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Revisiting a Classic Approach to the Aspidosperma Alkaloids: An Intramolecular Schmidt Reaction Mediated Synthesis of (+)-Aspidospermidine

Journal of organic chemistry, 2005-12, Vol.70 (26), p.10645-10652

2005

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Investigation of metabolism and disposition of Pf-05212377: Unexpected sulfonamide hydrolysis explains the lack of ketoconazole mediated DDI

Drug metabolism and pharmacokinetics, 2017-01, Vol.32 (1), p.S52-S52

2017

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Regiocontrol in an Intramolecular Schmidt Reaction: Total Synthesis of (+)-Aspidospermidine

Organic letters, 2000-06, Vol.2 (11), p.1625-1627

2000

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Genotoxicity of 2-(3-chlorobenzyloxy)-6-(piperazinyl)pyrazine, a novel 5-hydroxytryptamine2c receptor agonist for the treatment of obesity: role of metabolic activation

Drug metabolism and disposition, 2007-06, Vol.35 (6), p.848

2007

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Reactions of Alkyl Azides and Ketones as Mediated by Lewis Acids: Schmidt and Mannich Reactions Using Azide Precursors

Journal of the American Chemical Society, 2000-08, Vol.122 (30), p.7226-7232

2000

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Identification and Development of an Irreversible Monoacylglycerol Lipase (MAGL) Positron Emission Tomography (PET) Radioligand with High Specificity

Journal of medicinal chemistry, 2019-09, Vol.62 (18), p.8532-8543

2019

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Determination of Antibody–Drug Conjugate Released Payload Species Using Directed in Vitro Assays and Mass Spectrometric Interrogation

Bioconjugate chemistry, 2016-07, Vol.27 (7), p.1645-1654

2016

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Deuterium isotope effects on drug pharmacokinetics. I. System-dependent effects of specific deuteration with aldehyde oxidase cleared drugs

Drug metabolism and disposition, 2012-03, Vol.40 (3), p.625

2012

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Metabolism of a 5HT^sub 6^ Antagonist, 2-Methyl-1-(Phenylsulfonyl)-4-(Piperazin-1-yl)-1H-Benzo[d]imidazole (SAM-760): Impact of Sulfonamide Metabolism on Diminution of a Ketoconazole-Mediated Clinical Drug-Drug Interaction

Drug metabolism and disposition, 2018-07, Vol.46 (7), p.934

2018

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Metabolism of a 5HT 6 Antagonist, 2-Methyl-1-(Phenylsulfonyl)-4-(Piperazin-1-yl)-1H-Benzo[d]imidazole (SAM-760): Impact of Sulfonamide Metabolism on Diminution of a Ketoconazole-Mediated Clinical Drug-Drug Interaction

Drug metabolism and disposition, 2018-07, Vol.46 (7), p.934-942

2018

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Identification of a Novel Positron Emission Tomography (PET) Ligand for Imaging β‑Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE-1) in Brain

Journal of medicinal chemistry, 2018-04, Vol.61 (8), p.3296-3308

2018

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THE METABOLISM OF LUFOTRELVIR, A PRODRUG INVESTIGATED FOR THE TREATMENT OF SARS-COV-2, IN HUMANS FOLLOWING INTRAVENOUS ADMINISTRATION

Drug metabolism and disposition, 2023-07

2023

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Deuterated active pharmaceutical ingredients: A science‐based proposal for synthesis, analysis, and control. Part 1: Framing the problem

Journal of labelled compounds & radiopharmaceuticals, 2019-09, Vol.62 (11), p.690-694

2019

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Metabolism of a 5HT6 antagonist, 2-methyl-1-(phenylsulfonyl)-4-(piperazin-1-yl)-1H-benzo[d]imidazole (SAM-760): impact of sulfonamide metabolism on diminution of a ketoconazole mediated clinical drug-drug interaction

Drug metabolism and disposition, 2018-07, Vol.46 (7), p.934-942

2018

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Novel Application of the Two‐Period Microtracer Approach to Determine Absolute Oral Bioavailability and Fraction Absorbed of Ertugliflozin

Clinical and translational science, 2018-07, Vol.11 (4), p.405-411

2018

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10th international symposium on the synthesis and applications of isotopes and isotopically labelled compounds-applications of isotopes in organic and bioorganic reaction mechanisms Session 4, Wednesday, June 17, 2009

Journal of labelled compounds & radiopharmaceuticals, 2010-05, Vol.53 (5-6), p.275-282

2010

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Identification and Profiling of a Selective and Brain Penetrant Radioligand for in Vivo Target Occupancy Measurement of Casein Kinase 1 (CK1) Inhibitors

ACS chemical neuroscience, 2017-09, Vol.8 (9), p.1995-2004

2017

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Poster #S45 DEVELOPMENT OF NOVEL PET LIGANDS (PF-04831704 AND PF-06327104) FOR PDE10A

Schizophrenia research, 2014-04, Vol.153, p.S104-S105

2014

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Asymmetric syntheses of radioactive and stable isotope-labeled β-amino acids

Journal of labelled compounds & radiopharmaceuticals, 2012-05, Vol.55 (5), p.166-170

2012

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An efficient large‐scale synthesis of 1 H ‐indazole‐[3‐ 14 C]carboxylic acid

Journal of labelled compounds & radiopharmaceuticals, 2007-06, Vol.50 (7), p.675-678

2007

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Inter- and Intramolecular Addition/Cyclizations of Sulfonamide Anions with Alkynyliodonium Triflates. Synthesis of Dihydropyrrole, Pyrrole, Indole, and Tosylenamide Heterocycles

Journal of organic chemistry, 1996-08, Vol.61 (16), p.5440-5452

1996

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An efficient large-scale synthesis of 1H-indazole-[3-14C]carboxylic acid

Journal of labelled compounds & radiopharmaceuticals, 2007-06, Vol.50 (7), p.675-678

2007

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Mannich reactions using benzyl azide as a latent N-(phenylamino)methylating agent

Tetrahedron letters, 1998-10, Vol.39 (42), p.7687-7690

1998

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Metabolism, pharmacokinetics, and excretion of the 5-hydroxytryptamine1b receptor antagonist elzasonan in humans

Drug metabolism and disposition, 2010-11, Vol.38 (11), p.1984

2010

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Intramolecular Bicyclizations of Tosylamide-Containing Alkynyliodonium Salts as an Efficient Entry into Polycyclic Alkaloid Skeleta

Journal of the American Chemical Society, 1995-07, Vol.117 (28), p.7544-7545

1995

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Revisiting a Classic Approach to the Aspidosperma Alkaloids: An Intramolecular Schmidt Reaction Mediated Synthesis of (+)-Aspidospermidine

Investigation of metabolism and disposition of Pf-05212377: Unexpected sulfonamide hydrolysis explains the lack of ketoconazole mediated DDI

Regiocontrol in an Intramolecular Schmidt Reaction: Total Synthesis of (+)-Aspidospermidine

Genotoxicity of 2-(3-chlorobenzyloxy)-6-(piperazinyl)pyrazine, a novel 5-hydroxytryptamine2c receptor agonist for the treatment of obesity: role of metabolic activation

Reactions of Alkyl Azides and Ketones as Mediated by Lewis Acids: Schmidt and Mannich Reactions Using Azide Precursors

Identification and Development of an Irreversible Monoacylglycerol Lipase (MAGL) Positron Emission Tomography (PET) Radioligand with High Specificity

Determination of Antibody–Drug Conjugate Released Payload Species Using Directed in Vitro Assays and Mass Spectrometric Interrogation

Deuterium isotope effects on drug pharmacokinetics. I. System-dependent effects of specific deuteration with aldehyde oxidase cleared drugs

Metabolism of a 5HT^sub 6^ Antagonist, 2-Methyl-1-(Phenylsulfonyl)-4-(Piperazin-1-yl)-1H-Benzo[d]imidazole (SAM-760): Impact of Sulfonamide Metabolism on Diminution of a Ketoconazole-Mediated Clinical Drug-Drug Interaction

Metabolism of a 5HT 6 Antagonist, 2-Methyl-1-(Phenylsulfonyl)-4-(Piperazin-1-yl)-1H-Benzo[d]imidazole (SAM-760): Impact of Sulfonamide Metabolism on Diminution of a Ketoconazole-Mediated Clinical Drug-Drug Interaction

Identification of a Novel Positron Emission Tomography (PET) Ligand for Imaging β‑Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE-1) in Brain

THE METABOLISM OF LUFOTRELVIR, A PRODRUG INVESTIGATED FOR THE TREATMENT OF SARS-COV-2, IN HUMANS FOLLOWING INTRAVENOUS ADMINISTRATION

Deuterated active pharmaceutical ingredients: A science‐based proposal for synthesis, analysis, and control. Part 1: Framing the problem

Metabolism of a 5HT6 antagonist, 2-methyl-1-(phenylsulfonyl)-4-(piperazin-1-yl)-1H-benzo[d]imidazole (SAM-760): impact of sulfonamide metabolism on diminution of a ketoconazole mediated clinical drug-drug interaction

Novel Application of the Two‐Period Microtracer Approach to Determine Absolute Oral Bioavailability and Fraction Absorbed of Ertugliflozin

10th international symposium on the synthesis and applications of isotopes and isotopically labelled compounds-applications of isotopes in organic and bioorganic reaction mechanisms Session 4, Wednesday, June 17, 2009

Identification and Profiling of a Selective and Brain Penetrant Radioligand for in Vivo Target Occupancy Measurement of Casein Kinase 1 (CK1) Inhibitors

Poster #S45 DEVELOPMENT OF NOVEL PET LIGANDS (PF-04831704 AND PF-06327104) FOR PDE10A

Asymmetric syntheses of radioactive and stable isotope-labeled β-amino acids

An efficient large‐scale synthesis of 1 H ‐indazole‐[3‐ 14 C]carboxylic acid

Inter- and Intramolecular Addition/Cyclizations of Sulfonamide Anions with Alkynyliodonium Triflates. Synthesis of Dihydropyrrole, Pyrrole, Indole, and Tosylenamide Heterocycles

An efficient large-scale synthesis of 1H-indazole-[3-14C]carboxylic acid

Mannich reactions using benzyl azide as a latent N-(phenylamino)methylating agent

Metabolism, pharmacokinetics, and excretion of the 5-hydroxytryptamine1b receptor antagonist elzasonan in humans

Intramolecular Bicyclizations of Tosylamide-Containing Alkynyliodonium Salts as an Efficient Entry into Polycyclic Alkaloid Skeleta

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