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Small molecule PIKfyve inhibitors as cancer therapeutics: Translational promises and limitations

Toxicology and applied pharmacology, 2019-11, Vol.383, p.114771, Article 114771

2019

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Plentiful PtdIns5P from scanty PtdIns(3,5)P2 or from ample PtdIns? PIKfyve‐dependent models: Evidence and speculation (response to: DOI 10.1002/bies.201300012)

BioEssays, 2015-03, Vol.37 (3), p.267-277

2015

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Adaptor proteins mediate CXCR4 and PI4KA crosstalk in prostate cancer cells and the significance of PI4KA in bone tumor growth

Scientific reports, 2023-11, Vol.13 (1), p.20634-20634, Article 20634

2023

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Apilimod, a candidate anticancer therapeutic, arrests not only PtdIns(3,5)P2 but also PtdIns5P synthesis by PIKfyve and induces bafilomycin A1-reversible aberrant endomembrane dilation

PloS one, 2018, Vol.13 (9), p.e0204532-e0204532

2018

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Class III PI 3-kinase is the main source of PtdIns3P substrate and membrane recruitment signal for PIKfyve constitutive function in podocyte endomembrane homeostasis

Biochimica et biophysica acta, 2015-05, Vol.1853 (5), p.1240-1250

2015

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YM201636, an inhibitor of retroviral budding and PIKfyve-catalyzed PtdIns(3,5)P2 synthesis, halts glucose entry by insulin in adipocytes

Biochemical and biophysical research communications, 2009-05, Vol.382 (3), p.566-570

2009

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ArPIKfyve Homomeric and Heteromeric Interactions Scaffold PIKfyve and Sac3 in a Complex to Promote PIKfyve Activity and Functionality

Journal of molecular biology, 2008-12, Vol.384 (4), p.766-779

2008

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Mammalian Cell Morphology and Endocytic Membrane Homeostasis Require Enzymatically Active Phosphoinositide 5-Kinase PIKfyve

The Journal of biological chemistry, 2001-07, Vol.276 (28), p.26141-26147

2001

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The PIKfyve–ArPIKfyve–Sac3 triad in human breast cancer: Functional link between elevated Sac3 phosphatase and enhanced proliferation of triple negative cell lines

Biochemical and biophysical research communications, 2013-10, Vol.440 (2), p.342-347

2013

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cdc-like/dual-specificity tyrosine phosphorylation-regulated kinases inhibitor leucettine L41 induces mTOR-dependent autophagy: implication for Alzheimer's disease

Molecular pharmacology, 2014-03, Vol.85 (3), p.441-450

2014

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Acquisition of Unprecedented Phosphatidylinositol 3,5-Bisphosphate Rise in Hyperosmotically Stressed 3T3-L1 Adipocytes, Mediated by ArPIKfyve-PIKfyve Pathway

The Journal of biological chemistry, 2005-03, Vol.280 (9), p.7883-7889

2005

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Role for a Novel Signaling Intermediate, Phosphatidylinositol 5-Phosphate, in Insulin-Regulated F-Actin Stress Fiber Breakdown and GLUT4 Translocation

Endocrinology (Philadelphia), 2004-11, Vol.145 (11), p.4853-4865

2004

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ArPIKfyve–PIKfyve interaction and role in insulin-regulated GLUT4 translocation and glucose transport in 3T3-L1 adipocytes

Experimental cell research, 2007-07, Vol.313 (11), p.2404-2416

2007

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Abstract 2293: Role of phosphatidylinositol 4-kinase IIIα in chemokine signaling

Cancer research (Chicago, Ill.), 2021-07, Vol.81 (13_Supplement), p.2293-2293

2021

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Kinesin Adapter JLP Links PIKfyve to Microtubule-based Endosome-to-Trans-Golgi Network Traffic of Furin

The Journal of biological chemistry, 2009-02, Vol.284 (6), p.3750-3761

2009

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Functional dissociation between PIKfyve-synthesized PtdIns5P and PtdIns(3,5)P2 by means of the PIKfyve inhibitor YM201636

American Journal of Physiology: Cell Physiology, 2012-08, Vol.303 (4), p.C436-C446

2012

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1510-PUB: Genetic Variants in PIKFYVE, SAC3/FIG4, and ARPIKFYVE/VAC14 as Risk Factors for Development of Type 2 Diabetes in Obesity

Diabetes (New York, N.Y.), 2022-06, Vol.71 (Supplement_1)

2022

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Plentiful PtdIns5P from scanty PtdIns(3,5)P 2 or from ample PtdIns? PIKfyve‐dependent models: Evidence and speculation (response to: DOI 10.1002/bies.201300012)

BioEssays, 2015-03, Vol.37 (3), p.267-277

2015

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Functional Dissection of Lipid and Protein Kinase Signals of PIKfyve Reveals the Role of PtdIns 3,5-P2 Production for Endomembrane Integrity

The Journal of biological chemistry, 2002-03, Vol.277 (11), p.9206-9211

2002

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A Mammalian Ortholog of Saccharomyces cerevisiae Vac14 That Associates with and Up-Regulates PIKfyve Phosphoinositide 5-Kinase Activity

Molecular and Cellular Biology, 2004-12, Vol.24 (23), p.10437-10447

2004

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PIKfyve-ArPIKfyve-Sac3 Core Complex

The Journal of biological chemistry, 2009-12, Vol.284 (51), p.35794-35806

2009

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Active PIKfyve Associates with and Promotes the Membrane Attachment of the Late Endosome-to-trans-Golgi Network Transport Factor Rab9 Effector p40

The Journal of biological chemistry, 2003-12, Vol.278 (51), p.50863-50871

2003

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The Phosphoinositide Kinase PIKfyve Is Vital in Early Embryonic Development

The Journal of biological chemistry, 2011-04, Vol.286 (15), p.13404-13413

2011

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Severe Consequences of SAC3/FIG4 Phosphatase Deficiency to Phosphoinositides in Patients with Charcot-Marie-Tooth Disease Type-4J

Molecular neurobiology, 2019-12, Vol.56 (12), p.8656-8667

2019

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Sac3 Is an Insulin-regulated Phosphatidylinositol 3,5-Bisphosphate Phosphatase

The Journal of biological chemistry, 2009-09, Vol.284 (36), p.23961-23971

2009

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Small molecule PIKfyve inhibitors as cancer therapeutics: Translational promises and limitations

Plentiful PtdIns5P from scanty PtdIns(3,5)P2 or from ample PtdIns? PIKfyve‐dependent models: Evidence and speculation (response to: DOI 10.1002/bies.201300012)

Adaptor proteins mediate CXCR4 and PI4KA crosstalk in prostate cancer cells and the significance of PI4KA in bone tumor growth

Apilimod, a candidate anticancer therapeutic, arrests not only PtdIns(3,5)P2 but also PtdIns5P synthesis by PIKfyve and induces bafilomycin A1-reversible aberrant endomembrane dilation

Class III PI 3-kinase is the main source of PtdIns3P substrate and membrane recruitment signal for PIKfyve constitutive function in podocyte endomembrane homeostasis

YM201636, an inhibitor of retroviral budding and PIKfyve-catalyzed PtdIns(3,5)P2 synthesis, halts glucose entry by insulin in adipocytes

ArPIKfyve Homomeric and Heteromeric Interactions Scaffold PIKfyve and Sac3 in a Complex to Promote PIKfyve Activity and Functionality

Mammalian Cell Morphology and Endocytic Membrane Homeostasis Require Enzymatically Active Phosphoinositide 5-Kinase PIKfyve

The PIKfyve–ArPIKfyve–Sac3 triad in human breast cancer: Functional link between elevated Sac3 phosphatase and enhanced proliferation of triple negative cell lines

cdc-like/dual-specificity tyrosine phosphorylation-regulated kinases inhibitor leucettine L41 induces mTOR-dependent autophagy: implication for Alzheimer's disease

Acquisition of Unprecedented Phosphatidylinositol 3,5-Bisphosphate Rise in Hyperosmotically Stressed 3T3-L1 Adipocytes, Mediated by ArPIKfyve-PIKfyve Pathway

Role for a Novel Signaling Intermediate, Phosphatidylinositol 5-Phosphate, in Insulin-Regulated F-Actin Stress Fiber Breakdown and GLUT4 Translocation

ArPIKfyve–PIKfyve interaction and role in insulin-regulated GLUT4 translocation and glucose transport in 3T3-L1 adipocytes

Abstract 2293: Role of phosphatidylinositol 4-kinase IIIα in chemokine signaling

Kinesin Adapter JLP Links PIKfyve to Microtubule-based Endosome-to-Trans-Golgi Network Traffic of Furin

Functional dissociation between PIKfyve-synthesized PtdIns5P and PtdIns(3,5)P2 by means of the PIKfyve inhibitor YM201636

1510-PUB: Genetic Variants in PIKFYVE, SAC3/FIG4, and ARPIKFYVE/VAC14 as Risk Factors for Development of Type 2 Diabetes in Obesity

Plentiful PtdIns5P from scanty PtdIns(3,5)P 2 or from ample PtdIns? PIKfyve‐dependent models: Evidence and speculation (response to: DOI 10.1002/bies.201300012)

Functional Dissection of Lipid and Protein Kinase Signals of PIKfyve Reveals the Role of PtdIns 3,5-P2 Production for Endomembrane Integrity

A Mammalian Ortholog of Saccharomyces cerevisiae Vac14 That Associates with and Up-Regulates PIKfyve Phosphoinositide 5-Kinase Activity

PIKfyve-ArPIKfyve-Sac3 Core Complex

Active PIKfyve Associates with and Promotes the Membrane Attachment of the Late Endosome-to-trans-Golgi Network Transport Factor Rab9 Effector p40

The Phosphoinositide Kinase PIKfyve Is Vital in Early Embryonic Development

Severe Consequences of SAC3/FIG4 Phosphatase Deficiency to Phosphoinositides in Patients with Charcot-Marie-Tooth Disease Type-4J

Sac3 Is an Insulin-regulated Phosphatidylinositol 3,5-Bisphosphate Phosphatase

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