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Systemic Elevation of PTEN Induces a Tumor-Suppressive Metabolic State

Cell, 2012-03, Vol.149 (1), p.49-62

2012

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GTP metabolic reprogramming by IMPDH2: unlocking cancer cells' fuelling mechanism

Journal of biochemistry (Tokyo), 2020-10, Vol.168 (4), p.319

2020

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Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species Contributes to Cellular Antioxidant Responses

Science (American Association for the Advancement of Science), 2011-12, Vol.334 (6060), p.1278-1283

2011

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Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer

The Journal of clinical investigation, 2008-09, Vol.118 (9), p.3065-3074

2008

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Dynamic compartmentalization of purine nucleotide metabolic enzymes at leading edge in highly motile renal cell carcinoma

Biochemical and biophysical research communications, 2019-08, Vol.516 (1), p.50-56

2019

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Anti-Tumor Potential of IMP Dehydrogenase Inhibitors: A Century-Long Story

Cancers, 2019-09, Vol.11 (9), p.1346

2019

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A Fluorescent Reporter of AMPK Activity and Cellular Energy Stress

Cell metabolism, 2011-04, Vol.13 (4), p.476-486

2011

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Inhibition of lung cancer growth: ATP citrate lyase knockdown and statin treatment leads to dual blockade of mitogen-activated protein Kinase (MAPK) and Phosphatidylinositol-3-kinase (PI3K)/AKT pathways

Journal of cellular physiology, 2012-04, Vol.227 (4), p.1709-1720

2012

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SI-MOIRAI: a new method to identify and quantify the metabolic fate of nucleotides

Journal of biochemistry (Tokyo), 2021-12, Vol.170 (6), p.699

2021

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The Lipid Kinase PI5P4Kβ Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis

Molecular cell, 2016-01, Vol.61 (2), p.187-198

2016

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Ubiquitination of K-Ras enhances activation and facilitates binding to select downstream effectors

Science signaling, 2011-03, Vol.4 (163), p.ra13

2011

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Identification of lysine methylation in the core GTPase domain by GoMADScan

PloS one, 2019-08, Vol.14 (8), p.e0219436-e0219436

2019

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Localized Ras Signaling at the Leading Edge Regulates PI3K, Cell Polarity, and Directional Cell Movement

The Journal of cell biology, 2004-11, Vol.167 (3), p.505-518

2004

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Depletion of a Putatively Druggable Class of Phosphatidylinositol Kinases Inhibits Growth of p53-Null Tumors

Cell, 2013-11, Vol.155 (4), p.844-857

2013

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Metabolic Compartmentalization at the Leading Edge of Metastatic Cancer Cells

Frontiers in oncology, 2020-11, Vol.10, p.554272-554272

2020

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Differences in the Regulation of K-Ras and H-Ras Isoforms by Monoubiquitination

The Journal of biological chemistry, 2013-12, Vol.288 (52), p.36856-36862

2013

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A Ras Signaling Complex Controls the RasC-TORC2 Pathway and Directed Cell Migration

Developmental cell, 2010-05, Vol.18 (5), p.737-749

2010

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Site-specific monoubiquitination activates Ras by impeding GTPase-activating protein function

Nature structural & molecular biology, 2013-01, Vol.20 (1), p.46

2013

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G protein-independent Ras/PI3K/F-actin circuit regulates basic cell motility

The Journal of cell biology, 2007-07, Vol.178 (2), p.185-191

2007

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Selenite targets eIF4E-binding protein-1 to inhibit translation initiation and induce the assembly of non-canonical stress granules

Nucleic acids research, 2012-09, Vol.40 (16), p.8099

2012

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Correction: Identification of lysine methylation in the core GTPase domain by GoMADScan

PloS one, 2019-10, Vol.14 (10), p.e0224443-e0224443

2019

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Use of Multiple Cryoprotectants to Improve Diffraction Quality from Protein Crystals

Crystal growth & design, 2016-03, Vol.16 (3), p.1565-1571

2016

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Regulation of chemotaxis by the orchestrated activation of Ras, PI3K, and TOR

European journal of cell biology, 2006-09, Vol.85 (9), p.873-895

2006

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Dynamic Role of the GTP Energy Metabolism in Cancers

The Keio Journal of Medicine, 2016, Vol.65(1), pp.21-21

Sasaki, Atsuo T.

2016

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Systemic Elevation of PTEN Induces a Tumor-Suppressive Metabolic State

GTP metabolic reprogramming by IMPDH2: unlocking cancer cells' fuelling mechanism

Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species Contributes to Cellular Antioxidant Responses

Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer

Dynamic compartmentalization of purine nucleotide metabolic enzymes at leading edge in highly motile renal cell carcinoma

Anti-Tumor Potential of IMP Dehydrogenase Inhibitors: A Century-Long Story

A Fluorescent Reporter of AMPK Activity and Cellular Energy Stress

Inhibition of lung cancer growth: ATP citrate lyase knockdown and statin treatment leads to dual blockade of mitogen-activated protein Kinase (MAPK) and Phosphatidylinositol-3-kinase (PI3K)/AKT pathways

SI-MOIRAI: a new method to identify and quantify the metabolic fate of nucleotides

The Lipid Kinase PI5P4Kβ Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis

Ubiquitination of K-Ras enhances activation and facilitates binding to select downstream effectors

Identification of lysine methylation in the core GTPase domain by GoMADScan

Localized Ras Signaling at the Leading Edge Regulates PI3K, Cell Polarity, and Directional Cell Movement

Depletion of a Putatively Druggable Class of Phosphatidylinositol Kinases Inhibits Growth of p53-Null Tumors

Metabolic Compartmentalization at the Leading Edge of Metastatic Cancer Cells

Differences in the Regulation of K-Ras and H-Ras Isoforms by Monoubiquitination

A Ras Signaling Complex Controls the RasC-TORC2 Pathway and Directed Cell Migration

Site-specific monoubiquitination activates Ras by impeding GTPase-activating protein function

G protein-independent Ras/PI3K/F-actin circuit regulates basic cell motility

Selenite targets eIF4E-binding protein-1 to inhibit translation initiation and induce the assembly of non-canonical stress granules

IMPDH inhibition activates TLR‐VCAM1 pathway and suppresses the development of MLL‐fusion leukemia

Correction: Identification of lysine methylation in the core GTPase domain by GoMADScan

Use of Multiple Cryoprotectants to Improve Diffraction Quality from Protein Crystals

Regulation of chemotaxis by the orchestrated activation of Ras, PI3K, and TOR

Dynamic Role of the GTP Energy Metabolism in Cancers

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