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Neonicotinoid Insecticides: Molecular Targets, Resistance, and Toxicity

Annual review of pharmacology and toxicology, 2020-01, Vol.60 (1), p.241-255

2020

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Modes of Action, Resistance and Toxicity of Insecticides Targeting Nicotinic Acetylcholine Receptors

Current medicinal chemistry, 2017-08, Vol.24 (27), p.2925

2017

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Mechanisms of Action, Resistance and Toxicity of Insecticides Targeting GABA Receptors

Current medicinal chemistry, 2017-08, Vol.24 (27), p.2935

2017

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Nicotinic acetylcholine receptor signalling: roles in Alzheimer's disease and amyloid neuroprotection

Pharmacological reviews, 2009-03, Vol.61 (1), p.39-61

2009

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The cys-loop ligand-gated ion channel gene superfamily of the red flour beetle, Tribolium castaneum

BMC genomics, 2007-09, Vol.8 (1), p.327-327

2007

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Aedes aegypti CCEae3A carboxylase expression confers carbamate, organophosphate and limited pyrethroid resistance in a model transgenic mosquito

PLoS neglected tropical diseases, 2024-02, Vol.18 (2), p.e0011595

2024

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Fast, automated measurement of nematode swimming (thrashing) without morphometry

BMC neuroscience, 2009-07, Vol.10 (1), p.84-84, Article 84

2009

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Functional impact of subunit composition and compensation on Drosophila melanogaster nicotinic receptors-targets of neonicotinoids

PLoS genetics, 2023-02, Vol.19 (2), p.e1010522-e1010522

2023

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Diverse Actions and Target-Site Selectivity of Neonicotinoids: Structural Insights

Molecular pharmacology, 2009-07, Vol.76 (1), p.1-10

2009

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Automated phenotyping of mosquito larvae enables high-throughput screening for novel larvicides and offers potential for smartphone-based detection of larval insecticide resistance

PLoS neglected tropical diseases, 2021-06, Vol.15 (6), p.e0008639

2021

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Loops D, E and G in the Drosophila Dα1 subunit contribute to high neonicotinoid sensitivity of Dα1‐chicken β2 nicotinic acetylcholine receptor

British journal of pharmacology, 2018-06, Vol.175 (11), p.1999-2012

2018

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Anthelmintic drug discovery: target identification, screening methods and the role of open science

Beilstein journal of organic chemistry, 2020-06, Vol.16 (1), p.1203-1224

2020

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An automated high-throughput system for phenotypic screening of chemical libraries on C. elegans and parasitic nematodes

International journal for parasitology -- drugs and drug resistance, 2018-04, Vol.8 (1), p.8-21

2018

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Automated, high-throughput, motility analysis in Caenorhabditis elegans and parasitic nematodes: Applications in the search for new anthelmintics

International journal for parasitology -- drugs and drug resistance, 2014-12, Vol.4 (3), p.226-232

2014

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Glutamate-gated chloride channels of Haemonchus contortus restore drug sensitivity to ivermectin resistant Caenorhabditis elegans

PloS one, 2011-07, Vol.6 (7), p.e22390-e22390

2011

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Studies on an acetylcholine binding protein identify a basic residue in loop G on the β1 strand as a new structural determinant of neonicotinoid actions

Molecular pharmacology, 2014-12, Vol.86 (6), p.736-746

2014

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Actions of Camptothecin Derivatives on Larvae and Adults of the Arboviral Vector Aedes aegypti

Molecules (Basel, Switzerland), 2021-10, Vol.26 (20), p.6226

2021

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The nicotinic acetylcholine receptor gene family of the honey bee, Apis mellifera

Genome Research, 2006-11, Vol.16 (11), p.1422-1430

2006

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Okaramine insecticidal alkaloids show similar activity on both exon 3c and exon 3b variants of glutamate-gated chloride channels of the larval silkworm, Bombyx mori

Neurotoxicology (Park Forest South), 2017-05, Vol.60, p.240-244

2017

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Probing new components (loop G and the α–α interface) of neonicotinoid binding sites on nicotinic acetylcholine receptors

Pesticide biochemistry and physiology, 2015-06, Vol.121, p.47-52

2015

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C. elegans expressing D76N β2-microglobulin: a model for in vivo screening of drug candidates targeting amyloidosis

Scientific reports, 2019-12, Vol.9 (1), p.1-10, Article 19960

2019

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Invertebrate neurones, genomes, phenotypic and target-based screening; their contributions to the search for new chemical leads and new molecular targets for the control of pests, parasites and disease vectors

Pesticide biochemistry and physiology, 2022-10, Vol.187, p.105175-105175, Article 105175

Sattelle, David B.

2022

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Unravelling nicotinic receptor and ligand features underlying neonicotinoid knockdown actions on the malaria vector mosquito Anopheles gambiae

Open biology, 2024-07, Vol.14 (7), p.240057

2024

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A drug repurposing screen for whipworms informed by comparative genomics

PLoS neglected tropical diseases, 2023-09, Vol.17 (9), p.e0011205-e0011205

2023

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2,4-Diaminothieno[3,2-d]pyrimidines, a new class of anthelmintic with activity against adult and egg stages of whipworm

PLoS neglected tropical diseases, 2018-07, Vol.12 (7), p.e0006487

2018

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Neonicotinoid Insecticides: Molecular Targets, Resistance, and Toxicity

Modes of Action, Resistance and Toxicity of Insecticides Targeting Nicotinic Acetylcholine Receptors

Mechanisms of Action, Resistance and Toxicity of Insecticides Targeting GABA Receptors

Nicotinic acetylcholine receptor signalling: roles in Alzheimer's disease and amyloid neuroprotection

The cys-loop ligand-gated ion channel gene superfamily of the red flour beetle, Tribolium castaneum

Aedes aegypti CCEae3A carboxylase expression confers carbamate, organophosphate and limited pyrethroid resistance in a model transgenic mosquito

Fast, automated measurement of nematode swimming (thrashing) without morphometry

Functional impact of subunit composition and compensation on Drosophila melanogaster nicotinic receptors-targets of neonicotinoids

Diverse Actions and Target-Site Selectivity of Neonicotinoids: Structural Insights

Automated phenotyping of mosquito larvae enables high-throughput screening for novel larvicides and offers potential for smartphone-based detection of larval insecticide resistance

Loops D, E and G in the Drosophila Dα1 subunit contribute to high neonicotinoid sensitivity of Dα1‐chicken β2 nicotinic acetylcholine receptor

Anthelmintic drug discovery: target identification, screening methods and the role of open science

An automated high-throughput system for phenotypic screening of chemical libraries on C. elegans and parasitic nematodes

Automated, high-throughput, motility analysis in Caenorhabditis elegans and parasitic nematodes: Applications in the search for new anthelmintics

Glutamate-gated chloride channels of Haemonchus contortus restore drug sensitivity to ivermectin resistant Caenorhabditis elegans

Studies on an acetylcholine binding protein identify a basic residue in loop G on the β1 strand as a new structural determinant of neonicotinoid actions

Actions of Camptothecin Derivatives on Larvae and Adults of the Arboviral Vector Aedes aegypti

The nicotinic acetylcholine receptor gene family of the honey bee, Apis mellifera

Okaramine insecticidal alkaloids show similar activity on both exon 3c and exon 3b variants of glutamate-gated chloride channels of the larval silkworm, Bombyx mori

Probing new components (loop G and the α–α interface) of neonicotinoid binding sites on nicotinic acetylcholine receptors

C. elegans expressing D76N β2-microglobulin: a model for in vivo screening of drug candidates targeting amyloidosis

Invertebrate neurones, genomes, phenotypic and target-based screening; their contributions to the search for new chemical leads and new molecular targets for the control of pests, parasites and disease vectors

Unravelling nicotinic receptor and ligand features underlying neonicotinoid knockdown actions on the malaria vector mosquito Anopheles gambiae

A drug repurposing screen for whipworms informed by comparative genomics

2,4-Diaminothieno[3,2-d]pyrimidines, a new class of anthelmintic with activity against adult and egg stages of whipworm

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