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Demystifying Functional Parameters for Irreversible Enzyme Inhibitors

Journal of medicinal chemistry, 2024-09, Vol.67 (17), p.14693-14696

2024

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Pitfalls and Considerations in Determining the Potency and Mutant Selectivity of Covalent Epidermal Growth Factor Receptor Inhibitors

Journal of medicinal chemistry, 2024-01, Vol.67 (1), p.2

2024

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Paxillin phosphorylation at Ser273 localizes a GIT1-PIX-PAK complex and regulates adhesion and protrusion dynamics

The Journal of cell biology, 2006-05, Vol.173 (4), p.587-589

2006

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Activation of FOXO1 by Cdk1 in Cycling Cells and Postmitotic Neurons

Science (American Association for the Advancement of Science), 2008-03, Vol.319 (5870), p.1665-1668

2008

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Structural Basis for Inhibition of Mutant EGFR with Lazertinib (YH25448)

ACS medicinal chemistry letters, 2022-12, Vol.13 (12), p.1856-1863

2022

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Neurotropic activity and safety of methylene-cycloalkylacetate (MCA) derivative 3‑(3-allyl-2-methylenecyclohexyl) propanoic acid

ACS chemical neuroscience, 2020-09, Vol.11 (17), p.2577-2589

2020

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Pim-1 regulates cardiomyocyte survival downstream of Akt

Nature medicine, 2007-12, Vol.13 (12), p.1467-1475

2007

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FAK integrates growth-factor and integrin signals to promote cell migration

Nature cell biology, 2000-05, Vol.2 (5), p.249-256

2000

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Linking ATP and allosteric sites to achieve superadditive binding with bivalent EGFR kinase inhibitors

Communications chemistry, 2024-02, Vol.7 (1), p.38-38, Article 38

2024

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Identification of a Proline-rich Akt Substrate as a 14-3-3 Binding Partner

The Journal of biological chemistry, 2003-03, Vol.278 (12), p.10189-10194

2003

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p21-activated Kinase Regulates Endothelial Permeability through Modulation of Contractility

The Journal of biological chemistry, 2004-11, Vol.279 (45), p.46621-46630

2004

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A Selective Small Molecule c-MET Inhibitor, PHA665752, Cooperates with Rapamycin

Clinical cancer research, 2005-03, Vol.11 (6), p.2312-2319

2005

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Evolution of the c‐kit‐Positive Cell Response to Pathological Challenge in the Myocardium

Stem cells (Dayton, Ohio), 2008-05, Vol.26 (5), p.1315-1324

2008

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Synthesis and Pharmacological Characterization of Visabron, a Backbone Cyclic Peptide Dual Antagonist of α4β1 (VLA-4)/α9β1 Integrin for Therapy of Multiple Sclerosis

JACS Au, 2021-12, Vol.1 (12), p.2361-2376

2021

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Akt Promotes Increased Cardiomyocyte Cycling and Expansion of the Cardiac Progenitor Cell Population

Circulation research, 2006-08, Vol.99 (4), p.381-388

2006

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Nuclear Targeting of Akt Enhances Kinase Activity and Survival of Cardiomyocytes

Circulation research, 2004-04, Vol.94 (7), p.884-891

2004

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Cortactin tyrosine phosphorylation requires Rac1 activity and association with the cortical actin cytoskeleton

Molecular biology of the cell, 2003-08, Vol.14 (8), p.3216-3229

2003

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Integrin-induced Epidermal Growth Factor (EGF) Receptor Activation Requires c-Src and p130Cas and Leads to Phosphorylation of Specific EGF Receptor Tyrosines

The Journal of biological chemistry, 2002-03, Vol.277 (11), p.9405-9414

2002

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Localized Suppression of RhoA Activity by Tyr31/118-Phosphorylated Paxillin in Cell Adhesion and Migration

The Journal of cell biology, 2002-11, Vol.159 (4), p.673-683

2002

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Modulation of the c-Met/Hepatocyte Growth Factor Pathway in Small Cell Lung Cancer

Clinical cancer research, 2002-02, Vol.8 (2), p.620-627

2002

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Pim-1 kinase antagonizes aspects of myocardial hypertrophy and compensation to pathological pressure overload

Proceedings of the National Academy of Sciences - PNAS, 2008-09, Vol.105 (37), p.13889-13894

2008

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Phosphorylation of phosphoprotein enriched in astrocytes (PEA-15) regulates extracellular signal-regulated kinase-dependent transcription and cell proliferation

Molecular biology of the cell, 2005-08, Vol.16 (8), p.3552-3561

2005

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Phosphorylation of the Pro-X-Thr-Pro site in phosphatase inhibitor-2 by cyclin-dependent protein kinase during M-phase of the cell cycle

Cellular signalling, 2006-08, Vol.18 (8), p.1318-1326

2006

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Vectorial spin polarization detection in multichannel spin-resolved photoemission spectroscopy using an Ir(001) imaging spin filter

Physical review. B, 2017-03, Vol.95 (10), p.104423, Article 104423

2017

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Myocardial Induction of Nucleostemin in Response to Postnatal Growth and Pathological Challenge

Circulation research, 2008-07, Vol.103 (1), p.89-97

2008

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Demystifying Functional Parameters for Irreversible Enzyme Inhibitors

Pitfalls and Considerations in Determining the Potency and Mutant Selectivity of Covalent Epidermal Growth Factor Receptor Inhibitors

Paxillin phosphorylation at Ser273 localizes a GIT1-PIX-PAK complex and regulates adhesion and protrusion dynamics

Activation of FOXO1 by Cdk1 in Cycling Cells and Postmitotic Neurons

Structural Basis for Inhibition of Mutant EGFR with Lazertinib (YH25448)

Neurotropic activity and safety of methylene-cycloalkylacetate (MCA) derivative 3‑(3-allyl-2-methylenecyclohexyl) propanoic acid

Pim-1 regulates cardiomyocyte survival downstream of Akt

FAK integrates growth-factor and integrin signals to promote cell migration

Linking ATP and allosteric sites to achieve superadditive binding with bivalent EGFR kinase inhibitors

Identification of a Proline-rich Akt Substrate as a 14-3-3 Binding Partner

p21-activated Kinase Regulates Endothelial Permeability through Modulation of Contractility

A Selective Small Molecule c-MET Inhibitor, PHA665752, Cooperates with Rapamycin

Evolution of the c‐kit‐Positive Cell Response to Pathological Challenge in the Myocardium

Synthesis and Pharmacological Characterization of Visabron, a Backbone Cyclic Peptide Dual Antagonist of α4β1 (VLA-4)/α9β1 Integrin for Therapy of Multiple Sclerosis

Akt Promotes Increased Cardiomyocyte Cycling and Expansion of the Cardiac Progenitor Cell Population

Nuclear Targeting of Akt Enhances Kinase Activity and Survival of Cardiomyocytes

Cortactin tyrosine phosphorylation requires Rac1 activity and association with the cortical actin cytoskeleton

Integrin-induced Epidermal Growth Factor (EGF) Receptor Activation Requires c-Src and p130Cas and Leads to Phosphorylation of Specific EGF Receptor Tyrosines

Localized Suppression of RhoA Activity by Tyr31/118-Phosphorylated Paxillin in Cell Adhesion and Migration

Modulation of the c-Met/Hepatocyte Growth Factor Pathway in Small Cell Lung Cancer

Pim-1 kinase antagonizes aspects of myocardial hypertrophy and compensation to pathological pressure overload

Phosphorylation of phosphoprotein enriched in astrocytes (PEA-15) regulates extracellular signal-regulated kinase-dependent transcription and cell proliferation

Phosphorylation of the Pro-X-Thr-Pro site in phosphatase inhibitor-2 by cyclin-dependent protein kinase during M-phase of the cell cycle

Vectorial spin polarization detection in multichannel spin-resolved photoemission spectroscopy using an Ir(001) imaging spin filter

Myocardial Induction of Nucleostemin in Response to Postnatal Growth and Pathological Challenge

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