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Protection of host cells by complement regulators

Immunological reviews, 2016-11, Vol.274 (1), p.152-171

2016

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Incomplete inhibition by eculizumab: mechanistic evidence for residual C5 activity during strong complement activation

Blood, 2017-02, Vol.129 (8), p.970-980

2017

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Regulator-dependent mechanisms of C3b processing by factor I allow differentiation of immune responses

Nature structural & molecular biology, 2017-08, Vol.24 (8), p.643

2017

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Identification of factor H-like protein 1 as the predominant complement regulator in Bruch's membrane: implications for age-related macular degeneration

The Journal of immunology (1950), 2014-11, Vol.193 (10), p.4962-4970

2014

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Biophysical analysis of sialic acid recognition by the complement regulator Factor H

Glycobiology (Oxford), 2018-10, Vol.28 (10), p.765-773

2018

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Tuning the Functionality by Splicing: Factor H and Its Alternative Splice Variant FHL-1 Share a Gene but Not All Functions

Frontiers in immunology, 2020-10, Vol.11, p.596415-596415

2020

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Hexon modification to improve the activity of oncolytic adenovirus vectors against neoplastic and stromal cells in pancreatic cancer

PloS one, 2015-02, Vol.10 (2), p.e0117254-e0117254

2015

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Human α-Defensin-6 Neutralizes Clostridioides difficile Toxins TcdA and TcdB by Direct Binding

International journal of molecular sciences, 2022-04, Vol.23 (9), p.4509

2022

Volltextzugriff (PDF)

Chrysosplenol d, a Flavonol from Artemisia annua , Induces ERK1/2-Mediated Apoptosis in Triple Negative Human Breast Cancer Cells

International journal of molecular sciences, 2020-06, Vol.21 (11), p.4090

2020

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Structural basis for engagement by complement factor H of C3b on a self surface

Nature structural & molecular biology, 2011-04, Vol.18 (4), p.463

2011

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It's all about complement balance, again

Blood, 2024-03, Vol.143 (11), p.949

Schmidt, Christoph Q

2024

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Recruitment of Factor H as a Novel Complement Evasion Strategy for Blood-Stage Plasmodium falciparum Infection

The Journal of immunology (1950), 2016-02, Vol.196 (3), p.1239-1248

2016

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Complement receptor 1 is the host erythrocyte receptor for Plasmodium falciparum PfRh4 invasion ligand

Proceedings of the National Academy of Sciences - PNAS, 2010-10, Vol.107 (40), p.17327-17332

2010

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Gliosis-dependent expression of complement factor H truncated variants attenuates retinal neurodegeneration following ischemic injury

Journal of neuroinflammation, 2024-02, Vol.21 (1), p.56-56, Article 56

2024

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Human lysozyme inhibits the fibrillation of serum amyloid a protein from systemic AA amyloidosis

Amyloid, 2023-10, Vol.ahead-of-print (ahead-of-print), p.1-10

2023

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Complement and the prothrombotic state

Blood, 2022-03, Vol.139 (13), p.1954-1972

2022

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Complement inhibition can decrease the haemostatic response in a microvascular bleeding model at multiple levels

Frontiers in immunology, 2023-09, Vol.14, p.1226832-1226832

2023

Volltextzugriff (PDF)

Comparative Analysis of Novel Complement-Targeted Inhibitors, MiniFH, and the Natural Regulators Factor H and Factor H-like Protein 1 Reveal Functional Determinants of Complement Regulation

The Journal of immunology (1950), 2016-01, Vol.196 (2), p.866-876

2016

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Complement C5a Induces Pro-inflammatory Microvesicle Shedding in Severely Injured Patients

Frontiers in immunology, 2020-09, Vol.11, p.1789-1789

2020

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A New Map of Glycosaminoglycan and C3b Binding Sites on Factor H

The Journal of immunology (1950), 2008-08, Vol.181 (4), p.2610-2619

2008

Volltextzugriff (PDF)

The complement model disease paroxysmal nocturnal hemoglobinuria

European journal of immunology, 2024-08, p.e2350817

2024

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Factor H Autoantibodies and Complement-Mediated Diseases

Frontiers in immunology, 2020-12, Vol.11, p.607211-607211

2020

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Deregulation of Factor H by Factor H-Related Protein 1 Depends on Sialylation of Host Surfaces

Frontiers in immunology, 2021-02, Vol.12, p.615748-615748

2021

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Different Levels of Incomplete Terminal Pathway Inhibition by Eculizumab and the Clinical Response of PNH Patients

Frontiers in immunology, 2019-07, Vol.10, p.1639-1639

2019

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Combined Heterozygous Genetic Variations in Complement C2 and C8B: An Explanation for Multidimensional Immune Imbalance?

Journal of innate immunity, 2023-01, Vol.15 (1), p.412-427

2023

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Protection of host cells by complement regulators

Incomplete inhibition by eculizumab: mechanistic evidence for residual C5 activity during strong complement activation

Regulator-dependent mechanisms of C3b processing by factor I allow differentiation of immune responses

Identification of factor H-like protein 1 as the predominant complement regulator in Bruch's membrane: implications for age-related macular degeneration

Biophysical analysis of sialic acid recognition by the complement regulator Factor H

Tuning the Functionality by Splicing: Factor H and Its Alternative Splice Variant FHL-1 Share a Gene but Not All Functions

Hexon modification to improve the activity of oncolytic adenovirus vectors against neoplastic and stromal cells in pancreatic cancer

Human α-Defensin-6 Neutralizes Clostridioides difficile Toxins TcdA and TcdB by Direct Binding

Chrysosplenol d, a Flavonol from Artemisia annua , Induces ERK1/2-Mediated Apoptosis in Triple Negative Human Breast Cancer Cells

Structural basis for engagement by complement factor H of C3b on a self surface

It's all about complement balance, again

Recruitment of Factor H as a Novel Complement Evasion Strategy for Blood-Stage Plasmodium falciparum Infection

Complement receptor 1 is the host erythrocyte receptor for Plasmodium falciparum PfRh4 invasion ligand

Gliosis-dependent expression of complement factor H truncated variants attenuates retinal neurodegeneration following ischemic injury

Human lysozyme inhibits the fibrillation of serum amyloid a protein from systemic AA amyloidosis

Complement and the prothrombotic state

Complement inhibition can decrease the haemostatic response in a microvascular bleeding model at multiple levels

Comparative Analysis of Novel Complement-Targeted Inhibitors, MiniFH, and the Natural Regulators Factor H and Factor H-like Protein 1 Reveal Functional Determinants of Complement Regulation

Complement C5a Induces Pro-inflammatory Microvesicle Shedding in Severely Injured Patients

A New Map of Glycosaminoglycan and C3b Binding Sites on Factor H

The complement model disease paroxysmal nocturnal hemoglobinuria

Factor H Autoantibodies and Complement-Mediated Diseases

Deregulation of Factor H by Factor H-Related Protein 1 Depends on Sialylation of Host Surfaces

Different Levels of Incomplete Terminal Pathway Inhibition by Eculizumab and the Clinical Response of PNH Patients

Combined Heterozygous Genetic Variations in Complement C2 and C8B: An Explanation for Multidimensional Immune Imbalance?

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