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Synthesis and structure-activity relationships of pyrazole-based inhibitors of meprin α and β

Journal of enzyme inhibition and medicinal chemistry, 2023-12, Vol.38 (1), p.2165648-2165648

2023

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Helical ultrastructure of the metalloprotease meprin α in complex with a small molecule inhibitor

Nature communications, 2022-10, Vol.13 (1), p.6178-6178, Article 6178

2022

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Pyroglutamate Formation Influences Solubility and Amyloidogenicity of Amyloid Peptides

Biochemistry (Easton), 2009-07, Vol.48 (29), p.7072-7078

2009

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Crystal structure of the incretin-bound extracellular domain of a G protein-coupled receptor

Proceedings of the National Academy of Sciences - PNAS, 2007-08, Vol.104 (35), p.13942-13947

2007

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Structure and Dynamics of Meprin β in Complex with a Hydroxamate-Based Inhibitor

International journal of molecular sciences, 2021-05, Vol.22 (11), p.5651

2021

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N-Terminal pyroglutamate formation of Aβ38 and Aβ40 enforces oligomer formation and potency to disrupt hippocampal long-term potentiation

Journal of neurochemistry, 2012-06, Vol.121 (5), p.774-784

2012

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Heterologous Expression of the Astacin Protease Meprin β in Pichia pastoris

Methods in molecular biology (Clifton, N.J.), 2017, Vol.1579, p.35

2017

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Improved glucose tolerance in Zucker fatty rats by oral administration of the dipeptidyl peptidase IV inhibitor isoleucine thiazolidide

Diabetes (New York, N.Y.), 1998-08, Vol.47 (8), p.1253

1998

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First insight into structure-activity relationships of selective meprin β inhibitors

Bioorganic & medicinal chemistry letters, 2017-06, Vol.27 (11), p.2428-2431

2017

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Structure-Guided Design, Synthesis, and Characterization of Next-Generation Meprin β Inhibitors

Journal of medicinal chemistry, 2018-05, Vol.61 (10), p.4578-4592

2018

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Continuous assays for meprin alpha and beta using prolyl tripeptidyl aminopeptidase (PtP) from Porphyromonas gingivalis

Analytical biochemistry, 2018-10, Vol.559, p.11-16

2018

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Concerted action of dipeptidyl peptidase IV and glutaminyl cyclase results in formation of pyroglutamate-modified amyloid peptides in vitro

Neurochemistry international, 2018-02, Vol.113, p.112-119

2018

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Tertiary‐Amine‐Based Inhibitors of the Astacin Protease Meprin α

ChemMedChem, 2018-08, Vol.13 (16), p.1619-1624

2018

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Glutaminyl cyclase inhibition attenuates pyroglutamate Aβ and Alzheimer's disease-like pathology

Nature medicine, 2008-10, Vol.14 (10), p.1106-1111

2008

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N-Terminal pyroglutamate formation of A beta 38 and A beta 40 enforces oligomer formation and potency to disrupt hippocampal long-term potentiation

Journal of neurochemistry, 2012-06, Vol.121 (5), p.774-784

2012

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Purification of recombinant Aβ(1‐42) and pGlu‐Aβ(3‐42) using preparative SDS‐PAGE

Electrophoresis, 2017-08, Vol.38 (16), p.2042-2049

2017

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Heteroaromatic Inhibitors of the Astacin Proteinases Meprin α, Meprin β and Ovastacin Discovered by a Scaffold‐Hopping Approach

ChemMedChem, 2021-03, Vol.16 (6), p.976-988

2021

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Enhanced Fibril Fragmentation of N-Terminally Truncated and Pyroglutamyl-Modified A[beta] Peptides

Angewandte Chemie International Edition, 2016-04, Vol.55 (16), p.5081

International ed. in English, 2016

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Metabolism of glucagon by dipeptidyl peptidase IV (CD26)

Regulatory peptides, 2001-01, Vol.96 (3), p.133-141

2001

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Enhanced Fibril Fragmentation of N-Terminally Truncated and Pyroglutamyl-Modified Aβ Peptides

Angewandte Chemie (International ed.), 2016-04, Vol.55 (16), p.5081-5084

2016

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Acetylcholinesterase inhibitors from the toadstool Cortinarius infractus

Bioorganic & medicinal chemistry, 2010-03, Vol.18 (6), p.2173-2177

2010

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Proteolytic degradation of neuropeptide Y (NPY) from head to toe: Identification of novel NPY‐cleaving peptidases and potential drug interactions in CNS and Periphery

Journal of neurochemistry, 2015-12, Vol.135 (5), p.1019-1037

2015

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P4‐298: Meprin β is Associated with Formation of Pyroglutamate‐Modified Aβ Peptides

Alzheimer's & dementia, 2016-07, Vol.12 (7S_Part_23), p.P1147-P1148

2016

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MEPRIN β IS ASSOCIATED WITH FORMATION OF PYROGLUTAMATE-MODIFIED Aβ PEPTIDES

Alzheimer's & dementia, 2016-07, Vol.12 (7), p.P1147-P1148

2016

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P1‐077: EVIDENCE FOR INVOLVEMENT OF MEPRIN B IN FORMATION OF N‐TRUNCATED AND PYROGLUTAMATE ‐MODIFIED (PGLU) ABETA

Alzheimer's & dementia, 2014-07, Vol.10 (4S_Part_8), p.P331-P331

2014

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Synthesis and structure-activity relationships of pyrazole-based inhibitors of meprin α and β

Helical ultrastructure of the metalloprotease meprin α in complex with a small molecule inhibitor

Pyroglutamate Formation Influences Solubility and Amyloidogenicity of Amyloid Peptides

Crystal structure of the incretin-bound extracellular domain of a G protein-coupled receptor

Structure and Dynamics of Meprin β in Complex with a Hydroxamate-Based Inhibitor

N-Terminal pyroglutamate formation of Aβ38 and Aβ40 enforces oligomer formation and potency to disrupt hippocampal long-term potentiation

Heterologous Expression of the Astacin Protease Meprin β in Pichia pastoris

Improved glucose tolerance in Zucker fatty rats by oral administration of the dipeptidyl peptidase IV inhibitor isoleucine thiazolidide

First insight into structure-activity relationships of selective meprin β inhibitors

Structure-Guided Design, Synthesis, and Characterization of Next-Generation Meprin β Inhibitors

Continuous assays for meprin alpha and beta using prolyl tripeptidyl aminopeptidase (PtP) from Porphyromonas gingivalis

Concerted action of dipeptidyl peptidase IV and glutaminyl cyclase results in formation of pyroglutamate-modified amyloid peptides in vitro

Tertiary‐Amine‐Based Inhibitors of the Astacin Protease Meprin α

Glutaminyl cyclase inhibition attenuates pyroglutamate Aβ and Alzheimer's disease-like pathology

N-Terminal pyroglutamate formation of A beta 38 and A beta 40 enforces oligomer formation and potency to disrupt hippocampal long-term potentiation

Purification of recombinant Aβ(1‐42) and pGlu‐Aβ(3‐42) using preparative SDS‐PAGE

Heteroaromatic Inhibitors of the Astacin Proteinases Meprin α, Meprin β and Ovastacin Discovered by a Scaffold‐Hopping Approach

Enhanced Fibril Fragmentation of N-Terminally Truncated and Pyroglutamyl-Modified A[beta] Peptides

Metabolism of glucagon by dipeptidyl peptidase IV (CD26)

Enhanced Fibril Fragmentation of N-Terminally Truncated and Pyroglutamyl-Modified Aβ Peptides

Acetylcholinesterase inhibitors from the toadstool Cortinarius infractus

Proteolytic degradation of neuropeptide Y (NPY) from head to toe: Identification of novel NPY‐cleaving peptidases and potential drug interactions in CNS and Periphery

P4‐298: Meprin β is Associated with Formation of Pyroglutamate‐Modified Aβ Peptides

MEPRIN β IS ASSOCIATED WITH FORMATION OF PYROGLUTAMATE-MODIFIED Aβ PEPTIDES

P1‐077: EVIDENCE FOR INVOLVEMENT OF MEPRIN B IN FORMATION OF N‐TRUNCATED AND PYROGLUTAMATE ‐MODIFIED (PGLU) ABETA

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