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A cell-free expression and purification process for rapid production of protein biologics

Biotechnology journal, 2016-02, Vol.11 (2), p.238-248

2016

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Pharmacokinetic properties of several novel oligonucleotide analogs in mice

The Journal of pharmacology and experimental therapeutics, 1996-05, Vol.277 (2), p.923

1996

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2'-O-(2-Methoxy)ethyl-modified anti-intercellular adhesion molecule 1 (ICAM-1) oligonucleotides selectively increase the ICAM-1 mRNA level and inhibit formation of the ICAM-1 translation initiation complex in human umbilical vein endothelial cells

The Journal of biological chemistry, 1997-05, Vol.272 (18), p.11994-12000

1997

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Antisense oligonucleotide inhibition of hepatitis C virus gene expression in transformed hepatocytes

Journal of Virology, 1996-08, Vol.70 (8), p.5203-5212

1996

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Oligonucleotide-europium complex conjugate designed to cleave the 5' cap structure of the ICAM-1 transcript potentiates antisense activity in cells

Nucleic acids research, 1999-03, Vol.27 (6), p.1547

1999

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Pharmacokinetic properties of 2'-O-(2-methoxyethyl)-modified oligonucleotide analogs in rats

The Journal of pharmacology and experimental therapeutics, 2001-03, Vol.296 (3), p.890

2001

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Actin exposure upon tissue injury is a targetable wound site-specific protein marker

Biochemistry and biophysics reports, 2016-09, Vol.7, p.56-62

2016

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Pharmacokinetics of a tumor necrosis factor-alpha phosphorothioate 2'-O-(2-methoxyethyl) modified antisense oligonucleotide: comparison across species

Drug metabolism and disposition, 2003-11, Vol.31 (11), p.1419

2003

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A Perfectly Symmetric lac Operator Binds the lac Repressor Very Tightly

Proceedings of the National Academy of Sciences - PNAS, 1983-11, Vol.80 (22), p.6785-6789

1983

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Characterization of a potent and specific class of antisense oligonucleotide inhibitor of human protein kinase C-alpha expression

The Journal of biological chemistry, 1999-01, Vol.274 (3), p.1715-1722

1999

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Hydration of single-stranded phosphodiester and phosphorothioate oligodeoxyribonucleotides

Nucleic acids research, 1996-08, Vol.24 (16), p.3261

1996

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Nuclease Resistance and Antisense Activity of Modified Oligonucleotides Targeted to Ha-ras

The Journal of biological chemistry, 1996-06, Vol.271 (24), p.14533

1996

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Measurement of Macromolecular Binding Using Electrospray Mass Spectrometry. Determination of Dissociation Constants for Oligonucleotide: Serum Albumin Complexes

Journal of the American Chemical Society, 1995-11, Vol.117 (43), p.10765-10766

1995

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Sequence-Specific Antitumor Activity of a Phosphorothioate Oligodeoxyribonucleotide Targeted to Human C-Raf Kinase Supports an Antisense Mechanism of Action in vivo

Proceedings of the National Academy of Sciences - PNAS, 1996-12, Vol.93 (26), p.15481-15484

1996

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Influence of Diastereomeric Ratios of Deoxyribonucleoside Phosphoramidites on the Synthesis of Phosphorothioate Oligonucleotides

Nucleosides, nucleotides & nucleic acids, 2000-03, Vol.19 (3), p.533-543

2000

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Specific binding of lac repressor to linear versus circular polyoperator molecules

Biochemistry (Easton), 1990-09, Vol.29 (38), p.9023-9028

1990

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Multiplexed Screening of Neutral Mass-Tagged RNA Targets against Ligand Libraries with Electrospray Ionization FTICR MS: A Paradigm for High-Throughput Affinity Screening

Analytical chemistry (Washington), 1999-08, Vol.71 (16), p.3436-3440

1999

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Absolute bioavailability of 2'-O-(2-methoxyethyl)-modified antisense oligonucleotides following intraduodenal instillation in rats

The Journal of pharmacology and experimental therapeutics, 2001-03, Vol.296 (3), p.898

2001

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Targeted Site-Specific Gas-Phase Cleavage of Oligoribonucleotides. Application in Mass Spectrometry-Based Identification of Ligand Binding Sites

Journal of the American Chemical Society, 1999-01, Vol.121 (2), p.474-475

1999

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2‘-O-Aminopropyl Ribonucleotides: A Zwitterionic Modification That Enhances the Exonuclease Resistance and Biological Activity of Antisense Oligonucleotides

Journal of medicinal chemistry, 1996-12, Vol.39 (26), p.5100-5109

1996

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Oligodeoxynucleotides containing 2'-O-modified adenosine: Synthesis and effects on stability of DNA:RNA duplexes

Biochemistry (Easton), 1993-08, Vol.32 (30), p.7832-7838

1993

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Symmetric lac operator derivatives: effects of half-operator sequence and spacing on repressor affinity

Gene, 1990-04, Vol.89 (1), p.1-6

1990

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Base substitution mutants of the lac operator: in vivo and in vitro affinities for lac repressor

Gene, 1986, Vol.50 (1), p.123-132

1986

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Disposition of the 14C-labeled phosphorothioate oligonucleotide ISIS 2105 after intravenous administration to rats

The Journal of pharmacology and experimental therapeutics, 1993-12, Vol.267 (3), p.1181

1993

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Synthesis, hybridization, and nuclease resistance properties of 2′-O-aminooxyethyl ( 2′-O-AOE) modified oligonucleotides

Tetrahedron letters, 1999-01, Vol.40 (4), p.661-664

1999

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A cell-free expression and purification process for rapid production of protein biologics

Pharmacokinetic properties of several novel oligonucleotide analogs in mice

2'-O-(2-Methoxy)ethyl-modified anti-intercellular adhesion molecule 1 (ICAM-1) oligonucleotides selectively increase the ICAM-1 mRNA level and inhibit formation of the ICAM-1 translation initiation complex in human umbilical vein endothelial cells

Antisense oligonucleotide inhibition of hepatitis C virus gene expression in transformed hepatocytes

Oligonucleotide-europium complex conjugate designed to cleave the 5' cap structure of the ICAM-1 transcript potentiates antisense activity in cells

Pharmacokinetic properties of 2'-O-(2-methoxyethyl)-modified oligonucleotide analogs in rats

Actin exposure upon tissue injury is a targetable wound site-specific protein marker

Pharmacokinetics of a tumor necrosis factor-alpha phosphorothioate 2'-O-(2-methoxyethyl) modified antisense oligonucleotide: comparison across species

A Perfectly Symmetric lac Operator Binds the lac Repressor Very Tightly

Characterization of a potent and specific class of antisense oligonucleotide inhibitor of human protein kinase C-alpha expression

Hydration of single-stranded phosphodiester and phosphorothioate oligodeoxyribonucleotides

Nuclease Resistance and Antisense Activity of Modified Oligonucleotides Targeted to Ha-ras

Measurement of Macromolecular Binding Using Electrospray Mass Spectrometry. Determination of Dissociation Constants for Oligonucleotide: Serum Albumin Complexes

Sequence-Specific Antitumor Activity of a Phosphorothioate Oligodeoxyribonucleotide Targeted to Human C-Raf Kinase Supports an Antisense Mechanism of Action in vivo

Influence of Diastereomeric Ratios of Deoxyribonucleoside Phosphoramidites on the Synthesis of Phosphorothioate Oligonucleotides

Specific binding of lac repressor to linear versus circular polyoperator molecules

Multiplexed Screening of Neutral Mass-Tagged RNA Targets against Ligand Libraries with Electrospray Ionization FTICR MS: A Paradigm for High-Throughput Affinity Screening

Absolute bioavailability of 2'-O-(2-methoxyethyl)-modified antisense oligonucleotides following intraduodenal instillation in rats

Targeted Site-Specific Gas-Phase Cleavage of Oligoribonucleotides. Application in Mass Spectrometry-Based Identification of Ligand Binding Sites

2‘-O-Aminopropyl Ribonucleotides: A Zwitterionic Modification That Enhances the Exonuclease Resistance and Biological Activity of Antisense Oligonucleotides

Oligodeoxynucleotides containing 2'-O-modified adenosine: Synthesis and effects on stability of DNA:RNA duplexes

Symmetric lac operator derivatives: effects of half-operator sequence and spacing on repressor affinity

Base substitution mutants of the lac operator: in vivo and in vitro affinities for lac repressor

Disposition of the 14C-labeled phosphorothioate oligonucleotide ISIS 2105 after intravenous administration to rats

Synthesis, hybridization, and nuclease resistance properties of 2′-O-aminooxyethyl ( 2′-O-AOE) modified oligonucleotides

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