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Hemolysis and free hemoglobin revisited: exploring hemoglobin and hemin scavengers as a novel class of therapeutic proteins

Blood, 2013-02, Vol.121 (8), p.1276-1284

2013

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Haptoglobin, hemopexin, and related defense pathways-basic science, clinical perspectives, and drug development

Frontiers in physiology, 2014, Vol.5, p.415

2014

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Activating Transcription Factor 1 Directs Mhem Atheroprotective Macrophages Through Coordinated Iron Handling and Foam Cell Protection

Circulation research, 2012-01, Vol.110 (1), p.20-33

2012

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Wnt5A/CaMKII signaling contributes to the inflammatory response of macrophages and is a target for the antiinflammatory action of activated protein C and interleukin-10

Arteriosclerosis, thrombosis, and vascular biology, 2008-03, Vol.28 (3), p.504-510

2008

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Constitutive Endocytosis of CD163 Mediates Hemoglobin-Heme Uptake and Determines the Noninflammatory and Protective Transcriptional Response of Macrophages to Hemoglobin

Circulation research, 2006-10, Vol.99 (9), p.943-950

2006

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Hemoglobin-based oxygen carriers: from mechanisms of toxicity and clearance to rational drug design

Trends in molecular medicine, 2010-10, Vol.16 (10), p.447-457

2010

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Clinical outcomes in patients with systemic lupus erythematosus treated with belimumab in clinical practice settings: a retrospective analysis of results from the OBSErve study in Switzerland

Swiss medical weekly, 2019-02

2019

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Human Plasma and Recombinant Hemopexins: Heme Binding Revisited

International journal of molecular sciences, 2021-01, Vol.22 (3), p.1199

2021

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CD163 is the macrophage scavenger receptor for native and chemically modified hemoglobins in the absence of haptoglobin

Blood, 2006-01, Vol.107 (1), p.373-380

2006

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Acute Hemolysis and Heme Suppress Anti-CD40 Antibody-Induced Necro-Inflammatory Liver Disease

Frontiers in immunology, 2021-05, Vol.12, p.680855-680855

2021

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MyD88-TLR4-dependent choroid plexus activation precedes perilesional inflammation and secondary brain edema in a mouse model of intracerebral hemorrhage

Journal of neuroinflammation, 2022-12, Vol.19 (1), p.290-290, Article 290

2022

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Determining the Optimal Normalization Factor of Different Target Arteries for ex vivo Vascular Function Experiments: A New Standardized Procedure

Journal of vascular research, 2020-03, Vol.57 (2), p.106-112

2020

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Hemolysis, free hemoglobin toxicity, and scavenger protein therapeutics

Blood, 2022-10, Vol.140 (17), p.1837-1844

2022

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Haptoglobin preserves the CD163 hemoglobin scavenger pathway by shielding hemoglobin from peroxidative modification

Blood, 2009-03, Vol.113 (11), p.2578-2586

2009

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Erythrophagocytes in hemolytic anemia, wound healing, and cancer

Trends in molecular medicine, 2022-11, Vol.28 (11), p.906-915

2022

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Sequestration of extracellular hemoglobin within a haptoglobin complex decreases its hypertensive and oxidative effects in dogs and guinea pigs

The Journal of clinical investigation, 2009-08, Vol.119 (8), p.2271-2280

2009

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Spatial transcriptome data from coronal mouse brain sections after striatal injection of heme and heme-hemopexin

Data in brief, 2022-04, Vol.41, p.107866-107866, Article 107866

2022

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Haptoglobin Therapeutics and Compartmentalization of Cell-Free Hemoglobin Toxicity

Trends in molecular medicine, 2020-07, Vol.26 (7), p.683-697

2020

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Revisiting the putative role of heme as a trigger of inflammation

Pharmacology research & perspectives, 2018-04, Vol.6 (2), p.e00392-n/a

2018

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Expression and secretion of procalcitonin and calcitonin gene-related peptide by adherent monocytes and by macrophage-activated adipocytes

Critical care medicine, 2004-08, Vol.32 (8), p.1715-1721

2004

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Phenotype-specific recombinant haptoglobin polymers co-expressed with C1r-like protein as optimized hemoglobin-binding therapeutics

BMC biotechnology, 2018-03, Vol.18 (1), p.15-15, Article 15

2018

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Agonistic Anti-CD40 Antibody Triggers an Acute Liver Crisis With Systemic Inflammation in Humanized Sickle Cell Disease Mice

Frontiers in immunology, 2021-03, Vol.12, p.627944

2021

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The HeMoVal study protocol: a prospective international multicenter cohort study to validate cerebrospinal fluid hemoglobin as a monitoring biomarker for aneurysmal subarachnoid hemorrhage related secondary brain injury

BMC neurology, 2022-07, Vol.22 (1), p.267-13, Article 267

2022

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CD163-expressing monocytes constitute an endotoxin-sensitive Hb clearance compartment within the vascular system

Journal of leukocyte biology, 2007-07, Vol.82 (1), p.106-110

2007

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Gating the radical hemoglobin to macrophages: the anti-inflammatory role of CD163, a scavenger receptor

Antioxidants & redox signaling, 2007-07, Vol.9 (7), p.991-999

2007

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Hemolysis and free hemoglobin revisited: exploring hemoglobin and hemin scavengers as a novel class of therapeutic proteins

Haptoglobin, hemopexin, and related defense pathways-basic science, clinical perspectives, and drug development

Activating Transcription Factor 1 Directs Mhem Atheroprotective Macrophages Through Coordinated Iron Handling and Foam Cell Protection

Wnt5A/CaMKII signaling contributes to the inflammatory response of macrophages and is a target for the antiinflammatory action of activated protein C and interleukin-10

Constitutive Endocytosis of CD163 Mediates Hemoglobin-Heme Uptake and Determines the Noninflammatory and Protective Transcriptional Response of Macrophages to Hemoglobin

Hemoglobin-based oxygen carriers: from mechanisms of toxicity and clearance to rational drug design

Clinical outcomes in patients with systemic lupus erythematosus treated with belimumab in clinical practice settings: a retrospective analysis of results from the OBSErve study in Switzerland

Human Plasma and Recombinant Hemopexins: Heme Binding Revisited

CD163 is the macrophage scavenger receptor for native and chemically modified hemoglobins in the absence of haptoglobin

Acute Hemolysis and Heme Suppress Anti-CD40 Antibody-Induced Necro-Inflammatory Liver Disease

MyD88-TLR4-dependent choroid plexus activation precedes perilesional inflammation and secondary brain edema in a mouse model of intracerebral hemorrhage

Determining the Optimal Normalization Factor of Different Target Arteries for ex vivo Vascular Function Experiments: A New Standardized Procedure

Hemolysis, free hemoglobin toxicity, and scavenger protein therapeutics

Haptoglobin preserves the CD163 hemoglobin scavenger pathway by shielding hemoglobin from peroxidative modification

Erythrophagocytes in hemolytic anemia, wound healing, and cancer

Sequestration of extracellular hemoglobin within a haptoglobin complex decreases its hypertensive and oxidative effects in dogs and guinea pigs

Spatial transcriptome data from coronal mouse brain sections after striatal injection of heme and heme-hemopexin

Haptoglobin Therapeutics and Compartmentalization of Cell-Free Hemoglobin Toxicity

Revisiting the putative role of heme as a trigger of inflammation

Expression and secretion of procalcitonin and calcitonin gene-related peptide by adherent monocytes and by macrophage-activated adipocytes

Phenotype-specific recombinant haptoglobin polymers co-expressed with C1r-like protein as optimized hemoglobin-binding therapeutics

Agonistic Anti-CD40 Antibody Triggers an Acute Liver Crisis With Systemic Inflammation in Humanized Sickle Cell Disease Mice

The HeMoVal study protocol: a prospective international multicenter cohort study to validate cerebrospinal fluid hemoglobin as a monitoring biomarker for aneurysmal subarachnoid hemorrhage related secondary brain injury

CD163-expressing monocytes constitute an endotoxin-sensitive Hb clearance compartment within the vascular system

Gating the radical hemoglobin to macrophages: the anti-inflammatory role of CD163, a scavenger receptor

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