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3‑[(1S,2S,3R)‑2,3-Difluoro-1-hydroxy-7-methylsulfonylindan-4-yl]oxy-5-fluorobenzonitrile (PT2977), a Hypoxia-Inducible Factor 2α (HIF-2α) Inhibitor for the Treatment of Clear Cell Renal Cell Carcinoma

Journal of medicinal chemistry, 2019-08, Vol.62 (15), p.6876-6893

2019

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A Small-Molecule Antagonist of HIF2α Is Efficacious in Preclinical Models of Renal Cell Carcinoma

Cancer research (Chicago, Ill.), 2016-09, Vol.76 (18), p.5491-5500

2016

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DNA-dependent protein kinase inhibitors as drug candidates for the treatment of cancer

Molecular cancer therapeutics, 2003-12, Vol.2 (12), p.1257

2003

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Lead change of a HIF-2α antagonist guided by multiparameter optimization and utilization of an Olp→πAr interaction

Medicinal chemistry research, 2023-07, Vol.32 (7), p.1510-1531

2023

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Discovery of a Novel Class of Imidazo[1,2‑a]Pyridines with Potent PDGFR Activity and Oral Bioavailability

ACS medicinal chemistry letters, 2014-01, Vol.5 (1), p.78-83

2014

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Carbonyl-Containing Bisphosphonate Esters as Novel Antiinflammatory and Antiarthritic Agents

Journal of medicinal chemistry, 1994-12, Vol.37 (26), p.4449-4454

1994

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Pyrimidine Thioethers: A Novel Class of HIV-1 Reverse Transcriptase Inhibitors with Activity Against BHAP-Resistant HIV

Journal of medicinal chemistry, 1998-09, Vol.41 (20), p.3793-3803

1998

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Pyrazoline bisphosphonate esters as novel antiinflammatory and antiarthritic agents

Journal of medicinal chemistry, 1993, Vol.36 (1), p.134-139

1993

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Abstract B140: PT2977, a novel HIF-2a antagonist, has potent antitumor activity and remodels the immunosuppressive tumor microenvironment in clear cell renal cell cancer

Molecular cancer therapeutics, 2018-01, Vol.17 (1_Supplement), p.B140-B140

2018

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Abstract DDT01-01: PT2385: First-in-class HIF-2α antagonist for the treatment of renal cell carcinoma

Cancer research (Chicago, Ill.), 2015-08, Vol.75 (15_Supplement), p.DDT01-01-DDT01-01

2015

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Anti-inflammatory/antiarthritic ketonic bisphosphonic acid esters

Bioorganic & medicinal chemistry letters, 1998-05, Vol.8 (9), p.1093-1096

1998

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New Anti-Inflammatory/Anti-Arthritic Heterocyclic Bisphosphonates

Phosphorus, sulfur, and silicon and the related elements, 1996-01, Vol.109 (1-4), p.229-232

1996

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Insight into the unusual reactions of stabilized phosphorus ylides with lactols. A specific intramolecular hydroxyl group effect leads to high z-selectivity

Tetrahedron letters, 1988, Vol.29 (52), p.6823-6826

1988

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Discovery and Preclinical Pharmacology of a Selective ATP-Competitive Akt Inhibitor (GDC-0068) for the Treatment of Human Tumors

Journal of medicinal chemistry, 2012-09, Vol.55 (18), p.8110-8127

2012

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Modulating fast skeletal muscle contraction protects skeletal muscle in animal models of Duchenne muscular dystrophy

The Journal of clinical investigation, 2023-05, Vol.133 (10), p.1-14

2023

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EDG-002, A NOVEL TARGETED SARCOMERE REGULATOR PRESERVES INTRINSIC MYOSIN-MOTOR FUNCTION, BLUNTS HYPERCONTRACTILITY AND ELIMINATES LVOT OBSTRUCTION IN CATS WITH HYPERTROPHIC CARDIOMYOPATHY: IN VITRO AND IN VIVO EVIDENCE

Journal of the American College of Cardiology, 2023-03, Vol.81 (8), p.349-349

2023

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High-resolution three-dimensional imaging of biofilm development using optical coherence tomography

Journal of Biomedical Optics, 2006-05, Vol.11 (3), p.034001-034006

2006

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Nonparaxial vector-field modeling of optical coherence tomography and interferometric synthetic aperture microscopy

Journal of the Optical Society of America. A, Optics, image science, and vision, 2007-09, Vol.24 (9), p.2527

2007

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Non-oxime inhibitors of B-Raf(V600E) kinase

Bioorganic & medicinal chemistry letters, 2011-02, Vol.21 (4), p.1243-1247

2011

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The Discovery of furo[2,3- c]pyridine-based indanone oximes as potent and selective B-Raf inhibitors

Bioorganic & medicinal chemistry letters, 2011-02, Vol.21 (4), p.1248-1252

2011

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Group refractive index reconstruction with broadband interferometric confocal microscopy

Journal of the Optical Society of America. A, Optics, image science, and vision, 2008-05, Vol.25 (5), p.1156

2008

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3‑[(1S,2S,3R)‑2,3-Difluoro-1-hydroxy-7-methylsulfonylindan-4-yl]oxy-5-fluorobenzonitrile (PT2977), a Hypoxia-Inducible Factor 2α (HIF-2α) Inhibitor for the Treatment of Clear Cell Renal Cell Carcinoma

A Small-Molecule Antagonist of HIF2α Is Efficacious in Preclinical Models of Renal Cell Carcinoma

Design and Activity of Specific Hypoxia-Inducible Factor-2α (HIF-2α) Inhibitors for the Treatment of Clear Cell Renal Cell Carcinoma: Discovery of Clinical Candidate ( S)-3-((2,2-Difluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1 H-inden-4-yl)oxy)-5-fluorobenzonitrile (PT2385)

Design and Activity of Specific Hypoxia-Inducible Factor-2α (HIF-2α) Inhibitors for the Treatment of Clear Cell Renal Cell Carcinoma: Discovery of Clinical Candidate (S)‑3-((2,2-Difluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro‑1H‑inden-4-yl)oxy)-5-fluorobenzonitrile (PT2385)

DNA-dependent protein kinase inhibitors as drug candidates for the treatment of cancer

Lead change of a HIF-2α antagonist guided by multiparameter optimization and utilization of an Olp→πAr interaction

Discovery of a Novel Class of Imidazo[1,2‑a]Pyridines with Potent PDGFR Activity and Oral Bioavailability

Carbonyl-Containing Bisphosphonate Esters as Novel Antiinflammatory and Antiarthritic Agents

Pyrimidine Thioethers: A Novel Class of HIV-1 Reverse Transcriptase Inhibitors with Activity Against BHAP-Resistant HIV

Pyrazoline bisphosphonate esters as novel antiinflammatory and antiarthritic agents

Abstract B140: PT2977, a novel HIF-2a antagonist, has potent antitumor activity and remodels the immunosuppressive tumor microenvironment in clear cell renal cell cancer

Abstract DDT01-01: PT2385: First-in-class HIF-2α antagonist for the treatment of renal cell carcinoma

(−)-6-Chloro-2-[(1-furo[2,3-c]pyridin-5-ylethyl)thio]-4-pyrimidinamine, PNU-142721, a New Broad Spectrum HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitor

Anti-inflammatory/antiarthritic ketonic bisphosphonic acid esters

New Anti-Inflammatory/Anti-Arthritic Heterocyclic Bisphosphonates

Insight into the unusual reactions of stabilized phosphorus ylides with lactols. A specific intramolecular hydroxyl group effect leads to high z-selectivity

Discovery and Preclinical Pharmacology of a Selective ATP-Competitive Akt Inhibitor (GDC-0068) for the Treatment of Human Tumors

Modulating fast skeletal muscle contraction protects skeletal muscle in animal models of Duchenne muscular dystrophy

Human bile contains MicroRNA‐laden extracellular vesicles that can be used for cholangiocarcinoma diagnosis

EDG-002, A NOVEL TARGETED SARCOMERE REGULATOR PRESERVES INTRINSIC MYOSIN-MOTOR FUNCTION, BLUNTS HYPERCONTRACTILITY AND ELIMINATES LVOT OBSTRUCTION IN CATS WITH HYPERTROPHIC CARDIOMYOPATHY: IN VITRO AND IN VIVO EVIDENCE

High-resolution three-dimensional imaging of biofilm development using optical coherence tomography

Nonparaxial vector-field modeling of optical coherence tomography and interferometric synthetic aperture microscopy

Non-oxime inhibitors of B-Raf(V600E) kinase

The Discovery of furo[2,3- c]pyridine-based indanone oximes as potent and selective B-Raf inhibitors

Group refractive index reconstruction with broadband interferometric confocal microscopy

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