UB Paderborn / Katalog / Suche / in CDI

Ecological validity of walking capacity tests in multiple sclerosis

PloS one, 2015-04, Vol.10 (4), p.e0123822-e0123822

2015

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GlcNAcstatin: a Picomolar, Selective O-GlcNAcase Inhibitor That Modulates Intracellular O-GlcNAcylation Levels

Journal of the American Chemical Society, 2006-12, Vol.128 (51), p.16484-16485

2006

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The role of chilectins in rheumatoid arthritis

Acta crystallographica. Section A, Foundations of crystallography, 2008-08, Vol.64 (a1), p.C231-C232

2008

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Role of joint damage, malalignment and inflammation in articular tenderness in rheumatoid arthritis, psoriatic arthritis and osteoarthritis

Annals of the rheumatic diseases, 2021-07, Vol.80 (7), p.884

2021

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The Discovery of 7‑Methyl-2-[(7-methyl[1,2,4]triazolo[1,5‑a]pyridin-6-yl)amino]-9-(tetrahydro‑2H‑pyran-4-yl)-7,9-dihydro‑8H‑purin-8-one (AZD7648), a Potent and Selective DNA-Dependent Protein Kinase (DNA-PK) Inhibitor

Journal of medicinal chemistry, 2020-04, Vol.63 (7), p.3461-3471

2020

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Regulation of Caenorhabditis elegans p53/CEP-1-dependent germ cell apoptosis by Ras/MAPK signaling

PLoS genetics, 2011-08, Vol.7 (8), p.e1002238

2011

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Bisubstrate UDP-peptide conjugates as human O-GlcNAc transferase inhibitors

Biochemical journal, 2014-02, Vol.457 (3), p.497-502

2014

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The Discovery of 7-Methyl-2-[(7-methyl[1,2,4]triazolo[1,5- a ]pyridin-6-yl)amino]-9-(tetrahydro-2 H -pyran-4-yl)-7,9-dihydro-8 H -purin-8-one (AZD7648), a Potent and Selective DNA-Dependent Protein Kinase (DNA-PK) Inhibitor

Journal of medicinal chemistry, 2020-04, Vol.63 (7), p.3461-3471

2020

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O-GlcNAcase: Promiscuous Hexosaminidase or Key Regulator of O-GlcNAc Signaling?

The Journal of biological chemistry, 2014-12, Vol.289 (50), p.34433-34439

2014

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Dynamics of the HD regulatory subdomain of PARP-1; substrate access and allostery in PARP activation and inhibition

Nucleic acids research, 2021-02, Vol.49 (4), p.2266

2021

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The active site of O-GlcNAc transferase imposes constraints on substrate sequence

Nature structural & molecular biology, 2015-09, Vol.22 (9), p.744

2015

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Alkynyl Benzoxazines and Dihydroquinazolines as Cysteine Targeting Covalent Warheads and Their Application in Identification of Selective Irreversible Kinase Inhibitors

Journal of the American Chemical Society, 2020-06, Vol.142 (23), p.10358-10372

2020

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Discovery of 5-{4-[(7-Ethyl-6-oxo-5,6-dihydro-1,5-naphthyridin-3-yl)methyl]piperazin-1-yl}- N -methylpyridine-2-carboxamide (AZD5305): A PARP1-DNA Trapper with High Selectivity for PARP1 over PARP2 and Other PARPs

Journal of medicinal chemistry, 2021-10, Vol.64 (19), p.14498-14512

2021

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Discovery of a Potent and Selective ATAD2 Bromodomain Inhibitor with Antiproliferative Activity in Breast Cancer Models

Journal of medicinal chemistry, 2022-02, Vol.65 (4), p.3306-3331

2022

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A-loop interactions in Mer tyrosine kinase give rise to inhibitors with two-step mechanism and long residence time of binding

Biochemical journal, 2020-11, Vol.477 (22), p.4443-4452

2020

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Fragment-Based Design of a Potent MAT2a Inhibitor and in Vivo Evaluation in an MTAP Null Xenograft Model

Journal of medicinal chemistry, 2021-05, Vol.64 (10), p.6814-6826

2021

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O-GlcNAc transferase invokes nucleotide sugar pyrophosphate participation in catalysis

Nature chemical biology, 2012-12, Vol.8 (12), p.969

2012

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Control of T cell hyperactivation in IL‐2‐deficient mice by CD4+CD25– and CD4+CD25+ T cells: evidence for two distinct regulatory mechanisms

European journal of immunology, 2001-06, Vol.31 (6), p.1637-1645

2001

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Development of a Series of Pyrrolopyridone MAT2A Inhibitors

Journal of medicinal chemistry, 2024-03, Vol.67 (6), p.4541-4559

2024

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Nitrogen Binding to the FeMo-Cofactor of Nitrogenase

Journal of the American Chemical Society, 2003-12, Vol.125 (51), p.15772-15778

2003

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Loss of CRMP2 O-GlcNAcylation leads to reduced novel object recognition performance in mice

Open biology, 2019-11, Vol.9 (11), p.190192-190192

2019

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Optimization of an Imidazo[1,2‑a]pyridine Series to Afford Highly Selective Type I1/2 Dual Mer/Axl Kinase Inhibitors with In Vivo Efficacy

Journal of medicinal chemistry, 2021-09, Vol.64 (18), p.13524-13539

2021

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Generating Selective Leads for Mer Kinase InhibitorsExample of a Comprehensive Lead-Generation Strategy

Journal of medicinal chemistry, 2021-03, Vol.64 (6), p.3165-3184

2021

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Ecological validity of walking capacity tests in multiple sclerosis

GlcNAcstatin: a Picomolar, Selective O-GlcNAcase Inhibitor That Modulates Intracellular O-GlcNAcylation Levels

The role of chilectins in rheumatoid arthritis

Role of joint damage, malalignment and inflammation in articular tenderness in rheumatoid arthritis, psoriatic arthritis and osteoarthritis

The Discovery of 7‑Methyl-2-[(7-methyl[1,2,4]triazolo[1,5‑a]pyridin-6-yl)amino]-9-(tetrahydro‑2H‑pyran-4-yl)-7,9-dihydro‑8H‑purin-8-one (AZD7648), a Potent and Selective DNA-Dependent Protein Kinase (DNA-PK) Inhibitor

Regulation of Caenorhabditis elegans p53/CEP-1-dependent germ cell apoptosis by Ras/MAPK signaling

Bisubstrate UDP-peptide conjugates as human O-GlcNAc transferase inhibitors

The Discovery of 7-Methyl-2-[(7-methyl[1,2,4]triazolo[1,5- a ]pyridin-6-yl)amino]-9-(tetrahydro-2 H -pyran-4-yl)-7,9-dihydro-8 H -purin-8-one (AZD7648), a Potent and Selective DNA-Dependent Protein Kinase (DNA-PK) Inhibitor

O-GlcNAcase: Promiscuous Hexosaminidase or Key Regulator of O-GlcNAc Signaling?

Dynamics of the HD regulatory subdomain of PARP-1; substrate access and allostery in PARP activation and inhibition

The active site of O-GlcNAc transferase imposes constraints on substrate sequence

Alkynyl Benzoxazines and Dihydroquinazolines as Cysteine Targeting Covalent Warheads and Their Application in Identification of Selective Irreversible Kinase Inhibitors

Discovery of 5-{4-[(7-Ethyl-6-oxo-5,6-dihydro-1,5-naphthyridin-3-yl)methyl]piperazin-1-yl}- N -methylpyridine-2-carboxamide (AZD5305): A PARP1-DNA Trapper with High Selectivity for PARP1 over PARP2 and Other PARPs

Discovery of a Potent and Selective ATAD2 Bromodomain Inhibitor with Antiproliferative Activity in Breast Cancer Models

A-loop interactions in Mer tyrosine kinase give rise to inhibitors with two-step mechanism and long residence time of binding

Fragment-Based Design of a Potent MAT2a Inhibitor and in Vivo Evaluation in an MTAP Null Xenograft Model

O-GlcNAc transferase invokes nucleotide sugar pyrophosphate participation in catalysis

Control of T cell hyperactivation in IL‐2‐deficient mice by CD4+CD25– and CD4+CD25+ T cells: evidence for two distinct regulatory mechanisms

Discovery of N‑(4-{[5-Fluoro-7-(2-methoxyethoxy)quinazolin-4-yl]amino}phenyl)-2-[4-(propan-2-yl)‑1H‑1,2,3-triazol-1-yl]acetamide (AZD3229), a Potent Pan-KIT Mutant Inhibitor for the Treatment of Gastrointestinal Stromal Tumors

Development of a Series of Pyrrolopyridone MAT2A Inhibitors

Nitrogen Binding to the FeMo-Cofactor of Nitrogenase

Loss of CRMP2 O-GlcNAcylation leads to reduced novel object recognition performance in mice

Optimization of an Imidazo[1,2‑a]pyridine Series to Afford Highly Selective Type I1/2 Dual Mer/Axl Kinase Inhibitors with In Vivo Efficacy

Generating Selective Leads for Mer Kinase InhibitorsExample of a Comprehensive Lead-Generation Strategy

Discovery, Optimization, and Biological Evaluation of Arylpyridones as Cbl‑b Inhibitors

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