-Hydroxyurea Inhibitors of 5-Lipoxygenase: Pharmacodynamic, Pharmacokinetic, and in Vitro Metabolic Studies Characterizing N-Hydroxy-N-(2,3-dihydro-6-(phenylmethoxy)-3-benzofuranyl)urea

Palladium catalysed alkoxycarbonylation of phenols to benzoate esters

3-chloro-4-carboxamido-6-arylpyridazines as a non-peptide class of interleukin-1β converting enzyme inhibitor

Characterization of a continuous fluorogenic assay for calpain I. Kinetic evaluation of peptide aldehydes, halomethyl ketones and (acyloxy)methyl ketones as inhibitors of the enzyme

THE AMINOGLYCOSIDE ANTIBIOTICS: IV SYNTHESIS OF AMINODEOXY ANALOGS OF NEAMINE

Inhibition of human erythrocyte calpain I by novel quinolinecarboxamides

Synthesis of zymosterol: salient intermediate of fungal and mammalian sterol biosynthesis

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