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Difluoromethyleneketone retroamide, a versatile concept of inactivation of proteolytic enzymes

Tetrahedron, 1996, Vol.52 (1), p.305-318

1996

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General synthesis of polyfunctionalized fluoromethyleneketone retroamides as potential inhibitors of thrombin

Tetrahedron letters, 1991-12, Vol.32 (49), p.7255-7258

1991

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Preparative Separation of Mixtures by Mass Spectrometry

Analytical chemistry (Washington), 2005-07, Vol.77 (14), p.4378-4384

2005

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Useful hydroxylamine derivatives for the synthesis of hydroxamic acids

Tetrahedron letters, 1992-08, Vol.33 (35), p.5055-5058

1992

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Synthesis and biological properties of .alpha.-mono and .alpha.-difluoromethyl derivatives of tryptophan and 5-hydroxytryptophan

Journal of medicinal chemistry, 1988-01, Vol.31 (1), p.30-36

1988

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Short and unexpectedly potent difluorostatone type inhibitors of HIV-1 protease

Bioorganic & medicinal chemistry letters, 1993-02, Vol.3 (2), p.253-258

1993

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Trimethylsilylated trifluoromethyl ketones, a novel class of acetylcholinesterase inhibitors: biochemical and pharmacological profile of MDL 73,745

Biochemical Society transactions, 1994-08, Vol.22 (3), p.758-763

1994

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Beneficial replacement of the P 1 phenylalanine side chain in HIV-1 protease inhibitors of the difluorostatone type

Bioorganic & medicinal chemistry letters, 1994-01, Vol.4 (2), p.241-246

1994

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Silicon-Mediated Inactivation of Diamine Oxidase

Bioorganic chemistry, 1996-06, Vol.24 (2), p.178-193

1996

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MDL 74147, a novel selective and soluble inhibitor of human renin. Synthesis, structure-activity relationship, species and protease selectivities

Bioorganic & medicinal chemistry letters, 1992-07, Vol.2 (7), p.651-654

1992

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New fluoroketones as human renin inhibitors

FEBS letters, 1989-05, Vol.249 (1), p.47-50

1989

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Biochemical and pharmacological evaluation of 2,4-difluorobenzyldimethylsilylmethanamine, a new highly selective inhibitor of monoamine oxidase-B

Biochemical Society transactions, 1994-08, Vol.22 (3), p.768-773

1994

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Beneficial replacement of the P1 phenylalanine side chain in HIV-1 protease inhibitors of the difluorostatone type

Bioorganic & medicinal chemistry letters, 1994-01, Vol.4 (2), p.241-246

1994

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A convenient synthesis of α',β-diamino-α,α-difluoroketones, new dipeptide isosteres

Tetrahedron letters, 1988, Vol.29 (30), p.3687-3690

1988

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Increased antiviral activity of HIV protease inhibitors of the difluorostatone type bearing (R)-valinol derivatives as novel c-termini

Bioorganic & medicinal chemistry letters, 1994-05, Vol.4 (10), p.1213-1218

1994

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Selective inactivation of MAO-B by benzyl-dimethyl-silyl-methanamines in vitro

Biochemical and biophysical research communications, 1989-04, Vol.160 (2), p.540-544

1989

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Anti-Human Immunodeficiency Virus Activity, Bioavailability and Drug Resistance Profile of the Novel Proteinase Inhibitor MDL 74,695

Antiviral chemistry & chemotherapy, 1997-06, Vol.8 (3), p.205-214

1997

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General approach to the synthesis of α-difluoromethyl amines as potential enzyme-activated irreversible inhibitors

Tetrahedron letters, 1978, Vol.19 (52), p.5225-5228

1978

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Synthesis of peptidyl fluoromethyl ketones and peptidyl α-keto esters as inhibitors of porcine pancreatic elastase, human neutrophil elastase, and rat and human neutrophil cathepsin G

Journal of medicinal chemistry, 1990, Vol.33 (1), p.394-407

1990

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Synthesis of Crystalline Orthogonally N-Protected (S)- or (R)-2,3-Diaminopropionaldehyde from L- or D-Aspartic Acid

Synthesis (Stuttgart), 1995, Vol.1995 (11), p.1351-1352

1995

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Design, Synthesis, and Conformational Analysis of a Novel Macrocyclic HIV-Protease Inhibitor

Journal of medicinal chemistry, 1994-10, Vol.37 (22), p.3684-3692

1994

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ω‐Fluoromethyl Analogues of ω‐Amino Acids as Irreversible Inhibitors of 4‐Aminobutyrate: 2‐ Oxoglutarate Aminotransferase

Journal of neurochemistry, 1981-11, Vol.37 (5), p.1341-1344

1981

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Synthesis and inhibitory properties of α(chlorofluoromethyl)-α-amino acids, a novel class of irreversible inactivators of decarboxylases

J. Chem. Soc., Perkin Trans. 1, 1992 (8), p.1053-1064

1992

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Rearrangements of the carbanions derived from allyl benzyl thioether

Tetrahedron, 1980, Vol.36 (9), p.1249-1259

1980

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Silicon-mediated inactivation of semicarbazide-sensitive amine oxidase

Bioorganic & medicinal chemistry letters, 1995-10, Vol.5 (20), p.2363-2366

1995

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Difluoromethyleneketone retroamide, a versatile concept of inactivation of proteolytic enzymes

General synthesis of polyfunctionalized fluoromethyleneketone retroamides as potential inhibitors of thrombin

Preparative Separation of Mixtures by Mass Spectrometry

Useful hydroxylamine derivatives for the synthesis of hydroxamic acids

Synthesis and biological properties of .alpha.-mono and .alpha.-difluoromethyl derivatives of tryptophan and 5-hydroxytryptophan

Short and unexpectedly potent difluorostatone type inhibitors of HIV-1 protease

Trimethylsilylated trifluoromethyl ketones, a novel class of acetylcholinesterase inhibitors: biochemical and pharmacological profile of MDL 73,745

Beneficial replacement of the P 1 phenylalanine side chain in HIV-1 protease inhibitors of the difluorostatone type

Silicon-Mediated Inactivation of Diamine Oxidase

MDL 74147, a novel selective and soluble inhibitor of human renin. Synthesis, structure-activity relationship, species and protease selectivities

New fluoroketones as human renin inhibitors

Biochemical and pharmacological evaluation of 2,4-difluorobenzyldimethylsilylmethanamine, a new highly selective inhibitor of monoamine oxidase-B

Beneficial replacement of the P1 phenylalanine side chain in HIV-1 protease inhibitors of the difluorostatone type

A convenient synthesis of α',β-diamino-α,α-difluoroketones, new dipeptide isosteres

Increased antiviral activity of HIV protease inhibitors of the difluorostatone type bearing (R)-valinol derivatives as novel c-termini

Selective inactivation of MAO-B by benzyl-dimethyl-silyl-methanamines in vitro

Anti-Human Immunodeficiency Virus Activity, Bioavailability and Drug Resistance Profile of the Novel Proteinase Inhibitor MDL 74,695

General approach to the synthesis of α-difluoromethyl amines as potential enzyme-activated irreversible inhibitors

Synthesis of peptidyl fluoromethyl ketones and peptidyl α-keto esters as inhibitors of porcine pancreatic elastase, human neutrophil elastase, and rat and human neutrophil cathepsin G

Synthesis of Crystalline Orthogonally N-Protected (S)- or (R)-2,3-Diaminopropionaldehyde from L- or D-Aspartic Acid

Design, Synthesis, and Conformational Analysis of a Novel Macrocyclic HIV-Protease Inhibitor

ω‐Fluoromethyl Analogues of ω‐Amino Acids as Irreversible Inhibitors of 4‐Aminobutyrate: 2‐ Oxoglutarate Aminotransferase

Synthesis and inhibitory properties of α(chlorofluoromethyl)-α-amino acids, a novel class of irreversible inactivators of decarboxylases

Rearrangements of the carbanions derived from allyl benzyl thioether

Silicon-mediated inactivation of semicarbazide-sensitive amine oxidase

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