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5-Cyanopyrimidine Derivatives as a Novel Class of Potent, Selective, and Orally Active Inhibitors of p38α MAP Kinase

Journal of medicinal chemistry, 2005-10, Vol.48 (20), p.6261-6270

2005

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7,12-Dimethylbenz[a]anthracene activates protein-tyrosine kinases Fyn and Lck in the HPB-ALL human T-cell line and increases tyrosine phosphorylation of phospholipase C-gamma 1, formation of inositol 1,4,5-trisphosphate, and mobilization of intracellular calcium

Proceedings of the National Academy of Sciences - PNAS, 1993-07, Vol.90 (13), p.6105-6109

1993

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Accessory receptors regulate coupling of the T-cell receptor complex to tyrosine kinase activation and mobilization of cytoplasmic calcium in T- lineage acute lymphoblastic leukemia

Blood, 1991-03, Vol.77 (6), p.1271-1282

1991

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Accessory Receptors Regulate Coupling of the T-Cell Receptor Complex to Tyrosine Kinase Activation and Mobilization of Cytoplasmic Calcium in T-Lineage Acute Lymphoblastic Leukemia

Blood, 1991-03, Vol.77 (6), p.1271-1282

1991

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Activation of tyrosine kinase signal pathways by radiation and oxidative stress

Trends in Endocrinology & Metabolism, 1994-11, Vol.5 (9), p.383-388

1994

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Amino acid sequence of the nonsecretory ribonuclease of human urine

Biochemistry (Easton), 1988-06, Vol.27 (12), p.4530-4538

1988

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Association of 75/80-kDa phosphoproteins and the tyrosine kinases Lyn, Fyn, and Lck with the B cell molecule CD20. Evidence against involvement of the cytoplasmic regions of CD20

The Journal of biological chemistry, 1995-09, Vol.270 (38), p.22632-22638

1995

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Association of tyrosine and serine kinases with the B cell surface antigen CD20. Induction via CD20 of tyrosine phosphorylation and activation of phospholipase C-gamma 1 and PLC phospholipase C-gamma 2

The Journal of immunology (1950), 1993-11, Vol.151 (9), p.4494-4504

1993

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The biology of p38 kinase: a central role in inflammation

Current topics in medicinal chemistry, 2005-09, Vol.5 (10), p.921-928

Schieven, Gary L

2005

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CD28 Ligation in T-Cell Activation: Evidence for Two Signal Transduction Pathways

Blood, 1990-04, Vol.75 (7), p.1531-1539

1990

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CD28 ligation in T-cell activation: evidence for two signal transduction pathways

Blood, 1990-04, Vol.75 (7), p.1531-1539

1990

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CD4 and CD8 are positive regulators of T cell receptor signal transduction in early T cell differentiation

The Journal of immunology (1950), 1991-03, Vol.146 (6), p.1759-1765

1991

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CD4 and CD8 T cells from SIV-infected macaques have defective signaling responses after perturbation of either CD3 or CD2 receptors

International immunology, 1990, Vol.2 (9), p.849-858

1990

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CD4, CD8 and the role of CD45 in T-cell activation

Current opinion in immunology, 1993-06, Vol.5 (3), p.334-340

1993

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CD45 cross-linking regulates phospholipase C activation and tyrosine phosphorylation of specific substrates in CD3/Ti-stimulated T cells

The Journal of immunology (1950), 1991-03, Vol.146 (5), p.1577-1583

1991

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CD45 ligation in T cells regulates signal transduction through both the interleukin-2 receptor and the CD3/Ti T-cell receptor complex

Tissue antigens, 1990-03, Vol.35 (3), p.128-135

1990

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CD45-mediated regulation of extracellular calcium influx in a CD4-transfected human T cell line

The Journal of immunology (1950), 1994-07, Vol.153 (1), p.84-96

1994

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CD45 modulates T cell receptor/CD3‐induced activation of human thymocytes via regulation of tyrosine phosphorylation

European journal of immunology, 1992-02, Vol.22 (2), p.551-557

1992

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Cloning and Expression of the Tumor-Associated Antigen L6

Proceedings of the National Academy of Sciences - PNAS, 1992-04, Vol.89 (8), p.3503-3507

1992

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Collagen stimulates tyrosine phosphorylation of phospholipase C-gamma 2 but not phospholipase C-gamma 1 in human platelets

FEBS letters, 1994-10, Vol.353 (2), p.212-216

1994

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Cross-linking of Fc gamma receptor I (Fc gamma RI) and receptor II (Fc gamma RII) on monocytic cells activates a signal transduction pathway common to both Fc receptors that involves the stimulation of p72 Syk protein tyrosine kinase

The Journal of biological chemistry, 1993-11, Vol.268 (32), p.24442-24448

1993

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CS observations of L1551: no rotating disk

The Astrophysical journal, 1987-06, Vol.317 (2), p.L95-L99

1987

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Developmental regulation of pp44/46, tyrosine-phosphorylated proteins associated with tyrosine/serine kinase activity in Trypanosoma brucei

Molecular and biochemical parasitology, 1994, Vol.63 (1), p.69-78

1994

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Differences in glycosylation pattern of human secretory ribonucleases

Biochemical journal, 1988-10, Vol.255 (2), p.501-505

1988

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Discovery and initial SAR of 2-amino-5-carboxamidothiazoles as inhibitors of the Src-family kinase p56(Lck)

Bioorganic & medicinal chemistry letters, 2003-11, Vol.13 (22), p.4007-4010

2003

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5-Cyanopyrimidine Derivatives as a Novel Class of Potent, Selective, and Orally Active Inhibitors of p38α MAP Kinase

7,12-Dimethylbenz[a]anthracene activates protein-tyrosine kinases Fyn and Lck in the HPB-ALL human T-cell line and increases tyrosine phosphorylation of phospholipase C-gamma 1, formation of inositol 1,4,5-trisphosphate, and mobilization of intracellular calcium

Accessory receptors regulate coupling of the T-cell receptor complex to tyrosine kinase activation and mobilization of cytoplasmic calcium in T- lineage acute lymphoblastic leukemia

Accessory Receptors Regulate Coupling of the T-Cell Receptor Complex to Tyrosine Kinase Activation and Mobilization of Cytoplasmic Calcium in T-Lineage Acute Lymphoblastic Leukemia

Activation of tyrosine kinase signal pathways by radiation and oxidative stress

Amino acid sequence of the nonsecretory ribonuclease of human urine

Association of 75/80-kDa phosphoproteins and the tyrosine kinases Lyn, Fyn, and Lck with the B cell molecule CD20. Evidence against involvement of the cytoplasmic regions of CD20

Association of tyrosine and serine kinases with the B cell surface antigen CD20. Induction via CD20 of tyrosine phosphorylation and activation of phospholipase C-gamma 1 and PLC phospholipase C-gamma 2

The biology of p38 kinase: a central role in inflammation

CD28 Ligation in T-Cell Activation: Evidence for Two Signal Transduction Pathways

CD28 ligation in T-cell activation: evidence for two signal transduction pathways

CD4 and CD8 are positive regulators of T cell receptor signal transduction in early T cell differentiation

CD4 and CD8 T cells from SIV-infected macaques have defective signaling responses after perturbation of either CD3 or CD2 receptors

CD4, CD8 and the role of CD45 in T-cell activation

CD45 cross-linking regulates phospholipase C activation and tyrosine phosphorylation of specific substrates in CD3/Ti-stimulated T cells

CD45 ligation in T cells regulates signal transduction through both the interleukin-2 receptor and the CD3/Ti T-cell receptor complex

CD45-mediated regulation of extracellular calcium influx in a CD4-transfected human T cell line

CD45 modulates T cell receptor/CD3‐induced activation of human thymocytes via regulation of tyrosine phosphorylation

Cloning and Expression of the Tumor-Associated Antigen L6

Collagen stimulates tyrosine phosphorylation of phospholipase C-gamma 2 but not phospholipase C-gamma 1 in human platelets

Cross-linking of Fc gamma receptor I (Fc gamma RI) and receptor II (Fc gamma RII) on monocytic cells activates a signal transduction pathway common to both Fc receptors that involves the stimulation of p72 Syk protein tyrosine kinase

CS observations of L1551: no rotating disk

Developmental regulation of pp44/46, tyrosine-phosphorylated proteins associated with tyrosine/serine kinase activity in Trypanosoma brucei

Differences in glycosylation pattern of human secretory ribonucleases

Discovery and initial SAR of 2-amino-5-carboxamidothiazoles as inhibitors of the Src-family kinase p56(Lck)

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