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A cell-free expression and purification process for rapid production of protein biologics

Biotechnology journal, 2016-02, Vol.11 (2), p.238-248

2016

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Actin exposure upon tissue injury is a targetable wound site-specific protein marker

Biochemistry and biophysics reports, 2016-09, Vol.7, p.56-62

2016

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2'-O-(2-Methoxy)ethyl-modified anti-intercellular adhesion molecule 1 (ICAM-1) oligonucleotides selectively increase the ICAM-1 mRNA level and inhibit formation of the ICAM-1 translation initiation complex in human umbilical vein endothelial cells

The Journal of biological chemistry, 1997-05, Vol.272 (18), p.11994-12000

1997

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Nuclease Resistance and Antisense Activity of Modified Oligonucleotides Targeted to Ha-ras

The Journal of biological chemistry, 1996-06, Vol.271 (24), p.14533

1996

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Measurement of Macromolecular Binding Using Electrospray Mass Spectrometry. Determination of Dissociation Constants for Oligonucleotide: Serum Albumin Complexes

Journal of the American Chemical Society, 1995-11, Vol.117 (43), p.10765-10766

1995

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Sequence-Specific Antitumor Activity of a Phosphorothioate Oligodeoxyribonucleotide Targeted to Human C-Raf Kinase Supports an Antisense Mechanism of Action in vivo

Proceedings of the National Academy of Sciences - PNAS, 1996-12, Vol.93 (26), p.15481-15484

1996

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Oligonucleotide-europium complex conjugate designed to cleave the 5' cap structure of the ICAM-1 transcript potentiates antisense activity in cells

Nucleic acids research, 1999-03, Vol.27 (6), p.1547

1999

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Pharmacokinetic properties of 2'-O-(2-methoxyethyl)-modified oligonucleotide analogs in rats

The Journal of pharmacology and experimental therapeutics, 2001-03, Vol.296 (3), p.890

2001

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Pharmacokinetics of a tumor necrosis factor-alpha phosphorothioate 2'-O-(2-methoxyethyl) modified antisense oligonucleotide: comparison across species

Drug metabolism and disposition, 2003-11, Vol.31 (11), p.1419

2003

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Antisense oligodeoxynucleotides: synthesis, biophysical and biological evaluation of oligodeoxynucleotides containing modified pyrimidines

Nucleic acids research, 1993-07, Vol.21 (14), p.3197-3203

1993

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Characterization of a potent and specific class of antisense oligonucleotide inhibitor of human protein kinase C-alpha expression

The Journal of biological chemistry, 1999-01, Vol.274 (3), p.1715-1722

1999

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Pharmacokinetic properties of several novel oligonucleotide analogs in mice

The Journal of pharmacology and experimental therapeutics, 1996-05, Vol.277 (2), p.923

1996

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Antisense oligonucleotide inhibition of hepatitis C virus gene expression in transformed hepatocytes

Journal of Virology, 1996-08, Vol.70 (8), p.5203-5212

1996

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Absolute bioavailability of 2'-O-(2-methoxyethyl)-modified antisense oligonucleotides following intraduodenal instillation in rats

The Journal of pharmacology and experimental therapeutics, 2001-03, Vol.296 (3), p.898

2001

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Specific binding of lac repressor to linear versus circular polyoperator molecules

Biochemistry (Easton), 1990-09, Vol.29 (38), p.9023-9028

1990

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Multiplexed Screening of Neutral Mass-Tagged RNA Targets against Ligand Libraries with Electrospray Ionization FTICR MS: A Paradigm for High-Throughput Affinity Screening

Analytical chemistry (Washington), 1999-08, Vol.71 (16), p.3436-3440

1999

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Targeted Site-Specific Gas-Phase Cleavage of Oligoribonucleotides. Application in Mass Spectrometry-Based Identification of Ligand Binding Sites

Journal of the American Chemical Society, 1999-01, Vol.121 (2), p.474-475

1999

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Oligodeoxynucleotides containing 2'-O-modified adenosine: Synthesis and effects on stability of DNA:RNA duplexes

Biochemistry (Easton), 1993-08, Vol.32 (30), p.7832-7838

1993

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Absorption of antisense oligonucleotides in rat intestine: effect of chemistry and length

Antisense & nucleic acid drug development, 2000-02, Vol.10 (1), p.35-44

2000

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Synthesis, hybridization, and nuclease resistance properties of 2′-O-aminooxyethyl ( 2′-O-AOE) modified oligonucleotides

Tetrahedron letters, 1999-01, Vol.40 (4), p.661-664

1999

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Antisense oligonucleotides targeting human protein kinase C-alpha inhibit phorbol ester-induced reduction of bradykinin-evoked calcium mobilization in A549 cells

Molecular pharmacology, 1997-02, Vol.51 (2), p.209-216

1997

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A Perfectly Symmetric lac Operator Binds the lac Repressor Very Tightly

Proceedings of the National Academy of Sciences - PNAS, 1983-11, Vol.80 (22), p.6785-6789

1983

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Oligonucleotide charge states in negative ionization electrospray-mass spectrometry are a function of solution ammonium ion concentration

Journal of the American Society for Mass Spectrometry, 1997-02, Vol.8 (2), p.155-160

1997

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Antisense Oligonucleotides Targeting Human Protein Kinase C-Î± Inhibit Phorbol Ester-Induced Reduction of Bradykinin-Evoked Calcium Mobilization in A549 Cells

Molecular pharmacology, 1997-02, Vol.51 (2), p.209

1997

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Pharmacokinetics in mice of a [3H]-labeled phosphorothioate oligonucleotide formulated in the presence and absence of a cationic lipid

Journal of controlled release, 1996-08, Vol.41 (1-2), p.121-130

1996

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A cell-free expression and purification process for rapid production of protein biologics

Actin exposure upon tissue injury is a targetable wound site-specific protein marker

2'-O-(2-Methoxy)ethyl-modified anti-intercellular adhesion molecule 1 (ICAM-1) oligonucleotides selectively increase the ICAM-1 mRNA level and inhibit formation of the ICAM-1 translation initiation complex in human umbilical vein endothelial cells

Nuclease Resistance and Antisense Activity of Modified Oligonucleotides Targeted to Ha-ras

Measurement of Macromolecular Binding Using Electrospray Mass Spectrometry. Determination of Dissociation Constants for Oligonucleotide: Serum Albumin Complexes

Sequence-Specific Antitumor Activity of a Phosphorothioate Oligodeoxyribonucleotide Targeted to Human C-Raf Kinase Supports an Antisense Mechanism of Action in vivo

Oligonucleotide-europium complex conjugate designed to cleave the 5' cap structure of the ICAM-1 transcript potentiates antisense activity in cells

Pharmacokinetic properties of 2'-O-(2-methoxyethyl)-modified oligonucleotide analogs in rats

Pharmacokinetics of a tumor necrosis factor-alpha phosphorothioate 2'-O-(2-methoxyethyl) modified antisense oligonucleotide: comparison across species

Antisense oligodeoxynucleotides: synthesis, biophysical and biological evaluation of oligodeoxynucleotides containing modified pyrimidines

Characterization of a potent and specific class of antisense oligonucleotide inhibitor of human protein kinase C-alpha expression

Pharmacokinetic properties of several novel oligonucleotide analogs in mice

Antisense oligonucleotide inhibition of hepatitis C virus gene expression in transformed hepatocytes

Absolute bioavailability of 2'-O-(2-methoxyethyl)-modified antisense oligonucleotides following intraduodenal instillation in rats

Specific binding of lac repressor to linear versus circular polyoperator molecules

Multiplexed Screening of Neutral Mass-Tagged RNA Targets against Ligand Libraries with Electrospray Ionization FTICR MS: A Paradigm for High-Throughput Affinity Screening

Targeted Site-Specific Gas-Phase Cleavage of Oligoribonucleotides. Application in Mass Spectrometry-Based Identification of Ligand Binding Sites

Oligodeoxynucleotides containing 2'-O-modified adenosine: Synthesis and effects on stability of DNA:RNA duplexes

Absorption of antisense oligonucleotides in rat intestine: effect of chemistry and length

Synthesis, hybridization, and nuclease resistance properties of 2′-O-aminooxyethyl ( 2′-O-AOE) modified oligonucleotides

Antisense oligonucleotides targeting human protein kinase C-alpha inhibit phorbol ester-induced reduction of bradykinin-evoked calcium mobilization in A549 cells

A Perfectly Symmetric lac Operator Binds the lac Repressor Very Tightly

Oligonucleotide charge states in negative ionization electrospray-mass spectrometry are a function of solution ammonium ion concentration

Antisense Oligonucleotides Targeting Human Protein Kinase C-Î± Inhibit Phorbol Ester-Induced Reduction of Bradykinin-Evoked Calcium Mobilization in A549 Cells

Pharmacokinetics in mice of a [3H]-labeled phosphorothioate oligonucleotide formulated in the presence and absence of a cationic lipid

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