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Exploiting Nanobodies’ Singular Traits

Annual review of immunology, 2018-04, Vol.36 (1), p.695-715

2018

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Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape

Science (American Association for the Advancement of Science), 2021-02, Vol.371 (6530), p.691

2021

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HDAC6 mediates an aggresome-like mechanism for NLRP3 and pyrin inflammasome activation

Science (American Association for the Advancement of Science), 2020-09, Vol.369 (6510)

2020

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Transcriptional licensing is required for Pyrin inflammasome activation in human macrophages and bypassed by mutations causing familial Mediterranean fever

PLoS biology, 2022-11, Vol.20 (11), p.e3001351

2022

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Localized CD47 blockade enhances immunotherapy for murine melanoma

Proceedings of the National Academy of Sciences - PNAS, 2017-09, Vol.114 (38), p.10184-10189

2017

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Pyroptosis inhibiting nanobodies block Gasdermin D pore formation

Nature communications, 2023-12, Vol.14 (1), p.7923-7923, Article 7923

2023

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ASC oligomer favors caspase-1CARD domain recruitment after intracellular potassium efflux

The Journal of cell biology, 2023-08, Vol.222 (8), p.1

2023

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Vaccinia virus strains use distinct forms of macropinocytosis for host-cell entry

Proceedings of the National Academy of Sciences - PNAS, 2010-05, Vol.107 (20), p.9346-9351

2010

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Nuclear PYHIN proteins target the host transcription factor Sp1 thereby restricting HIV-1 in human macrophages and CD4+ T cells

PLoS pathogens, 2020-08, Vol.16 (8), p.e1008752-e1008752

2020

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Multi-omics characterization of the monkeypox virus infection

Nature communications, 2024-08, Vol.15 (1), p.6778-19, Article 6778

2024

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Nanobody-directed targeting of optogenetic tools to study signaling in the primary cilium

eLife, 2020-06, Vol.9

2020

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Antagonistic nanobodies implicate mechanism of GSDMD pore formation and potential therapeutic application

Nature communications, 2024-09, Vol.15 (1), p.8266-18, Article 8266

2024

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Disruption of Sphingolipid Biosynthesis Blocks Phagocytosis of Candida albicans

PLoS pathogens, 2015-10, Vol.11 (10), p.e1005188-e1005188

2015

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The endogenous cellular protease inhibitor SPINT2 controls SARS-CoV-2 viral infection and is associated to disease severity

PLoS pathogens, 2021-06, Vol.17 (6), p.e1009687-e1009687

2021

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Quantitative proteomics defines mechanisms of antiviral defence and cell death during modified vaccinia Ankara infection

Nature communications, 2023-12, Vol.14 (1), p.8134-8134, Article 8134

2023

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Amino Acid Residues in the N-Terminal Region of the PA Subunit of Influenza A Virus RNA Polymerase Play a Critical Role in Protein Stability, Endonuclease Activity, Cap Binding, and Virion RNA Promoter Binding

Journal of Virology, 2006-08, Vol.80 (16), p.7789-7798

2006

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Intracellular expression of camelid single-domain antibodies specific for influenza virus nucleoprotein uncovers distinct features of its nuclear localization

Journal of virology, 2015-03, Vol.89 (5), p.2792-2800

2015

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Nanobodies dismantle post‐pyroptotic ASC specks and counteract inflammation in vivo

EMBO molecular medicine, 2022-06, Vol.14 (6), p.e15415-n/a

2022

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Single-Virus Fusion Experiments Reveal Proton Influx into Vaccinia Virions and Hemifusion Lag Times

Biophysical journal, 2013-07, Vol.105 (2), p.420-431

2013

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The E2 Ubiquitin-conjugating Enzyme UBE2J1 Is Required for Spermiogenesis in Mice

The Journal of biological chemistry, 2014-12, Vol.289 (50), p.34490-34502

2014

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The Antiviral Mechanism of an Influenza A Virus Nucleoprotein-Specific Single-Domain Antibody Fragment

mBio, 2016-12, Vol.7 (6)

2016

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Jack of all trades inhibits inflammation (in sober people)

Nature immunology, 2020-07, Vol.21 (7), p.718-719

2020

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From atoms to physiology: what it takes to really understand inflammasomes

The Journal of physiology, 2019-11, Vol.597 (22), p.5335-5348

Schmidt, Florian I.

2019

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A single domain antibody fragment that recognizes the adaptor ASC defines the role of ASC domains in inflammasome assembly

The Journal of experimental medicine, 2016-05, Vol.213 (5), p.771-790

2016

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Vaccinia Virus Egress: Actin OUT with ClathrIN

Cell host & microbe, 2012-09, Vol.12 (3), p.263-265

2012

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Exploiting Nanobodies’ Singular Traits

Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape

HDAC6 mediates an aggresome-like mechanism for NLRP3 and pyrin inflammasome activation

Transcriptional licensing is required for Pyrin inflammasome activation in human macrophages and bypassed by mutations causing familial Mediterranean fever

Localized CD47 blockade enhances immunotherapy for murine melanoma

Pyroptosis inhibiting nanobodies block Gasdermin D pore formation

ASC oligomer favors caspase-1CARD domain recruitment after intracellular potassium efflux

Vaccinia virus strains use distinct forms of macropinocytosis for host-cell entry

Nuclear PYHIN proteins target the host transcription factor Sp1 thereby restricting HIV-1 in human macrophages and CD4+ T cells

Multi-omics characterization of the monkeypox virus infection

Nanobody-directed targeting of optogenetic tools to study signaling in the primary cilium

Antagonistic nanobodies implicate mechanism of GSDMD pore formation and potential therapeutic application

Disruption of Sphingolipid Biosynthesis Blocks Phagocytosis of Candida albicans

The endogenous cellular protease inhibitor SPINT2 controls SARS-CoV-2 viral infection and is associated to disease severity

Quantitative proteomics defines mechanisms of antiviral defence and cell death during modified vaccinia Ankara infection

Amino Acid Residues in the N-Terminal Region of the PA Subunit of Influenza A Virus RNA Polymerase Play a Critical Role in Protein Stability, Endonuclease Activity, Cap Binding, and Virion RNA Promoter Binding

Intracellular expression of camelid single-domain antibodies specific for influenza virus nucleoprotein uncovers distinct features of its nuclear localization

Nanobodies dismantle post‐pyroptotic ASC specks and counteract inflammation in vivo

Single-Virus Fusion Experiments Reveal Proton Influx into Vaccinia Virions and Hemifusion Lag Times

The E2 Ubiquitin-conjugating Enzyme UBE2J1 Is Required for Spermiogenesis in Mice

The Antiviral Mechanism of an Influenza A Virus Nucleoprotein-Specific Single-Domain Antibody Fragment

Jack of all trades inhibits inflammation (in sober people)

From atoms to physiology: what it takes to really understand inflammasomes

A single domain antibody fragment that recognizes the adaptor ASC defines the role of ASC domains in inflammasome assembly

Vaccinia Virus Egress: Actin OUT with ClathrIN

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