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Methylglyoxal, a Highly Reactive Dicarbonyl Compound, in Diabetes, Its Vascular Complications, and Other Age-Related Diseases

Physiological reviews, 2020-01, Vol.100 (1), p.407-461

2020

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Current therapeutic interventions in the glycation pathway: evidence from clinical studies

Diabetes, obesity & metabolism, 2013-08, Vol.15 (8), p.677-689

2013

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Abdominal subcutaneous and visceral adipocyte size, lipolysis and inflammation relate to insulin resistance in male obese humans

Scientific reports, 2018-03, Vol.8 (1), p.4677-8, Article 4677

2018

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Effects of rosuvastatin and atorvastatin on glycaemic control in Type 2 diabetes-the CORALL study

Diabetic medicine, 2012-05, Vol.29 (5), p.628-631

2012

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Increased accumulation of the advanced glycation endproduct Ne(carboxymethyl) lysine in the intramyocardial vasculature in patients with epicarditis

International journal of experimental pathology, 2024-04, Vol.105 (2), p.48-51

2024

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Hyperglycaemia-induced impairment of endothelium-dependent vasorelaxation in rat mesenteric arteries is mediated by intracellular methylglyoxal levels in a pathway dependent on oxidative stress

Diabetologia, 2010-05, Vol.53 (5), p.989-1000

2010

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Markers of inflammation are cross-sectionally associated with microvascular complications and cardiovascular disease in type 1 diabetes: the EURODIAB prospective complications study

Diabetologia, 2005-02, Vol.48 (2), p.370-378

2005

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Long‐term effects of metformin on endothelial function in type 2 diabetes: a randomized controlled trial

Journal of internal medicine, 2014-01, Vol.275 (1), p.59-70

2014

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Obesity-associated low-grade inflammation in type 2 diabetes mellitus: causes and consequences

Netherlands journal of medicine, 2013-05, Vol.71 (4), p.174-187

2013

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Serum levels of autoantibodies against the angiotensin II type I receptor are not associated with serum dicarbonyl or AGE levels in patients with an aldosterone-producing adenoma

Journal of human hypertension, 2023-10, Vol.37 (10), p.919-924

2023

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Endothelial dysfunction is associated with a greater depressive symptom score in a general elderly population: the Hoorn Study

Psychological medicine, 2014-05, Vol.44 (7), p.1403-1416

2014

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Associations of Advanced Glycation End-Products With Cognitive Functions in Individuals With and Without Type 2 Diabetes: The Maastricht Study

The journal of clinical endocrinology and metabolism, 2015-03, Vol.100 (3), p.951-960

2015

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Plasma matrix metalloproteinases are associated with incident cardiovascular disease and all-cause mortality in patients with type 1 diabetes: a 12-year follow-up study

Cardiovascular diabetology, 2017-04, Vol.16 (1), p.55-55, Article 55

2017

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Plasma proprotein convertase subtilisin kexin type 9 is not altered in subjects with impaired glucose metabolism and type 2 diabetes mellitus, but its relationship with non-HDL cholesterol and apolipoprotein B may be modified by type 2 diabetes mellitus: The CODAM study

Atherosclerosis, 2011-07, Vol.217 (1), p.263-267

2011

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The journey of adult psoriasis patients towards biologics: past and present ‐ Results from the BioCAPTURE registry

Journal of the European Academy of Dermatology and Venereology, 2018-04, Vol.32 (4), p.615-623

2018

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Protection against methylglyoxal-derived AGEs by regulation of glyoxalase 1 prevents retinal neuroglial and vasodegenerative pathology

Diabetologia, 2012-03, Vol.55 (3), p.845-854

2012

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Effects of short‐term treatment with metformin on markers of endothelial function and inflammatory activity in type 2 diabetes mellitus: a randomized, placebo‐controlled trial

Journal of internal medicine, 2005-01, Vol.257 (1), p.100-109

2005

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Alcohol and red wine consumption, but not fruit, vegetables, fish or dairy products, are associated with less endothelial dysfunction and less low-grade inflammation: the Hoorn Study

European journal of nutrition, 2018-06, Vol.57 (4), p.1409-1419

2018

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Fasting and post-oral-glucose-load levels of methylglyoxal are associated with microvascular, but not macrovascular, disease in individuals with and without (pre)diabetes: The Maastricht Study

Diabetes & metabolism, 2021-02, Vol.47 (1), p.101148-101148, Article 101148

2021

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Time course of the antiproteinuric and antihypertensive effects of direct renin inhibition in type 2 diabetes

Kidney international, 2008-06, Vol.73 (12), p.1419-1425

2008

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Complement activation products C5a and sC5b-9 are associated with low-grade inflammation and endothelial dysfunction, but not with atherosclerosis in a cross-sectional analysis: The CODAM study

International journal of cardiology, 2014-06, Vol.174 (2), p.400-403

2014

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The methylglyoxal-derived AGE tetrahydropyrimidine is increased in plasma of individuals with type 1 diabetes mellitus and in atherosclerotic lesions and is associated with sVCAM-1

Diabetologia, 2013-08, Vol.56 (8), p.1845-1855

2013

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Irbesartan treatment does not influence plasma levels of the dicarbonyls methylglyoxal, glyoxal and 3‐deoxyglucosone in participants with type 2 diabetes and microalbuminuria: An IRMA2 sub‐study

Diabetic medicine, 2021-09, Vol.38 (9), p.e14405-n/a

2021

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Low-grade inflammation can partly explain the association between the metabolic syndrome and either coronary artery disease or severity of peripheral arterial disease: the CODAM study

European journal of clinical investigation, 2009-06, Vol.39 (6), p.437-444

2009

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Methylglyoxal, a Highly Reactive Dicarbonyl Compound, in Diabetes, Its Vascular Complications, and Other Age-Related Diseases

Current therapeutic interventions in the glycation pathway: evidence from clinical studies

Abdominal subcutaneous and visceral adipocyte size, lipolysis and inflammation relate to insulin resistance in male obese humans

Effects of rosuvastatin and atorvastatin on glycaemic control in Type 2 diabetes-the CORALL study

Increased accumulation of the advanced glycation endproduct Ne(carboxymethyl) lysine in the intramyocardial vasculature in patients with epicarditis

Hyperglycaemia-induced impairment of endothelium-dependent vasorelaxation in rat mesenteric arteries is mediated by intracellular methylglyoxal levels in a pathway dependent on oxidative stress

Markers of inflammation are cross-sectionally associated with microvascular complications and cardiovascular disease in type 1 diabetes: the EURODIAB prospective complications study

Long‐term effects of metformin on endothelial function in type 2 diabetes: a randomized controlled trial

Obesity-associated low-grade inflammation in type 2 diabetes mellitus: causes and consequences

Serum levels of autoantibodies against the angiotensin II type I receptor are not associated with serum dicarbonyl or AGE levels in patients with an aldosterone-producing adenoma

Endothelial dysfunction is associated with a greater depressive symptom score in a general elderly population: the Hoorn Study

Associations of Advanced Glycation End-Products With Cognitive Functions in Individuals With and Without Type 2 Diabetes: The Maastricht Study

Plasma matrix metalloproteinases are associated with incident cardiovascular disease and all-cause mortality in patients with type 1 diabetes: a 12-year follow-up study

Plasma proprotein convertase subtilisin kexin type 9 is not altered in subjects with impaired glucose metabolism and type 2 diabetes mellitus, but its relationship with non-HDL cholesterol and apolipoprotein B may be modified by type 2 diabetes mellitus: The CODAM study

The journey of adult psoriasis patients towards biologics: past and present ‐ Results from the BioCAPTURE registry

Protection against methylglyoxal-derived AGEs by regulation of glyoxalase 1 prevents retinal neuroglial and vasodegenerative pathology

Effects of short‐term treatment with metformin on markers of endothelial function and inflammatory activity in type 2 diabetes mellitus: a randomized, placebo‐controlled trial

Alcohol and red wine consumption, but not fruit, vegetables, fish or dairy products, are associated with less endothelial dysfunction and less low-grade inflammation: the Hoorn Study

Dietary intake of advanced glycation end products (AGEs) and changes in body weight in European adults

Fasting and post-oral-glucose-load levels of methylglyoxal are associated with microvascular, but not macrovascular, disease in individuals with and without (pre)diabetes: The Maastricht Study

Time course of the antiproteinuric and antihypertensive effects of direct renin inhibition in type 2 diabetes

Complement activation products C5a and sC5b-9 are associated with low-grade inflammation and endothelial dysfunction, but not with atherosclerosis in a cross-sectional analysis: The CODAM study

The methylglyoxal-derived AGE tetrahydropyrimidine is increased in plasma of individuals with type 1 diabetes mellitus and in atherosclerotic lesions and is associated with sVCAM-1

Irbesartan treatment does not influence plasma levels of the dicarbonyls methylglyoxal, glyoxal and 3‐deoxyglucosone in participants with type 2 diabetes and microalbuminuria: An IRMA2 sub‐study

Low-grade inflammation can partly explain the association between the metabolic syndrome and either coronary artery disease or severity of peripheral arterial disease: the CODAM study

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