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Evolution by innovation as a driving force to improve TCR-T therapies

Frontiers in oncology, 2023-09, Vol.13, p.1216829-1216829

Schendel, Dolores J.

2023

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Pharmacologic Inhibition of MALT1 Protease by Phenothiazines as a Therapeutic Approach for the Treatment of Aggressive ABC-DLBCL

Cancer cell, 2012-12, Vol.22 (6), p.825-837

2012

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CXC Chemokine Receptor 4 is Essential for Maintenance of Renal cell Carcinoma‐Initiating Cells and Predicts Metastasis

Stem cells (Dayton, Ohio), 2013-08, Vol.31 (8), p.1467-1476

2013

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Machine Learning for Cancer Immunotherapies Based on Epitope Recognition by T Cell Receptors

Frontiers in genetics, 2019-11, Vol.10, p.1141-1141

2019

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Identifying baseline immune-related biomarkers to predict clinical outcome of immunotherapy

Journal for Immunotherapy of Cancer, 2017-05, Vol.5 (1), p.44-44, Article 44

2017

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Expitope 2.0: a tool to assess immunotherapeutic antigens for their potential cross-reactivity against naturally expressed proteins in human tissues

BMC cancer, 2017-12, Vol.17 (1), p.892-892, Article 892

2017

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T-Cells Expressing a Highly Potent PRAME-Specific T-Cell Receptor in Combination with a Chimeric PD1-41BB Co-Stimulatory Receptor Show a Favorable Preclinical Safety Profile and Strong Anti-Tumor Reactivity

Cancers, 2022-04, Vol.14 (8), p.1998

2022

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A novel and effective method to generate human porcine-specific regulatory T cells with high expression of IL-10, TGF-β1 and IL-35

Scientific reports, 2017-06, Vol.7 (1), p.3974-13, Article 3974

2017

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Graft-versus-leukemia reactions in allogeneic chimeras

Blood, 2004-02, Vol.103 (3), p.767-776

2004

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CD86 and IL-12p70 are key players for T helper 1 polarization and natural killer cell activation by Toll-like receptor-induced dendritic cells

PloS one, 2012-09, Vol.7 (9), p.e44266-e44266

2012

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Generation of Th1-polarizing dendritic cells using the TLR7/8 agonist CL075

The Journal of immunology (1950), 2010-07, Vol.185 (1), p.738-747

2010

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Generation of clinical grade dendritic cells with capacity to produce biologically active IL-12p70

Journal of translational medicine, 2007-04, Vol.5 (1), p.18-18, Article 18

2007

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Development of a CD8 co-receptor independent T-cell receptor specific for tumor-associated antigen MAGE-A4 for next generation T-cell-based immunotherapy

Journal for immunotherapy of cancer, 2021-03, Vol.9 (3), p.e002035

2021

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Decreased cord blood IL-4, IL-13, and CCR4 and increased TGF-β levels after fish oil supplementation of pregnant women

Journal of allergy and clinical immunology, 2008-02, Vol.121 (2), p.464-470.e6

2008

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Codon optimization of the human papillomavirus E7 oncogene induces a CD8+ T cell response to a cryptic epitope not harbored by wild-type E7

PloS one, 2015-03, Vol.10 (3), p.e0121633-e0121633

2015

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Systemic antitumor effect by regional hyperthermia combined with low-dose chemotherapy and immunologic correlates in an adolescent patient with rhabdomyosarcoma - a case report

International journal of hyperthermia, 2020-01, Vol.37 (1), p.55-65

2020

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Cytotoxic Markers and Frequency Predict Functional Capacity of Natural Killer Cells Infiltrating Renal Cell Carcinoma

Clinical cancer research, 2006-02, Vol.12 (3), p.718-725

2006

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Three-day dendritic cells for vaccine development: antigen uptake, processing and presentation

Journal of translational medicine, 2010-09, Vol.8 (1), p.90-90, Article 90

2010

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Designer T cells by T cell receptor replacement

European Journal of Immunology, 2006-11, Vol.36 (11), p.3052-3059

2006

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Effects of TLR agonists on maturation and function of 3-day dendritic cells from AML patients in complete remission

Journal of translational medicine, 2011-09, Vol.9 (1), p.151-151, Article 151

2011

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Toll‐like receptor 7/8‐matured RNA‐transduced dendritic cells as post‐remission therapy in acute myeloid leukaemia: results of a phase I trial

Clinical & translational immunology, 2020, Vol.9 (3), p.e1117-n/a

2020

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Identification of human T-cell receptors with optimal affinity to cancer antigens using antigen-negative humanized mice

Nature biotechnology, 2015-04, Vol.33 (4), p.402-407

2015

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Limitations for TCR gene therapy by MHC-restricted fratricide and TCR-mediated hematopoietic stem cell toxicity

Oncoimmunology, 2013-01, Vol.2 (1), p.0-1

2013

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Assessment of cancer and virus antigens for cross-reactivity in human tissues

Bioinformatics (Oxford, England), 2017-01, Vol.33 (1), p.104-111

2017

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Evolution by innovation as a driving force to improve TCR-T therapies

Pharmacologic Inhibition of MALT1 Protease by Phenothiazines as a Therapeutic Approach for the Treatment of Aggressive ABC-DLBCL

CXC Chemokine Receptor 4 is Essential for Maintenance of Renal cell Carcinoma‐Initiating Cells and Predicts Metastasis

Machine Learning for Cancer Immunotherapies Based on Epitope Recognition by T Cell Receptors

Identifying baseline immune-related biomarkers to predict clinical outcome of immunotherapy

Expitope 2.0: a tool to assess immunotherapeutic antigens for their potential cross-reactivity against naturally expressed proteins in human tissues

T-Cells Expressing a Highly Potent PRAME-Specific T-Cell Receptor in Combination with a Chimeric PD1-41BB Co-Stimulatory Receptor Show a Favorable Preclinical Safety Profile and Strong Anti-Tumor Reactivity

A novel and effective method to generate human porcine-specific regulatory T cells with high expression of IL-10, TGF-β1 and IL-35

Graft-versus-leukemia reactions in allogeneic chimeras

CD86 and IL-12p70 are key players for T helper 1 polarization and natural killer cell activation by Toll-like receptor-induced dendritic cells

Generation of Th1-polarizing dendritic cells using the TLR7/8 agonist CL075

Generation of clinical grade dendritic cells with capacity to produce biologically active IL-12p70

Development of a CD8 co-receptor independent T-cell receptor specific for tumor-associated antigen MAGE-A4 for next generation T-cell-based immunotherapy

Decreased cord blood IL-4, IL-13, and CCR4 and increased TGF-β levels after fish oil supplementation of pregnant women

Codon optimization of the human papillomavirus E7 oncogene induces a CD8+ T cell response to a cryptic epitope not harbored by wild-type E7

Systemic antitumor effect by regional hyperthermia combined with low-dose chemotherapy and immunologic correlates in an adolescent patient with rhabdomyosarcoma - a case report

Cytotoxic Markers and Frequency Predict Functional Capacity of Natural Killer Cells Infiltrating Renal Cell Carcinoma

Three-day dendritic cells for vaccine development: antigen uptake, processing and presentation

Designer T cells by T cell receptor replacement

Effects of TLR agonists on maturation and function of 3-day dendritic cells from AML patients in complete remission

Toll‐like receptor 7/8‐matured RNA‐transduced dendritic cells as post‐remission therapy in acute myeloid leukaemia: results of a phase I trial

Identification of human T-cell receptors with optimal affinity to cancer antigens using antigen-negative humanized mice

Limitations for TCR gene therapy by MHC-restricted fratricide and TCR-mediated hematopoietic stem cell toxicity

Assessment of cancer and virus antigens for cross-reactivity in human tissues

Cancer regression and neurological toxicity following anti-MAGE-A3 TCR gene therapy

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